Strengths and weaknesses of transcranial ultrasound stimulation and its promise in psychiatry: an overview of the technology and a systematic review of the clinical applications
This article reviews early studies that have demonstrated the ability of low intensity ultrasound waves to modulate brain activity. It also reviews the technological developments that have enabled transcranial ultrasound stimulation (TUS) to achieve millimetric spatial accuracy. This allows precise,...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | International Journal of Hyperthermia |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/02656736.2025.2539986 |
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| author | David Attali Maxime Daniel Marion Plaze Jean-François Aubry |
| author_facet | David Attali Maxime Daniel Marion Plaze Jean-François Aubry |
| author_sort | David Attali |
| collection | DOAJ |
| description | This article reviews early studies that have demonstrated the ability of low intensity ultrasound waves to modulate brain activity. It also reviews the technological developments that have enabled transcranial ultrasound stimulation (TUS) to achieve millimetric spatial accuracy. This allows precise, noninvasive and reversible brain stimulation, a unique capability when compared to existing techniques such as transcranial magnetic stimulation, transcranial direct-current stimulation, and deep brain stimulation with implanted electrodes. TUS is now technologically ready for clinical translation. As psychiatric disorders have a high prevalence in the general population, and suffer from unmet noninvasive deep brain stimulation clinical needs, this article focuses on the potential application of TUS in psychiatry and reviews recently published clinical proofs of concept that have addressed depression, anxiety, schizophrenia and substance use disorders. Finally, the strengths and weaknesses of TUS technology are discussed, with reference to its clinical translation. |
| format | Article |
| id | doaj-art-e129052d3c4f4670933d9c04a7023213 |
| institution | Kabale University |
| issn | 0265-6736 1464-5157 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | International Journal of Hyperthermia |
| spelling | doaj-art-e129052d3c4f4670933d9c04a70232132025-08-20T03:59:32ZengTaylor & Francis GroupInternational Journal of Hyperthermia0265-67361464-51572025-12-0142110.1080/02656736.2025.2539986Strengths and weaknesses of transcranial ultrasound stimulation and its promise in psychiatry: an overview of the technology and a systematic review of the clinical applicationsDavid Attali0Maxime Daniel1Marion Plaze2Jean-François Aubry3Institute Physics for Medicine Paris, Inserm U1273, ESPCI Paris, PSL University, CNRS UMR 8063, Paris, FranceInstitute Physics for Medicine Paris, Inserm U1273, ESPCI Paris, PSL University, CNRS UMR 8063, Paris, FranceGHU Paris Psychiatrie & Neurosciences, Hôpital Sainte-Anne, Paris, FranceInstitute Physics for Medicine Paris, Inserm U1273, ESPCI Paris, PSL University, CNRS UMR 8063, Paris, FranceThis article reviews early studies that have demonstrated the ability of low intensity ultrasound waves to modulate brain activity. It also reviews the technological developments that have enabled transcranial ultrasound stimulation (TUS) to achieve millimetric spatial accuracy. This allows precise, noninvasive and reversible brain stimulation, a unique capability when compared to existing techniques such as transcranial magnetic stimulation, transcranial direct-current stimulation, and deep brain stimulation with implanted electrodes. TUS is now technologically ready for clinical translation. As psychiatric disorders have a high prevalence in the general population, and suffer from unmet noninvasive deep brain stimulation clinical needs, this article focuses on the potential application of TUS in psychiatry and reviews recently published clinical proofs of concept that have addressed depression, anxiety, schizophrenia and substance use disorders. Finally, the strengths and weaknesses of TUS technology are discussed, with reference to its clinical translation.https://www.tandfonline.com/doi/10.1080/02656736.2025.2539986Neuromodulationtranscranial ultrasound stimulationnumerical modelingpsychiatrydepressionaddiction |
| spellingShingle | David Attali Maxime Daniel Marion Plaze Jean-François Aubry Strengths and weaknesses of transcranial ultrasound stimulation and its promise in psychiatry: an overview of the technology and a systematic review of the clinical applications International Journal of Hyperthermia Neuromodulation transcranial ultrasound stimulation numerical modeling psychiatry depression addiction |
| title | Strengths and weaknesses of transcranial ultrasound stimulation and its promise in psychiatry: an overview of the technology and a systematic review of the clinical applications |
| title_full | Strengths and weaknesses of transcranial ultrasound stimulation and its promise in psychiatry: an overview of the technology and a systematic review of the clinical applications |
| title_fullStr | Strengths and weaknesses of transcranial ultrasound stimulation and its promise in psychiatry: an overview of the technology and a systematic review of the clinical applications |
| title_full_unstemmed | Strengths and weaknesses of transcranial ultrasound stimulation and its promise in psychiatry: an overview of the technology and a systematic review of the clinical applications |
| title_short | Strengths and weaknesses of transcranial ultrasound stimulation and its promise in psychiatry: an overview of the technology and a systematic review of the clinical applications |
| title_sort | strengths and weaknesses of transcranial ultrasound stimulation and its promise in psychiatry an overview of the technology and a systematic review of the clinical applications |
| topic | Neuromodulation transcranial ultrasound stimulation numerical modeling psychiatry depression addiction |
| url | https://www.tandfonline.com/doi/10.1080/02656736.2025.2539986 |
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