Information transmission in a cell monolayer: A numerical study.
Motivated by the spatiotemporal waves of MAPK/ERK activity, crucial for long-range communication in regenerating tissues, we investigated stochastic homoclinic fronts propagating through channels formed by directly interacting cells. We evaluated the efficiency of long-range communication in these c...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2025-02-01
|
| Series: | PLoS Computational Biology |
| Online Access: | https://doi.org/10.1371/journal.pcbi.1012846 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850277683904118784 |
|---|---|
| author | Paweł Nałęcz-Jawecki Przemysław Szyc Frederic Grabowski Marek Kochańczyk Tomasz Lipniacki |
| author_facet | Paweł Nałęcz-Jawecki Przemysław Szyc Frederic Grabowski Marek Kochańczyk Tomasz Lipniacki |
| author_sort | Paweł Nałęcz-Jawecki |
| collection | DOAJ |
| description | Motivated by the spatiotemporal waves of MAPK/ERK activity, crucial for long-range communication in regenerating tissues, we investigated stochastic homoclinic fronts propagating through channels formed by directly interacting cells. We evaluated the efficiency of long-range communication in these channels by examining the rate of information transmission. Our study identified the stochastic phenomena that reduce this rate: front propagation failure, new front spawning, and variability in the front velocity. We found that a trade-off between the frequencies of propagation failures and new front spawning determines the optimal channel width (which geometrically determines the front length). The optimal frequency of initiating new waves is determined by a trade-off between the input information rate (higher with more frequent initiation) and the fidelity of information transmission (lower with more frequent initiation). Our analysis provides insight into the relative timescales of intra- and intercellular processes necessary for successful wave propagation. |
| format | Article |
| id | doaj-art-e13831dcae9b4fc798870a820cd37f3c |
| institution | OA Journals |
| issn | 1553-734X 1553-7358 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Computational Biology |
| spelling | doaj-art-e13831dcae9b4fc798870a820cd37f3c2025-08-20T01:49:47ZengPublic Library of Science (PLoS)PLoS Computational Biology1553-734X1553-73582025-02-01212e101284610.1371/journal.pcbi.1012846Information transmission in a cell monolayer: A numerical study.Paweł Nałęcz-JaweckiPrzemysław SzycFrederic GrabowskiMarek KochańczykTomasz LipniackiMotivated by the spatiotemporal waves of MAPK/ERK activity, crucial for long-range communication in regenerating tissues, we investigated stochastic homoclinic fronts propagating through channels formed by directly interacting cells. We evaluated the efficiency of long-range communication in these channels by examining the rate of information transmission. Our study identified the stochastic phenomena that reduce this rate: front propagation failure, new front spawning, and variability in the front velocity. We found that a trade-off between the frequencies of propagation failures and new front spawning determines the optimal channel width (which geometrically determines the front length). The optimal frequency of initiating new waves is determined by a trade-off between the input information rate (higher with more frequent initiation) and the fidelity of information transmission (lower with more frequent initiation). Our analysis provides insight into the relative timescales of intra- and intercellular processes necessary for successful wave propagation.https://doi.org/10.1371/journal.pcbi.1012846 |
| spellingShingle | Paweł Nałęcz-Jawecki Przemysław Szyc Frederic Grabowski Marek Kochańczyk Tomasz Lipniacki Information transmission in a cell monolayer: A numerical study. PLoS Computational Biology |
| title | Information transmission in a cell monolayer: A numerical study. |
| title_full | Information transmission in a cell monolayer: A numerical study. |
| title_fullStr | Information transmission in a cell monolayer: A numerical study. |
| title_full_unstemmed | Information transmission in a cell monolayer: A numerical study. |
| title_short | Information transmission in a cell monolayer: A numerical study. |
| title_sort | information transmission in a cell monolayer a numerical study |
| url | https://doi.org/10.1371/journal.pcbi.1012846 |
| work_keys_str_mv | AT pawełnałeczjawecki informationtransmissioninacellmonolayeranumericalstudy AT przemysławszyc informationtransmissioninacellmonolayeranumericalstudy AT fredericgrabowski informationtransmissioninacellmonolayeranumericalstudy AT marekkochanczyk informationtransmissioninacellmonolayeranumericalstudy AT tomaszlipniacki informationtransmissioninacellmonolayeranumericalstudy |