Statin-associated muscle disorders
Statins are one of the most widely used and reputable medications worldwide, with strong evidence of mitigating cardiovascular complications and with a generally favorable safety profile. Nevertheless, statins have commonly come under scrutiny, owing to their associations with muscle disorders. Stat...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2020-01-01
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| Series: | Indian Journal of Rheumatology |
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| Online Access: | http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2020;volume=15;issue=6;spage=137;epage=144;aulast=Xu |
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| _version_ | 1850283239361478656 |
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| author | Alan Xu Vidya Limaye |
| author_facet | Alan Xu Vidya Limaye |
| author_sort | Alan Xu |
| collection | DOAJ |
| description | Statins are one of the most widely used and reputable medications worldwide, with strong evidence of mitigating cardiovascular complications and with a generally favorable safety profile. Nevertheless, statins have commonly come under scrutiny, owing to their associations with muscle disorders. Statins are known to cause a range of effects on muscles, varying from mild self-limiting symptoms to detrimental muscular necrosis. In particular, there has been emerging evidence of statin-associated necrotizing autoimmune myositis related to the presence of anti-3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) autoantibodies. Patients often demonstrate proximal muscle weakness and hyperCKemia, and treatment guidelines are not robust owing to the rarity of the disease. Nevertheless, literature provides evidence for use of corticosteroids, and there are emerging data supporting the incorporation of immunomodulatory agents such as methotrexate, intravenous immunoglobulin, and rituximab. In performing this review, we searched databases in PubMed and EMBASE written in English and limited to the last two decades. Keywords used included “statin,” “myositis,” “autoimmune myopathy,” “anti-HMGCR,” and “necrotising.” Articles were selected by relevance to the topic, and articles pertaining to antisignal recognition particle myopathy and other forms of myositis were excluded. |
| format | Article |
| id | doaj-art-e137991620004ddba8a36a976bdc4ee1 |
| institution | OA Journals |
| issn | 0973-3698 0973-3701 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Indian Journal of Rheumatology |
| spelling | doaj-art-e137991620004ddba8a36a976bdc4ee12025-08-20T01:47:49ZengSAGE PublishingIndian Journal of Rheumatology0973-36980973-37012020-01-0115613714410.4103/injr.injr_81_20Statin-associated muscle disordersAlan XuVidya LimayeStatins are one of the most widely used and reputable medications worldwide, with strong evidence of mitigating cardiovascular complications and with a generally favorable safety profile. Nevertheless, statins have commonly come under scrutiny, owing to their associations with muscle disorders. Statins are known to cause a range of effects on muscles, varying from mild self-limiting symptoms to detrimental muscular necrosis. In particular, there has been emerging evidence of statin-associated necrotizing autoimmune myositis related to the presence of anti-3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) autoantibodies. Patients often demonstrate proximal muscle weakness and hyperCKemia, and treatment guidelines are not robust owing to the rarity of the disease. Nevertheless, literature provides evidence for use of corticosteroids, and there are emerging data supporting the incorporation of immunomodulatory agents such as methotrexate, intravenous immunoglobulin, and rituximab. In performing this review, we searched databases in PubMed and EMBASE written in English and limited to the last two decades. Keywords used included “statin,” “myositis,” “autoimmune myopathy,” “anti-HMGCR,” and “necrotising.” Articles were selected by relevance to the topic, and articles pertaining to antisignal recognition particle myopathy and other forms of myositis were excluded.http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2020;volume=15;issue=6;spage=137;epage=144;aulast=Xuanti-3-hydroxy-3-methylglutaryl coenzyme a reductasemyopathystatins |
| spellingShingle | Alan Xu Vidya Limaye Statin-associated muscle disorders Indian Journal of Rheumatology anti-3-hydroxy-3-methylglutaryl coenzyme a reductase myopathy statins |
| title | Statin-associated muscle disorders |
| title_full | Statin-associated muscle disorders |
| title_fullStr | Statin-associated muscle disorders |
| title_full_unstemmed | Statin-associated muscle disorders |
| title_short | Statin-associated muscle disorders |
| title_sort | statin associated muscle disorders |
| topic | anti-3-hydroxy-3-methylglutaryl coenzyme a reductase myopathy statins |
| url | http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2020;volume=15;issue=6;spage=137;epage=144;aulast=Xu |
| work_keys_str_mv | AT alanxu statinassociatedmuscledisorders AT vidyalimaye statinassociatedmuscledisorders |