Curative effect of different blood purification methods for uremic pruritus and their effects on the patients’ life quality
Objective To explore the curative effect of different blood purification methods in the treatment of uremic pruritus and their effects on the patients’ life quality.Methods The clinical data of 120 patients with uremic pruritus treated in our hospital between January 2013 and December2014 were revie...
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| Main Authors: | , |
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| Format: | Article |
| Language: | zho |
| Published: |
Editorial Department of Journal of Clinical Nephrology
2016-01-01
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| Series: | Linchuang shenzangbing zazhi |
| Subjects: | |
| Online Access: | http://www.lcszb.com/thesisDetails?columnId=57919040&Fpath=home&index=0 |
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| Summary: | Objective To explore the curative effect of different blood purification methods in the treatment of uremic pruritus and their effects on the patients’ life quality.Methods The clinical data of 120 patients with uremic pruritus treated in our hospital between January 2013 and December2014 were reviewed,and the patients were divided into two groups（n = 60） according to the different ways of blood purification:control group given hemodialysis（HD） for treatment;study group given hemodialysis plus hemoperfusion plus hemodialysis filtration（HD+ HP+ HDF）.The symptoms improvement,biochemical indexes and the scores of life quality in the two groups were compared.Results The effective rate of symptoms improvement on sleeping,appetite,high blood pressure and cutaneous pruritus were respectively 78.79%,80.00%,60.98%and 95.00%respectively in the study group,all significantly higher than those in the control group（58.06%,63.64%,48.89%and80.00%respectively）（P<0.05）.After treatment,the biochemical indexes were significantly improved in both groups,and the levels of serum creatinine（SCr）,urea nitrogen（BUN）,serum phosphorus（Pi）,serum parathyroid hormone（PTH） and serum β<sub>2</sub>-microglobulin（β<sub>2</sub>-MG） were respeclively（234.7 ± 58.9） μmol/L,（10.3 ± 3.1） mmol/L,（1.1 ± 0.8） mmol/L,（98.5 ± 59.1） pmol/L and（15.4 ± 6.5） mg/L in the study group,all significantly higher than those in the control group[（461.5 ± 184.7） μmol/L,（18.1 ± 7.3） mmol/L,（2.8 ± 1.0） mmol/L,（275.8 ± 138.7） pmol/L,and（28.0±7.1）（mg/L）,with statistically significant differences both within each group and between the groups（P<0.05,P<0.01）.In addition,after treatment,the life quality of the patients was improved in both the two groups,with QOL,WHOQOL and SF-36 respectively（63.8 ± 5.3）,（64.7 ± 4.7） and（65.1 ± 5.4） in the study group,higher than those in the control group[（59.8 ±6.1）,（58.7 ± 4.1） and（59.1±4.2） respectively]（P<0.05,P<0.01）.Conclusions HD+HP +HDF is with significant curative effect for the treatment of uremic pruritus,which can effectively improve the biochemical index and life quality of the patients,thus worthwhile to be popularized into clinical application. |
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| ISSN: | 1671-2390 |