Effect of hazelnut oil on hematological parameters and liver histopathological changes induced by naproxen in local male mice
This study designed to identify the outcome use of naproxen on hematological parameters and liver histopathological changes and the effect of hazelnut oil on these parameters in local male mice. Eighteen mice were divided equally into three groups: and each group involved of 6 mice. The first group...
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Faculty of Veterinary Medicine, University of Kufa
2024-12-01
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| Series: | Kufa Journal for Veterinary Medical Sciences |
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| Online Access: | https://journal.uokufa.edu.iq/index.php/kjvs/article/view/16997 |
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| author | Mohammed Abed Mahmood |
| author_facet | Mohammed Abed Mahmood |
| author_sort | Mohammed Abed Mahmood |
| collection | DOAJ |
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This study designed to identify the outcome use of naproxen on hematological parameters and liver histopathological changes and the effect of hazelnut oil on these parameters in local male mice. Eighteen mice were divided equally into three groups: and each group involved of 6 mice. The first group is control group which received distal normal saline while the second group was treated with naproxen at 20 mg/kg of mice body weight. The third was group treated with hazelnut oil 3g/kg of mice body weight, after two hours followed by naproxen 20 mg/kg of mice body weight. The experimental study continues for 21 days. The hematological results exhibited a significant decrease in WBC, RBC, hemoglobin and hematocrit at P <0.05 in the second group treated with naproxen compared to the control group. The third group treated with hazelnut oil followed by naproxen showed a significant increase in hemoglobin and hematocrits at P <0.05 compared to the second group but the hematological values in the third group did not show a significant difference compared to the control group. The histopathological results showed normal liver histology in first group the end of the experimental study. The second group which was received the naproxen showed congestion of blood vessels, hemorrhage inflammatory cells infiltration, necrosis and the presence of Kupffer cells. The third group showed a histological appearance of the liver relatively similar to the control group. The hazelnut oil improved the hematological parameters in this study and preserved the histological structures of the liver from being affected by naproxen.
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| format | Article |
| id | doaj-art-e122aa28a1004104beb45a222b2bf936 |
| institution | DOAJ |
| issn | 2077-9798 2959-8478 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Faculty of Veterinary Medicine, University of Kufa |
| record_format | Article |
| series | Kufa Journal for Veterinary Medical Sciences |
| spelling | doaj-art-e122aa28a1004104beb45a222b2bf9362025-08-20T03:17:40ZengFaculty of Veterinary Medicine, University of KufaKufa Journal for Veterinary Medical Sciences2077-97982959-84782024-12-0115210.36326/kjvs/2024/v15i216997Effect of hazelnut oil on hematological parameters and liver histopathological changes induced by naproxen in local male miceMohammed Abed Mahmood0Department of Pathology, Faculty of Veterinary Medicine, University of Diyala; Diyala, Iraq. This study designed to identify the outcome use of naproxen on hematological parameters and liver histopathological changes and the effect of hazelnut oil on these parameters in local male mice. Eighteen mice were divided equally into three groups: and each group involved of 6 mice. The first group is control group which received distal normal saline while the second group was treated with naproxen at 20 mg/kg of mice body weight. The third was group treated with hazelnut oil 3g/kg of mice body weight, after two hours followed by naproxen 20 mg/kg of mice body weight. The experimental study continues for 21 days. The hematological results exhibited a significant decrease in WBC, RBC, hemoglobin and hematocrit at P <0.05 in the second group treated with naproxen compared to the control group. The third group treated with hazelnut oil followed by naproxen showed a significant increase in hemoglobin and hematocrits at P <0.05 compared to the second group but the hematological values in the third group did not show a significant difference compared to the control group. The histopathological results showed normal liver histology in first group the end of the experimental study. The second group which was received the naproxen showed congestion of blood vessels, hemorrhage inflammatory cells infiltration, necrosis and the presence of Kupffer cells. The third group showed a histological appearance of the liver relatively similar to the control group. The hazelnut oil improved the hematological parameters in this study and preserved the histological structures of the liver from being affected by naproxen. https://journal.uokufa.edu.iq/index.php/kjvs/article/view/16997Naproxenhazelnut oilhematological parametershistopathological changesliver |
| spellingShingle | Mohammed Abed Mahmood Effect of hazelnut oil on hematological parameters and liver histopathological changes induced by naproxen in local male mice Kufa Journal for Veterinary Medical Sciences Naproxen hazelnut oil hematological parameters histopathological changes liver |
| title | Effect of hazelnut oil on hematological parameters and liver histopathological changes induced by naproxen in local male mice |
| title_full | Effect of hazelnut oil on hematological parameters and liver histopathological changes induced by naproxen in local male mice |
| title_fullStr | Effect of hazelnut oil on hematological parameters and liver histopathological changes induced by naproxen in local male mice |
| title_full_unstemmed | Effect of hazelnut oil on hematological parameters and liver histopathological changes induced by naproxen in local male mice |
| title_short | Effect of hazelnut oil on hematological parameters and liver histopathological changes induced by naproxen in local male mice |
| title_sort | effect of hazelnut oil on hematological parameters and liver histopathological changes induced by naproxen in local male mice |
| topic | Naproxen hazelnut oil hematological parameters histopathological changes liver |
| url | https://journal.uokufa.edu.iq/index.php/kjvs/article/view/16997 |
| work_keys_str_mv | AT mohammedabedmahmood effectofhazelnutoilonhematologicalparametersandliverhistopathologicalchangesinducedbynaproxeninlocalmalemice |