Cancer Immunotherapy: Priming the Host Immune Response with Live Attenuated Salmonella enterica
In recent years, cancer immunotherapy has undergone great advances because of our understanding of the immune response and the mechanisms through which tumor cells evade it. A century after the first immunotherapy attempt based on bacterial products described by William Coley, the use of live attenu...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2018/2984247 |
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| _version_ | 1850166425388318720 |
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| author | Marco Antonio Hernández-Luna Rosendo Luria-Pérez |
| author_facet | Marco Antonio Hernández-Luna Rosendo Luria-Pérez |
| author_sort | Marco Antonio Hernández-Luna |
| collection | DOAJ |
| description | In recent years, cancer immunotherapy has undergone great advances because of our understanding of the immune response and the mechanisms through which tumor cells evade it. A century after the first immunotherapy attempt based on bacterial products described by William Coley, the use of live attenuated bacterial vectors has become a promising alternative in the fight against cancer. This review describes the role of live attenuated Salmonella enterica as an oncolytic and immunotherapeutic agent, due to its high affinity for tumor tissue and its ability to activate innate and adaptive antitumor immune response. Furthermore, its potential use as delivery system of tumor antigens and immunomodulatory molecules that induce tumor regression is also reviewed. |
| format | Article |
| id | doaj-art-e11f16495ce34ea99d2f4dd9403065b9 |
| institution | OA Journals |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-e11f16495ce34ea99d2f4dd9403065b92025-08-20T02:21:28ZengWileyJournal of Immunology Research2314-88612314-71562018-01-01201810.1155/2018/29842472984247Cancer Immunotherapy: Priming the Host Immune Response with Live Attenuated Salmonella entericaMarco Antonio Hernández-Luna0Rosendo Luria-Pérez1Department of Medicine and Nutrition, University of Guanajuato, Campus Leon, Leon, GTO, MexicoUnit of Investigative Research on Oncological Diseases, Children's Hospital of Mexico Federico Gomez, Mexico City, MexicoIn recent years, cancer immunotherapy has undergone great advances because of our understanding of the immune response and the mechanisms through which tumor cells evade it. A century after the first immunotherapy attempt based on bacterial products described by William Coley, the use of live attenuated bacterial vectors has become a promising alternative in the fight against cancer. This review describes the role of live attenuated Salmonella enterica as an oncolytic and immunotherapeutic agent, due to its high affinity for tumor tissue and its ability to activate innate and adaptive antitumor immune response. Furthermore, its potential use as delivery system of tumor antigens and immunomodulatory molecules that induce tumor regression is also reviewed.http://dx.doi.org/10.1155/2018/2984247 |
| spellingShingle | Marco Antonio Hernández-Luna Rosendo Luria-Pérez Cancer Immunotherapy: Priming the Host Immune Response with Live Attenuated Salmonella enterica Journal of Immunology Research |
| title | Cancer Immunotherapy: Priming the Host Immune Response with Live Attenuated Salmonella enterica |
| title_full | Cancer Immunotherapy: Priming the Host Immune Response with Live Attenuated Salmonella enterica |
| title_fullStr | Cancer Immunotherapy: Priming the Host Immune Response with Live Attenuated Salmonella enterica |
| title_full_unstemmed | Cancer Immunotherapy: Priming the Host Immune Response with Live Attenuated Salmonella enterica |
| title_short | Cancer Immunotherapy: Priming the Host Immune Response with Live Attenuated Salmonella enterica |
| title_sort | cancer immunotherapy priming the host immune response with live attenuated salmonella enterica |
| url | http://dx.doi.org/10.1155/2018/2984247 |
| work_keys_str_mv | AT marcoantoniohernandezluna cancerimmunotherapyprimingthehostimmuneresponsewithliveattenuatedsalmonellaenterica AT rosendoluriaperez cancerimmunotherapyprimingthehostimmuneresponsewithliveattenuatedsalmonellaenterica |