Perturbing local steroidogenesis to improve breast cancer immunity

Perturbing local steroidogenesis to improve breast cancer immunity

Abstract Breast cancer, particularly triple-negative breast cancer (TNBC), evades the body’s immune defences, in part by cultivating an immunosuppressive tumour microenvironment. Here, we show that suppressing local steroidogenesis can augment anti-tumour immunity against TNBC. Through targeted meta...

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Bibliographic Details
Main Authors: Qiuchen Zhao, Jhuma Pramanik, Yongjin Lu, Natalie Z. M. Homer, Charlotte J. Imianowski, Baojie Zhang, Muhammad Iqbal, Sanu Korumadathil Shaji, Andrew Conway Morris, Rahul Roychoudhuri, Klaus Okkenhaug, Pengfei Qiu, Bidesh Mahata
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59356-3
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