Pediatric brucellosis in the central mediterranean region of Türkiye: Insights from a single-center experience
Objective: We aimed to contribute to the literature by presenting the epidemiologic, clinical, and laboratory characteristics of pediatric patients with brucellosis followed up by our clinic. Method: The medical records of patients aged 0-18 years who were followed up with a diagnosis of brucello...
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| Format: | Article |
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Aydın Pediatric Society
2023-06-01
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| Series: | Trends in Pediatrics |
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| Online Access: | https://trendspediatrics.com/article/view/92 |
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| author | Elif Güdeloğlu Hasan Tezer Meltem Polat Nursel Kara Ulu Nursel Atay Ünal Volkan Medeni Sezin Helvacıoğlu Ayyıldız Emine Yılmaz Orulluoğlu Tuğba Bedir Demirdağ Anıl Tapısız |
| author_facet | Elif Güdeloğlu Hasan Tezer Meltem Polat Nursel Kara Ulu Nursel Atay Ünal Volkan Medeni Sezin Helvacıoğlu Ayyıldız Emine Yılmaz Orulluoğlu Tuğba Bedir Demirdağ Anıl Tapısız |
| author_sort | Elif Güdeloğlu |
| collection | DOAJ |
| description |
Objective: We aimed to contribute to the literature by presenting the epidemiologic, clinical, and laboratory characteristics of pediatric patients with brucellosis followed up by our clinic.
Method: The medical records of patients aged 0-18 years who were followed up with a diagnosis of brucellosis in Gazi University Pediatric Infectious Diseases Clinic between 2010-2020 were retrospectively analyzed. The effect of demographic, clinical, and laboratory markers on diagnosis was investigated.
Results: The mean age was 162.0 ± 55.5 months. Of the 47 patients included in our study, 68% lived in rural areas. While 82.5% had a background of consuming raw milk and dairy products, 55% had experience in animal husbandry. Twenty-two patients had a family history of brucellosis. The most common symptoms were joint pain in 85%, malaise in 78%, and muscle pain in 42%. The most common associated findings were fever in 59%, joint stiffness in 23%, and splenomegaly in 17%. The decrease in erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) values and the increases in leukocytes, hemoglobin, and platelets before and after treatment were statistically significant (p<0.001). Anemia was the most common in the patients, followed by neutropenia, thrombocytopenia, thrombocytosis, leukocytosis, and pancytopenia, respectively. Blood culture positivity was 12%. Of 47 patients with positive tube agglutination titer, Rose Bengal was positive in 80% and negative in 19%.
Conclusion: Brucellosis remains an important public health problem in Türkiye. Patients should be questioned in detail in the presence of fever, arthralgia, hepatosplenomegaly, and pancytopenia which presents with different clinical findings. Rose Bengal negativity, which is used as a screening test, should not mislead us in making a diagnosis in the presence of clinical suspicion. Tube agglutination tests should definitely be performed in patients with suspected brucellosis. In addition, changes in non-specific blood parameters such as CRP, ESR, leukocytes, hemoglobin, and platelets may be indicative for clinicians.
