First Evidence of Cotinine in Canine Semen Reveals Tobacco Smoke Exposure
Tobacco smoke has numerous adverse effects on both human and animal health, including impaired reproductive function. Recent research has explored environmental exposure in dogs, investigating various biological matrices. However, no data are currently available on the presence of cotinine, a nicoti...
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MDPI AG
2024-11-01
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| Series: | Veterinary Sciences |
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| Online Access: | https://www.mdpi.com/2306-7381/11/12/598 |
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| author | Debora Groppetti Giulia Pizzi Elisa Giussani Alessandro Pecile Silvia Michela Mazzola Valerio Bronzo Eleonora Fusi |
| author_facet | Debora Groppetti Giulia Pizzi Elisa Giussani Alessandro Pecile Silvia Michela Mazzola Valerio Bronzo Eleonora Fusi |
| author_sort | Debora Groppetti |
| collection | DOAJ |
| description | Tobacco smoke has numerous adverse effects on both human and animal health, including impaired reproductive function. Recent research has explored environmental exposure in dogs, investigating various biological matrices. However, no data are currently available on the presence of cotinine, a nicotine metabolite, in the canine ejaculate. This study aimed to evaluate the detectability of cotinine in the semen of dogs living with smoking owners. Additionally, seminal cotinine concentrations were correlated with those in serum and hair. To further examine the potential impact of smoking on canine fertility, the relationships between seminal cotinine, total sperm concentration, and antioxidant activity in plasma and semen were analyzed in exposed and non-exposed dogs. This study is the first to demonstrate the presence of cotinine in canine ejaculate and its correlation with blood and hair concentrations. While the potential toxic effect of cotinine on seminal parameters and male fertility in dogs requires further investigation, it is crucial to raise awareness among pet owners about the risks associated with domestic smoking for their animals. |
| format | Article |
| id | doaj-art-e137b877f5b644f3a6d2f9e9e0651e8c |
| institution | DOAJ |
| issn | 2306-7381 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Veterinary Sciences |
| spelling | doaj-art-e137b877f5b644f3a6d2f9e9e0651e8c2025-08-20T02:57:01ZengMDPI AGVeterinary Sciences2306-73812024-11-01111259810.3390/vetsci11120598First Evidence of Cotinine in Canine Semen Reveals Tobacco Smoke ExposureDebora Groppetti0Giulia Pizzi1Elisa Giussani2Alessandro Pecile3Silvia Michela Mazzola4Valerio Bronzo5Eleonora Fusi6Department of Veterinary Medicine and Animal Sciences, Università degli Studi di Milano, 26900 Lodi, ItalyPrivate Practitioner, Specialist in Animal Reproduction, 20841 Carate Brianza, MB, ItalyDepartment of Veterinary Medicine and Animal Sciences, Università degli Studi di Milano, 26900 Lodi, ItalyDepartment of Veterinary Medicine and Animal Sciences, Università degli Studi di Milano, 26900 Lodi, ItalyDepartment of Veterinary Medicine and Animal Sciences, Università degli Studi di Milano, 26900 Lodi, ItalyDepartment of Veterinary Medicine and Animal Sciences, Università degli Studi di Milano, 26900 Lodi, ItalyDepartment of Veterinary Medicine and Animal Sciences, Università degli Studi di Milano, 26900 Lodi, ItalyTobacco smoke has numerous adverse effects on both human and animal health, including impaired reproductive function. Recent research has explored environmental exposure in dogs, investigating various biological matrices. However, no data are currently available on the presence of cotinine, a nicotine metabolite, in the canine ejaculate. This study aimed to evaluate the detectability of cotinine in the semen of dogs living with smoking owners. Additionally, seminal cotinine concentrations were correlated with those in serum and hair. To further examine the potential impact of smoking on canine fertility, the relationships between seminal cotinine, total sperm concentration, and antioxidant activity in plasma and semen were analyzed in exposed and non-exposed dogs. This study is the first to demonstrate the presence of cotinine in canine ejaculate and its correlation with blood and hair concentrations. While the potential toxic effect of cotinine on seminal parameters and male fertility in dogs requires further investigation, it is crucial to raise awareness among pet owners about the risks associated with domestic smoking for their animals.https://www.mdpi.com/2306-7381/11/12/598cigarettedogoxidative stresssperm concentrationsmoking |
| spellingShingle | Debora Groppetti Giulia Pizzi Elisa Giussani Alessandro Pecile Silvia Michela Mazzola Valerio Bronzo Eleonora Fusi First Evidence of Cotinine in Canine Semen Reveals Tobacco Smoke Exposure Veterinary Sciences cigarette dog oxidative stress sperm concentration smoking |
| title | First Evidence of Cotinine in Canine Semen Reveals Tobacco Smoke Exposure |
| title_full | First Evidence of Cotinine in Canine Semen Reveals Tobacco Smoke Exposure |
| title_fullStr | First Evidence of Cotinine in Canine Semen Reveals Tobacco Smoke Exposure |
| title_full_unstemmed | First Evidence of Cotinine in Canine Semen Reveals Tobacco Smoke Exposure |
| title_short | First Evidence of Cotinine in Canine Semen Reveals Tobacco Smoke Exposure |
| title_sort | first evidence of cotinine in canine semen reveals tobacco smoke exposure |
| topic | cigarette dog oxidative stress sperm concentration smoking |
| url | https://www.mdpi.com/2306-7381/11/12/598 |
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