Potential target within the tumor microenvironment - MT1-MMP
Matrix metalloproteinases are integral to the modification of the tumor microenvironment and facilitate tumor progression by degrading the extracellular matrix, releasing cytokines, and influencing the recruitment of immune cells. Among the matrix metalloproteinases, membrane-type matrix metalloprot...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1517519/full |
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| author | Jinlong Liu Jinlong Liu Yijing Li Yijing Li Xueqi Lian Xueqi Lian Chenglin Zhang Chenglin Zhang Jianing Feng Jianing Feng Hongfei Tao Hongfei Tao Zhimin Wang |
| author_facet | Jinlong Liu Jinlong Liu Yijing Li Yijing Li Xueqi Lian Xueqi Lian Chenglin Zhang Chenglin Zhang Jianing Feng Jianing Feng Hongfei Tao Hongfei Tao Zhimin Wang |
| author_sort | Jinlong Liu |
| collection | DOAJ |
| description | Matrix metalloproteinases are integral to the modification of the tumor microenvironment and facilitate tumor progression by degrading the extracellular matrix, releasing cytokines, and influencing the recruitment of immune cells. Among the matrix metalloproteinases, membrane-type matrix metalloproteinase 1 (MT1-MMP/MMP14) is the first identified membrane-type MMP and acts as an essential proteolytic enzyme that enables tumor infiltration and metastatic progression. Given the pivotal role of MT1-MMP in tumor progression and the correlation between its overexpression in tumors and unfavorable prognoses across multiple cancer types, a comprehensive understanding of the potential functional mechanisms of MT1-MMP is essential. This knowledge will aid in the advancement of diverse anti-tumor therapies aimed at targeting MT1-MMP. Although contemporary research has highlighted the considerable potential of MT1-MMP in targeted cancer therapy, studies pertaining to its application in cell therapy remain relatively limited. In this review, we delineate the structural characteristics and regulatory mechanisms of MT1-MMP expression, as well as its biological significance in tumorigenesis. Finally, we discussed the current status and prospects of anti-tumor therapies targeting MT1-MMP. |
| format | Article |
| id | doaj-art-e13a6f490b484d94abbdd46e7ec908b7 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-e13a6f490b484d94abbdd46e7ec908b72025-08-20T03:40:03ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-03-011610.3389/fimmu.2025.15175191517519Potential target within the tumor microenvironment - MT1-MMPJinlong Liu0Jinlong Liu1Yijing Li2Yijing Li3Xueqi Lian4Xueqi Lian5Chenglin Zhang6Chenglin Zhang7Jianing Feng8Jianing Feng9Hongfei Tao10Hongfei Tao11Zhimin Wang12School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, ChinaCentre for Cell and Gene Therapy, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, ChinaSchool of Basic Medical Sciences, Zhengzhou University, Zhengzhou, ChinaCentre for Cell and Gene Therapy, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, ChinaSchool of Basic Medical Sciences, Zhengzhou University, Zhengzhou, ChinaCentre for Cell and Gene Therapy, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, ChinaSchool of Basic Medical Sciences, Zhengzhou University, Zhengzhou, ChinaCentre for Cell and Gene Therapy, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, ChinaSchool of Basic Medical Sciences, Zhengzhou University, Zhengzhou, ChinaCentre for Cell and Gene Therapy, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, ChinaSchool of Basic Medical Sciences, Zhengzhou University, Zhengzhou, ChinaCentre for Cell and Gene Therapy, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, ChinaSchool of Basic Medical Sciences, Zhengzhou University, Zhengzhou, ChinaMatrix metalloproteinases are integral to the modification of the tumor microenvironment and facilitate tumor progression by degrading the extracellular matrix, releasing cytokines, and influencing the recruitment of immune cells. Among the matrix metalloproteinases, membrane-type matrix metalloproteinase 1 (MT1-MMP/MMP14) is the first identified membrane-type MMP and acts as an essential proteolytic enzyme that enables tumor infiltration and metastatic progression. Given the pivotal role of MT1-MMP in tumor progression and the correlation between its overexpression in tumors and unfavorable prognoses across multiple cancer types, a comprehensive understanding of the potential functional mechanisms of MT1-MMP is essential. This knowledge will aid in the advancement of diverse anti-tumor therapies aimed at targeting MT1-MMP. Although contemporary research has highlighted the considerable potential of MT1-MMP in targeted cancer therapy, studies pertaining to its application in cell therapy remain relatively limited. In this review, we delineate the structural characteristics and regulatory mechanisms of MT1-MMP expression, as well as its biological significance in tumorigenesis. Finally, we discussed the current status and prospects of anti-tumor therapies targeting MT1-MMP.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1517519/fullMT1-MMP1tumor microenvironment2targeted therapy3extracellular matrix4metastasis5 |
| spellingShingle | Jinlong Liu Jinlong Liu Yijing Li Yijing Li Xueqi Lian Xueqi Lian Chenglin Zhang Chenglin Zhang Jianing Feng Jianing Feng Hongfei Tao Hongfei Tao Zhimin Wang Potential target within the tumor microenvironment - MT1-MMP Frontiers in Immunology MT1-MMP1 tumor microenvironment2 targeted therapy3 extracellular matrix4 metastasis5 |
| title | Potential target within the tumor microenvironment - MT1-MMP |
| title_full | Potential target within the tumor microenvironment - MT1-MMP |
| title_fullStr | Potential target within the tumor microenvironment - MT1-MMP |
| title_full_unstemmed | Potential target within the tumor microenvironment - MT1-MMP |
| title_short | Potential target within the tumor microenvironment - MT1-MMP |
| title_sort | potential target within the tumor microenvironment mt1 mmp |
| topic | MT1-MMP1 tumor microenvironment2 targeted therapy3 extracellular matrix4 metastasis5 |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1517519/full |
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