Mean Arteriolar Diameter Measured from Wide-Field Swept-Source OCT Angiography: A Highly Sensitive Indicator for Mean Arterial Pressure
Purpose: To investigate the metrics of retinal arterioles and venules based on the en face images of the superficial retina using wide-field swept-source OCT angiography (SSOCTA) and assess their relationships with specific systemic parameters in a normal sample. Design: Cross-sectional study. Parti...
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Elsevier
2025-05-01
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| Series: | Ophthalmology Science |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S266691452400215X |
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| author | Yuchen Li Yuyao Qu Hanze Zhang Yue Bian Langxuan Yuan Jingbo Hu Shengrui Xu Xiayu Xu, PhD Jianqin Lei, MD |
| author_facet | Yuchen Li Yuyao Qu Hanze Zhang Yue Bian Langxuan Yuan Jingbo Hu Shengrui Xu Xiayu Xu, PhD Jianqin Lei, MD |
| author_sort | Yuchen Li |
| collection | DOAJ |
| description | Purpose: To investigate the metrics of retinal arterioles and venules based on the en face images of the superficial retina using wide-field swept-source OCT angiography (SSOCTA) and assess their relationships with specific systemic parameters in a normal sample. Design: Cross-sectional study. Participants: Normal volunteers with no history of hypertension, diabetes, or significant eye diseases were recruited at the outpatient clinic of the First Affiliated Hospital of Xi’an Jiaotong University. Eligible eyes had a corrected visual acuity of 20/25 or better and an intraocular pressure (IOP) not exceeding 21 mmHg. Methods: The SSOCTA scans of 24 × 20 mm in size were acquired from both eyes of each participant, along with measurements of axial length (AL), IOP, real-time mean arterial pressure (MAP), and body mass index (BMI). Retinal arterioles and venules were manually segmented and distinguished from the disc margin to their capillary junctions in the superficial retinal layer. Image processing and calculations were performed using ImageJ. Main Outcome Measurements: The averaged caliber and fractal dimension of arteries and veins, as well as the arteriovenous ratio, were calculated from binarized vascular images. Generalized linear mixed models were used to test correlations between systemic parameters and these metrics. Results: A total of 54 eyes from 44 participants were included after screening. Univariate analysis revealed a significant negative impact of MAP on averaged caliber of retinal artery (B = −0.003, P = 0.004) and averaged caliber of retinal vein (ACvein) (B = −0.002, P = 0.045), whereas age, sex, BMI, AL, and IOP showed no significant impact on these metrics. Variations among graders significantly influenced most metrics; however, real-time MAP continued to predict retinal arteriolar caliber after adjusting for graders (B = −0.002, P = 0.03). Conclusions: The mean arteriolar diameter measured using wide-field SSOCTA could serve as a highly sensitive indicator of systemic vascular changes. Financial Disclosure(s): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article. |
| format | Article |
| id | doaj-art-e12fbf09ac144015a57b1701465124c3 |
| institution | DOAJ |
| issn | 2666-9145 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
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| series | Ophthalmology Science |
| spelling | doaj-art-e12fbf09ac144015a57b1701465124c32025-08-20T02:47:09ZengElsevierOphthalmology Science2666-91452025-05-015310067910.1016/j.xops.2024.100679Mean Arteriolar Diameter Measured from Wide-Field Swept-Source OCT Angiography: A Highly Sensitive Indicator for Mean Arterial PressureYuchen Li0Yuyao Qu1Hanze Zhang2Yue Bian3Langxuan Yuan4Jingbo Hu5Shengrui Xu6Xiayu Xu, PhD7Jianqin Lei, MD8Department of Ophthalmology, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, PR ChinaDepartment of Ophthalmology, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, PR ChinaDepartment of Ophthalmology, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, PR ChinaDepartment of Ophthalmology, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, PR ChinaDepartment of Ophthalmology, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, PR ChinaDepartment of Ophthalmology, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, PR ChinaThe Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, PR China; Bioinspired Engineering and Biomechanics Center (BEBC), Xi’an