Sympathetic Prions
Transmissible spongiform encephalopathies are a group of invariably fatal neurodegenerative diseases. The infectious agent is termed prion and is thought to be composed of a modified protein (PrPSc or PrPRES), a protease-resistant conformer of the normal host-encoded membrane glycoprotein, PrPC[1]....
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| Format: | Article |
| Language: | English |
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Wiley
2001-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2001.258 |
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| author | Markus Glatzel |
| author_facet | Markus Glatzel |
| author_sort | Markus Glatzel |
| collection | DOAJ |
| description | Transmissible spongiform encephalopathies are a group of invariably fatal neurodegenerative diseases. The infectious agent is termed prion and is thought to be composed of a modified protein (PrPSc or PrPRES), a protease-resistant conformer of the normal host-encoded membrane glycoprotein, PrPC[1]. Bovine spongiform encephalopathy, scrapie of sheep, and Creutzfeldt-Jakob disease are among the most notable transmissible spongiform encephalopathies. Prions are most efficiently propagated trough intracerebral inoculation, yet the entry point of the infectious agent is often through peripheral sites like the gastrointestinal tract[2,3]. The process by which prions invade the brain is termed neuroinvasion[4]. We and others have speculated that, depending on the amount of infectious agent injected, the injection site, and the strain of prions employed, neuroinvasion can occur either directly via peripheral nerves or first through the lymphoreticular system and then via peripheral nerves[5]. |
| format | Article |
| id | doaj-art-e13337406d3b4fe3ae5dc7bdb972a643 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2001-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-e13337406d3b4fe3ae5dc7bdb972a6432025-02-03T06:00:09ZengWileyThe Scientific World Journal1537-744X2001-01-01155555610.1100/tsw.2001.258Sympathetic PrionsMarkus Glatzel0Institute of Neuropathology, University Hospital Zürich, SwitzerlandTransmissible spongiform encephalopathies are a group of invariably fatal neurodegenerative diseases. The infectious agent is termed prion and is thought to be composed of a modified protein (PrPSc or PrPRES), a protease-resistant conformer of the normal host-encoded membrane glycoprotein, PrPC[1]. Bovine spongiform encephalopathy, scrapie of sheep, and Creutzfeldt-Jakob disease are among the most notable transmissible spongiform encephalopathies. Prions are most efficiently propagated trough intracerebral inoculation, yet the entry point of the infectious agent is often through peripheral sites like the gastrointestinal tract[2,3]. The process by which prions invade the brain is termed neuroinvasion[4]. We and others have speculated that, depending on the amount of infectious agent injected, the injection site, and the strain of prions employed, neuroinvasion can occur either directly via peripheral nerves or first through the lymphoreticular system and then via peripheral nerves[5].http://dx.doi.org/10.1100/tsw.2001.258 |
| spellingShingle | Markus Glatzel Sympathetic Prions The Scientific World Journal |
| title | Sympathetic Prions |
| title_full | Sympathetic Prions |
| title_fullStr | Sympathetic Prions |
| title_full_unstemmed | Sympathetic Prions |
| title_short | Sympathetic Prions |
| title_sort | sympathetic prions |
| url | http://dx.doi.org/10.1100/tsw.2001.258 |
| work_keys_str_mv | AT markusglatzel sympatheticprions |