Advance in identified targets of berberine
Berberine is an isoquinoline alkaloid, which has demonstrated significant therapeutic potential in the treatment of various diseases, including tumors, acute and chronic infections, autoimmune disorders, and diabetes. Studies have demonstrated that berberine exhibits polypharmacological effects, inc...
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| Format: | Article |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1500511/full |
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| author | Penghai Sun Ziyuan Wang Yinchao Ma Yuan Liu Yintong Xue Yan Li Xiang Gao Yuedan Wang Ming Chu Ming Chu Ming Chu Ming Chu |
| author_facet | Penghai Sun Ziyuan Wang Yinchao Ma Yuan Liu Yintong Xue Yan Li Xiang Gao Yuedan Wang Ming Chu Ming Chu Ming Chu Ming Chu |
| author_sort | Penghai Sun |
| collection | DOAJ |
| description | Berberine is an isoquinoline alkaloid, which has demonstrated significant therapeutic potential in the treatment of various diseases, including tumors, acute and chronic infections, autoimmune disorders, and diabetes. Studies have demonstrated that berberine exhibits polypharmacological effects, including antibacterial, anti-inflammatory, antioxidant, and hypoglycemic activities. To further elucidate the multifaceted pharmacological mechanisms of berberine, we reviewed 7 targets of berberine identified through co-crystal structure analysis, including filamentous temperature-sensitive protein Z (FtsZ), QacR, BmrR, phospholipase A2 (PLA2), RamR, NIMA-related kinase 7 (NEK7), and mesenchymal-epithelial transition (MET). Through target fishing, molecular docking, and surface plasmon resonance (SPR) analyses, combined with cellular and molecular experiments, we further identified 6 targets of berberine. These findings provide a comprehensive summary of berberine’s direct molecular targets, offering a theoretical foundation for further exploration of its diverse pharmacological activities. |
| format | Article |
| id | doaj-art-e127428adfe842c8bbd8a38de2e6a064 |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-e127428adfe842c8bbd8a38de2e6a0642025-01-29T06:45:55ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-01-011610.3389/fphar.2025.15005111500511Advance in identified targets of berberinePenghai Sun0Ziyuan Wang1Yinchao Ma2Yuan Liu3Yintong Xue4Yan Li5Xiang Gao6Yuedan Wang7Ming Chu8Ming Chu9Ming Chu10Ming Chu11Department of Immunology, School of Basic Medical Sciences, Peking University, NHC Key Laboratory of Medical Immunology (Peking University), Beijing, ChinaDepartment of Immunology, School of Basic Medical Sciences, Peking University, NHC Key Laboratory of Medical Immunology (Peking University), Beijing, ChinaDepartment of Immunology, School of Basic Medical Sciences, Peking University, NHC Key Laboratory of Medical Immunology (Peking University), Beijing, ChinaDepartment of Immunology, School of Basic Medical Sciences, Peking University, NHC Key Laboratory of Medical Immunology (Peking University), Beijing, ChinaDepartment of Immunology, School of Basic Medical Sciences, Peking University, NHC Key Laboratory of Medical Immunology (Peking University), Beijing, ChinaDepartment of Immunology, School of Basic Medical Sciences, Peking University, NHC Key Laboratory of Medical Immunology (Peking University), Beijing, ChinaDepartment of Immunology, School of Basic Medical Sciences, Peking University, NHC Key Laboratory of Medical Immunology (Peking University), Beijing, ChinaDepartment of Immunology, School of Basic Medical Sciences, Peking University, NHC Key Laboratory of Medical Immunology (Peking University), Beijing, ChinaDepartment of Immunology, School of Basic Medical Sciences, Peking University, NHC Key Laboratory of Medical Immunology (Peking University), Beijing, ChinaBeijing Life Science Academy, Beijing, ChinaDepartment of Gastroenterology, Peking University Third Hospital, Beijing, ChinaBeijing Key Laboratory for Helicobacter Pylori Infection and Upper Gastrointestinal Diseases, Peking University Third Hospital, Beijing, ChinaBerberine is an isoquinoline alkaloid, which has demonstrated significant therapeutic potential in the treatment of various diseases, including tumors, acute and chronic infections, autoimmune disorders, and diabetes. Studies have demonstrated that berberine exhibits polypharmacological effects, including antibacterial, anti-inflammatory, antioxidant, and hypoglycemic activities. To further elucidate the multifaceted pharmacological mechanisms of berberine, we reviewed 7 targets of berberine identified through co-crystal structure analysis, including filamentous temperature-sensitive protein Z (FtsZ), QacR, BmrR, phospholipase A2 (PLA2), RamR, NIMA-related kinase 7 (NEK7), and mesenchymal-epithelial transition (MET). Through target fishing, molecular docking, and surface plasmon resonance (SPR) analyses, combined with cellular and molecular experiments, we further identified 6 targets of berberine. These findings provide a comprehensive summary of berberine’s direct molecular targets, offering a theoretical foundation for further exploration of its diverse pharmacological activities.https://www.frontiersin.org/articles/10.3389/fphar.2025.1500511/fullberberineftsZQacRBmrRPLA2ramR |
| spellingShingle | Penghai Sun Ziyuan Wang Yinchao Ma Yuan Liu Yintong Xue Yan Li Xiang Gao Yuedan Wang Ming Chu Ming Chu Ming Chu Ming Chu Advance in identified targets of berberine Frontiers in Pharmacology berberine ftsZ QacR BmrR PLA2 ramR |
| title | Advance in identified targets of berberine |
| title_full | Advance in identified targets of berberine |
| title_fullStr | Advance in identified targets of berberine |
| title_full_unstemmed | Advance in identified targets of berberine |
| title_short | Advance in identified targets of berberine |
| title_sort | advance in identified targets of berberine |
| topic | berberine ftsZ QacR BmrR PLA2 ramR |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1500511/full |
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