Jiaotong University, Xi’an, PR ChinaThe Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, PR China; Bioinspired Engineering and Biomechanics Center (BEBC), Xi’an Jiaotong University, Xi’an, PR China; Xiayu Xu, PhD, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi’an Jiaotong University, 28# West Xian Ning Road, Xi'an 710049, Shaanxi, PR China.Department of Ophthalmology, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, PR China; Correspondence: Jianqin Lei, MD, Department of Ophthalmology, First Affiliated Hospital of Xi’an Jiaotong University, 277# West Yan Ta Road, Xi’an 710061, Shaanxi, PR China.Purpose: To investigate the metrics of retinal arterioles and venules based on the en face images of the superficial retina using wide-field swept-source OCT angiography (SSOCTA) and assess their relationships with specific systemic parameters in a normal sample. Design: Cross-sectional study. Participants: Normal volunteers with no history of hypertension, diabetes, or significant eye diseases were recruited at the outpatient clinic of the First Affiliated Hospital of Xi’an Jiaotong University. Eligible eyes had a corrected visual acuity of 20/25 or better and an intraocular pressure (IOP) not exceeding 21 mmHg. Methods: The SSOCTA scans of 24 × 20 mm in size were acquired from both eyes of each participant, along with measurements of axial length (AL), IOP, real-time mean arterial pressure (MAP), and body mass index (BMI). Retinal arterioles and venules were manually segmented and distinguished from the disc margin to their capillary junctions in the superficial retinal layer. Image processing and calculations were performed using ImageJ. Main Outcome Measurements: The averaged caliber and fractal dimension of arteries and veins, as well as the arteriovenous ratio, were calculated from binarized vascular images. Generalized linear mixed models were used to test correlations between systemic parameters and these metrics. Results: A total of 54 eyes from 44 participants were included after screening. Univariate analysis revealed a significant negative impact of MAP on averaged caliber of retinal artery (B = −0.003, P = 0.004) and averaged caliber of retinal vein (ACvein) (B = −0.002, P = 0.045), whereas age, sex, BMI, AL, and IOP showed no significant impact on these metrics. Variations among graders significantly influenced most metrics; however, real-time MAP continued to predict retinal arteriolar caliber after adjusting for graders (B = −0.002, P = 0.03). Conclusions: The mean arteriolar diameter measured using wide-field SSOCTA could serve as a highly sensitive indicator of systemic vascular changes. Financial Disclosure(s): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.http://www.sciencedirect.com/science/article/pii/S266691452400215XMean arterial pressureRetinal arteriolesRetinal venulesSegmentationWide-field swept-source OCT angiography |
| spellingShingle | Yuchen Li Yuyao Qu Hanze Zhang Yue Bian Langxuan Yuan Jingbo Hu Shengrui Xu Xiayu Xu, PhD Jianqin Lei, MD Mean Arteriolar Diameter Measured from Wide-Field Swept-Source OCT Angiography: A Highly Sensitive Indicator for Mean Arterial Pressure Ophthalmology Science Mean arterial pressure Retinal arterioles Retinal venules Segmentation Wide-field swept-source OCT angiography |
| title | Mean Arteriolar Diameter Measured from Wide-Field Swept-Source OCT Angiography: A Highly Sensitive Indicator for Mean Arterial Pressure |
| title_full | Mean Arteriolar Diameter Measured from Wide-Field Swept-Source OCT Angiography: A Highly Sensitive Indicator for Mean Arterial Pressure |
| title_fullStr | Mean Arteriolar Diameter Measured from Wide-Field Swept-Source OCT Angiography: A Highly Sensitive Indicator for Mean Arterial Pressure |
| title_full_unstemmed | Mean Arteriolar Diameter Measured from Wide-Field Swept-Source OCT Angiography: A Highly Sensitive Indicator for Mean Arterial Pressure |
| title_short | Mean Arteriolar Diameter Measured from Wide-Field Swept-Source OCT Angiography: A Highly Sensitive Indicator for Mean Arterial Pressure |
| title_sort | mean arteriolar diameter measured from wide field swept source oct angiography a highly sensitive indicator for mean arterial pressure |
| topic | Mean arterial pressure Retinal arterioles Retinal venules Segmentation Wide-field swept-source OCT angiography |
| url | http://www.sciencedirect.com/science/article/pii/S266691452400215X |
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