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| format | Article |
| id | doaj-art-e13467af12014aca871d03a453315021 |
| institution | OA Journals |
| issn | 2792-0429 |
| language | English |
| publishDate | 2023-06-01 |
| publisher | Aydın Pediatric Society |
| record_format | Article |
| series | Trends in Pediatrics |
| spelling | doaj-art-e13467af12014aca871d03a4533150212025-08-20T02:03:27ZengAydın Pediatric SocietyTrends in Pediatrics2792-04292023-06-014210.59213/TP.2023.27928Pediatric brucellosis in the central mediterranean region of Türkiye: Insights from a single-center experienceElif Güdeloğlu0https://orcid.org/0000-0002-3818-017XHasan Tezer1https://orcid.org/0000-0001-6871-4112Meltem Polat2https://orcid.org/0000-0002-4608-1286Nursel Kara Ulu3https://orcid.org/0000-0001-6219-5454Nursel Atay Ünal4https://orcid.org/0000-0002-0118-1961Volkan Medeni5https://orcid.org/0000-0002-2544-5781Sezin Helvacıoğlu Ayyıldız6https://orcid.org/0009-0006-4146-3206Emine Yılmaz Orulluoğlu7https://orcid.org/0009-0009-7073-5962Tuğba Bedir Demirdağ8https://orcid.org/0000-0002-6341-1849Anıl Tapısız9https://orcid.org/0000-0002-6897-8297Gazi University, Faculty of Medicine, Department of Pediatric Infectious Diseases, Ankara, TürkiyeGazi University, Faculty of Medicine, Department of Pediatric Infectious Diseases, Ankara, TürkiyeGazi University, Faculty of Medicine, Department of Pediatric Infectious Diseases, Ankara, TürkiyeGazi University, Faculty of Medicine, Department of Pediatric Infectious Diseases, Ankara, TürkiyeGazi University, Faculty of Medicine, Department of Pediatric Infectious Diseases, Ankara, TürkiyeGazi University, Faculty of Medicine, Department of Public Health, Ankara, TürkiyeGazi University, Faculty of Medicine, Department of Pediatrics, Ankara, TürkiyeGazi University, Faculty of Medicine, Department of Pediatrics, Ankara, TürkiyeGazi University, Faculty of Medicine, Department of Pediatric Infectious Diseases, Ankara, TürkiyeGazi University, Faculty of Medicine, Department of Pediatric Infectious Diseases, Ankara, Türkiye Objective: We aimed to contribute to the literature by presenting the epidemiologic, clinical, and laboratory characteristics of pediatric patients with brucellosis followed up by our clinic. Method: The medical records of patients aged 0-18 years who were followed up with a diagnosis of brucellosis in Gazi University Pediatric Infectious Diseases Clinic between 2010-2020 were retrospectively analyzed. The effect of demographic, clinical, and laboratory markers on diagnosis was investigated. Results: The mean age was 162.0 ± 55.5 months. Of the 47 patients included in our study, 68% lived in rural areas. While 82.5% had a background of consuming raw milk and dairy products, 55% had experience in animal husbandry. Twenty-two patients had a family history of brucellosis. The most common symptoms were joint pain in 85%, malaise in 78%, and muscle pain in 42%. The most common associated findings were fever in 59%, joint stiffness in 23%, and splenomegaly in 17%. The decrease in erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) values and the increases in leukocytes, hemoglobin, and platelets before and after treatment were statistically significant (p<0.001). Anemia was the most common in the patients, followed by neutropenia, thrombocytopenia, thrombocytosis, leukocytosis, and pancytopenia, respectively. Blood culture positivity was 12%. Of 47 patients with positive tube agglutination titer, Rose Bengal was positive in 80% and negative in 19%. Conclusion: Brucellosis remains an important public health problem in Türkiye. Patients should be questioned in detail in the presence of fever, arthralgia, hepatosplenomegaly, and pancytopenia which presents with different clinical findings. Rose Bengal negativity, which is used as a screening test, should not mislead us in making a diagnosis in the presence of clinical suspicion. Tube agglutination tests should definitely be performed in patients with suspected brucellosis. In addition, changes in non-specific blood parameters such as CRP, ESR, leukocytes, hemoglobin, and platelets may be indicative for clinicians. https://trendspediatrics.com/article/view/92Bloodbrucellosischildhood |
| spellingShingle | Elif Güdeloğlu Hasan Tezer Meltem Polat Nursel Kara Ulu Nursel Atay Ünal Volkan Medeni Sezin Helvacıoğlu Ayyıldız Emine Yılmaz Orulluoğlu Tuğba Bedir Demirdağ Anıl Tapısız Pediatric brucellosis in the central mediterranean region of Türkiye: Insights from a single-center experience Trends in Pediatrics Blood brucellosis childhood |
| title | Pediatric brucellosis in the central mediterranean region of Türkiye: Insights from a single-center experience |
| title_full | Pediatric brucellosis in the central mediterranean region of Türkiye: Insights from a single-center experience |
| title_fullStr | Pediatric brucellosis in the central mediterranean region of Türkiye: Insights from a single-center experience |
| title_full_unstemmed | Pediatric brucellosis in the central mediterranean region of Türkiye: Insights from a single-center experience |
| title_short | Pediatric brucellosis in the central mediterranean region of Türkiye: Insights from a single-center experience |
| title_sort | pediatric brucellosis in the central mediterranean region of turkiye insights from a single center experience |
| topic | Blood brucellosis childhood |
| url | https://trendspediatrics.com/article/view/92 |
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