Identification and Validation of Th1-Selective Epitopes Derived from Proteins Overexpressed in Breast Cancer Stem Cells

Identification and Validation of Th1-Selective Epitopes Derived from Proteins Overexpressed in Breast Cancer Stem Cells

Background: Breast cancer stem cells (CSCs), particularly those enriched in triple-negative breast cancer (TNBC), are key contributors to tumor recurrence, metastasis, and resistance to therapy. CSCs often undergo epithelial-to-mesenchymal transformation (EMT), enhancing their invasiveness. Immune-b...

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Bibliographic Details
Main Authors: Denise L. Cecil, Daniel Herendeen, Meredith Slota, Megan M. O’Meara, Yushe Dang, Lauren Corulli, Mary L. Disis
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Vaccines
Subjects:
T-helper 1
vaccine
epitopes
cancer stem cells
epithelial-to-mesenchymal transformation
Online Access:https://www.mdpi.com/2076-393X/13/5/525
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