Study of Natural Cytotoxicity Receptors in Patients with HIV/AIDS and Cancer: A Cross-Sectional Study
The NCR receptors play a fundamental role in the cytotoxicity mediated by NK cells against tumor cells. In the current study, we investigated possible HIV/AIDS-related changes in the expression of the NCR receptors comparing healthy donors, HIV/AIDS patients, and HIV/AIDS patients with cancer (HIV/A...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2016/2085871 |
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| author | Orlando Nascimento Terra Junior Gabriel de Carvalho Maldonado Guilherme Rohem Alfradique Vinicius da Cunha Lisboa Adriano Arnóbio Dirce Bonfim de Lima Hilda Rachel Diamond Maria Helena Faria Ornellas de Souza |
| author_facet | Orlando Nascimento Terra Junior Gabriel de Carvalho Maldonado Guilherme Rohem Alfradique Vinicius da Cunha Lisboa Adriano Arnóbio Dirce Bonfim de Lima Hilda Rachel Diamond Maria Helena Faria Ornellas de Souza |
| author_sort | Orlando Nascimento Terra Junior |
| collection | DOAJ |
| description | The NCR receptors play a fundamental role in the cytotoxicity mediated by NK cells against tumor cells. In the current study, we investigated possible HIV/AIDS-related changes in the expression of the NCR receptors comparing healthy donors, HIV/AIDS patients, and HIV/AIDS patients with cancer (HIV/AIDSWC). The NCRs were quantified in NK cells (NKdim and NKbright) and T lymphocytes from peripheral blood samples by flow cytometry. We found a significant decrease in the frequency of NK cells expressing NKp46 in HIV/AIDS group (p=0.0012). There was a decrease in the frequency of NK cells expressing NKp46 in the HIV/AIDSWC group; however, this was not statistically significant. We found a significant decrease in the frequency of NK cells expressing NKp30 in the HIV/AIDS group (p=0.0144). There was a decrease in the frequency of NK cells expressing NKp30 and in the HIV/AIDSWC group, but this was not statistically significant. There were no changes in the distribution of NK cells and their subtypes in both groups. |
| format | Article |
| id | doaj-art-e13670b236424d7ca3810c29097d3878 |
| institution | OA Journals |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-e13670b236424d7ca3810c29097d38782025-08-20T02:21:17ZengWileyThe Scientific World Journal2356-61401537-744X2016-01-01201610.1155/2016/20858712085871Study of Natural Cytotoxicity Receptors in Patients with HIV/AIDS and Cancer: A Cross-Sectional StudyOrlando Nascimento Terra Junior0Gabriel de Carvalho Maldonado1Guilherme Rohem Alfradique2Vinicius da Cunha Lisboa3Adriano Arnóbio4Dirce Bonfim de Lima5Hilda Rachel Diamond6Maria Helena Faria Ornellas de Souza7School of Medical Sciences, Rio de Janeiro State University, Professor Manoel de Abreu Avenue 444, 20550-170 Rio de Janeiro, RJ, BrazilSchool of Medical Sciences, Rio de Janeiro State University, Professor Manoel de Abreu Avenue 444, 20550-170 Rio de Janeiro, RJ, BrazilSchool of Medical Sciences, Rio de Janeiro State University, Professor Manoel de Abreu Avenue 444, 20550-170 Rio de Janeiro, RJ, BrazilSchool of Medical Sciences, Rio de Janeiro State University, Professor Manoel de Abreu Avenue 444, 20550-170 Rio de Janeiro, RJ, BrazilSchool of Medical Sciences, Rio de Janeiro State University, Professor Manoel de Abreu Avenue 444, 20550-170 Rio de Janeiro, RJ, BrazilSchool of Medical Sciences, Rio de Janeiro State University, Professor Manoel de Abreu Avenue 444, 20550-170 Rio de Janeiro, RJ, BrazilSchool of Medical Sciences, Rio de Janeiro State University, Professor Manoel de Abreu Avenue 444, 20550-170 Rio de Janeiro, RJ, BrazilSchool of Medical Sciences, Rio de Janeiro State University, Professor Manoel de Abreu Avenue 444, 20550-170 Rio de Janeiro, RJ, BrazilThe NCR receptors play a fundamental role in the cytotoxicity mediated by NK cells against tumor cells. In the current study, we investigated possible HIV/AIDS-related changes in the expression of the NCR receptors comparing healthy donors, HIV/AIDS patients, and HIV/AIDS patients with cancer (HIV/AIDSWC). The NCRs were quantified in NK cells (NKdim and NKbright) and T lymphocytes from peripheral blood samples by flow cytometry. We found a significant decrease in the frequency of NK cells expressing NKp46 in HIV/AIDS group (p=0.0012). There was a decrease in the frequency of NK cells expressing NKp46 in the HIV/AIDSWC group; however, this was not statistically significant. We found a significant decrease in the frequency of NK cells expressing NKp30 in the HIV/AIDS group (p=0.0144). There was a decrease in the frequency of NK cells expressing NKp30 and in the HIV/AIDSWC group, but this was not statistically significant. There were no changes in the distribution of NK cells and their subtypes in both groups.http://dx.doi.org/10.1155/2016/2085871 |
| spellingShingle | Orlando Nascimento Terra Junior Gabriel de Carvalho Maldonado Guilherme Rohem Alfradique Vinicius da Cunha Lisboa Adriano Arnóbio Dirce Bonfim de Lima Hilda Rachel Diamond Maria Helena Faria Ornellas de Souza Study of Natural Cytotoxicity Receptors in Patients with HIV/AIDS and Cancer: A Cross-Sectional Study The Scientific World Journal |
| title | Study of Natural Cytotoxicity Receptors in Patients with HIV/AIDS and Cancer: A Cross-Sectional Study |
| title_full | Study of Natural Cytotoxicity Receptors in Patients with HIV/AIDS and Cancer: A Cross-Sectional Study |
| title_fullStr | Study of Natural Cytotoxicity Receptors in Patients with HIV/AIDS and Cancer: A Cross-Sectional Study |
| title_full_unstemmed | Study of Natural Cytotoxicity Receptors in Patients with HIV/AIDS and Cancer: A Cross-Sectional Study |
| title_short | Study of Natural Cytotoxicity Receptors in Patients with HIV/AIDS and Cancer: A Cross-Sectional Study |
| title_sort | study of natural cytotoxicity receptors in patients with hiv aids and cancer a cross sectional study |
| url | http://dx.doi.org/10.1155/2016/2085871 |
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