Refractory Paraneoplastic Diarrhea Secondary to Adenocarcinoma of the Lung: A Case Report and Literature Review

Paraneoplastic diarrhea is a commonly described complication of gastrointestinal tract or endocrine malignancies. It is an extremely rare complication of lung adenocarcinoma, with only one previously reported case in the literature. A 46-year-old female with newly diagnosed stage IVb lung adenocarci...

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Main Authors: Lauren Howdershelt, Michael J. Forte, Rahul G. Sangani
Format: Article
Language:English
Published: Wiley 2020-01-01
Series:Case Reports in Critical Care
Online Access:http://dx.doi.org/10.1155/2020/8825845
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author Lauren Howdershelt
Michael J. Forte
Rahul G. Sangani
author_facet Lauren Howdershelt
Michael J. Forte
Rahul G. Sangani
author_sort Lauren Howdershelt
collection DOAJ
description Paraneoplastic diarrhea is a commonly described complication of gastrointestinal tract or endocrine malignancies. It is an extremely rare complication of lung adenocarcinoma, with only one previously reported case in the literature. A 46-year-old female with newly diagnosed stage IVb lung adenocarcinoma presented to our intensive care unit in hypovolemic shock with symptoms suggestive of diabetes insipidus (DI) as well as profuse large volume watery diarrhea. Exhaustive serological and microbiological workup revealed the diarrhea to be paraneoplasitc in nature. This case represents the second known case of paraneoplastic diarrhea secondary to lung adenocarcinoma. Clinicians should be aware of this rare phenomenon.
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issn 2090-6420
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spelling doaj-art-e12a937304aa470e878164333d9ac5bc2025-08-20T03:26:00ZengWileyCase Reports in Critical Care2090-64202090-64392020-01-01202010.1155/2020/88258458825845Refractory Paraneoplastic Diarrhea Secondary to Adenocarcinoma of the Lung: A Case Report and Literature ReviewLauren Howdershelt0Michael J. Forte1Rahul G. Sangani2Department of Family Medicine, West Virginia University, 1 Medical Center Dr., Morgantown WV 26506, USADepartment of Medicine, Section of Pulmonary, Critical Care and Sleep Medicine, West Virginia University, 1 Medical Center Dr., Morgantown WV 26506, USADepartment of Medicine, Section of Pulmonary, Critical Care and Sleep Medicine, West Virginia University, 1 Medical Center Dr., Morgantown WV 26506, USAParaneoplastic diarrhea is a commonly described complication of gastrointestinal tract or endocrine malignancies. It is an extremely rare complication of lung adenocarcinoma, with only one previously reported case in the literature. A 46-year-old female with newly diagnosed stage IVb lung adenocarcinoma presented to our intensive care unit in hypovolemic shock with symptoms suggestive of diabetes insipidus (DI) as well as profuse large volume watery diarrhea. Exhaustive serological and microbiological workup revealed the diarrhea to be paraneoplasitc in nature. This case represents the second known case of paraneoplastic diarrhea secondary to lung adenocarcinoma. Clinicians should be aware of this rare phenomenon.http://dx.doi.org/10.1155/2020/8825845
spellingShingle Lauren Howdershelt
Michael J. Forte
Rahul G. Sangani
Refractory Paraneoplastic Diarrhea Secondary to Adenocarcinoma of the Lung: A Case Report and Literature Review
Case Reports in Critical Care
title Refractory Paraneoplastic Diarrhea Secondary to Adenocarcinoma of the Lung: A Case Report and Literature Review
title_full Refractory Paraneoplastic Diarrhea Secondary to Adenocarcinoma of the Lung: A Case Report and Literature Review
title_fullStr Refractory Paraneoplastic Diarrhea Secondary to Adenocarcinoma of the Lung: A Case Report and Literature Review
title_full_unstemmed Refractory Paraneoplastic Diarrhea Secondary to Adenocarcinoma of the Lung: A Case Report and Literature Review
title_short Refractory Paraneoplastic Diarrhea Secondary to Adenocarcinoma of the Lung: A Case Report and Literature Review
title_sort refractory paraneoplastic diarrhea secondary to adenocarcinoma of the lung a case report and literature review
url http://dx.doi.org/10.1155/2020/8825845
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AT rahulgsangani refractoryparaneoplasticdiarrheasecondarytoadenocarcinomaofthelungacasereportandliteraturereview