Tipping the Proteome with Gene-Based Vaccines: Weighing in on the Role of Nanomaterials
Since the first generation of DNA vaccines was introduced in 1988, remarkable improvements have been made to improve their efficacy and immunogenicity. Although human clinical trials have shown that delivery of DNA vaccines is well tolerated and safe, the potency of these vaccines in humans is somew...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Nanotechnology |
| Online Access: | http://dx.doi.org/10.1155/2012/843170 |
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| author | Kristin J. Flores Michael Craig Adam Wanekaya Lifeng Dong Kartik Ghosh Joshua J. Smith Robert K. DeLong |
| author_facet | Kristin J. Flores Michael Craig Adam Wanekaya Lifeng Dong Kartik Ghosh Joshua J. Smith Robert K. DeLong |
| author_sort | Kristin J. Flores |
| collection | DOAJ |
| description | Since the first generation of DNA vaccines was introduced in 1988, remarkable improvements have been made to improve their efficacy and immunogenicity. Although human clinical trials have shown that delivery of DNA vaccines is well tolerated and safe, the potency of these vaccines in humans is somewhat less than optimal. The development of a gene-based vaccine that was effective enough to be approved for clinical use in humans would be one of, if not the most important, advance in vaccines to date. This paper highlights the literature relating to gene-based vaccines, specifically DNA vaccines, and suggests possible approaches to boost their performance. In addition, we explore the idea that combining RNA and nanomaterials may hold the key to successful gene-based vaccines for prevention and treatment of disease. |
| format | Article |
| id | doaj-art-e11876f6c7c7489f90f686c701c78003 |
| institution | Kabale University |
| issn | 1687-9503 1687-9511 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Nanotechnology |
| spelling | doaj-art-e11876f6c7c7489f90f686c701c780032025-08-20T03:26:00ZengWileyJournal of Nanotechnology1687-95031687-95112012-01-01201210.1155/2012/843170843170Tipping the Proteome with Gene-Based Vaccines: Weighing in on the Role of NanomaterialsKristin J. Flores0Michael Craig1Adam Wanekaya2Lifeng Dong3Kartik Ghosh4Joshua J. Smith5Robert K. DeLong6Department Biomedical Sciences, Missouri State University, Cell and Molecular Biology Program, Professional Building, Springfield, MO 65897, USADepartment Biomedical Sciences, Missouri State University, Cell and Molecular Biology Program, Professional Building, Springfield, MO 65897, USADepartment Chemistry, Missouri State University, Temple Hall, Springfield, MO 65897, USADepartment Physics, Astronomy & Materials Science, Missouri State University, Kemper Hall, Springfield, MO 65897, USADepartment Physics, Astronomy & Materials Science, Missouri State University, Kemper Hall, Springfield, MO 65897, USADepartment Biomedical Sciences, Missouri State University, Cell and Molecular Biology Program, Professional Building, Springfield, MO 65897, USADepartment Biomedical Sciences, Missouri State University, Cell and Molecular Biology Program, Professional Building, Springfield, MO 65897, USASince the first generation of DNA vaccines was introduced in 1988, remarkable improvements have been made to improve their efficacy and immunogenicity. Although human clinical trials have shown that delivery of DNA vaccines is well tolerated and safe, the potency of these vaccines in humans is somewhat less than optimal. The development of a gene-based vaccine that was effective enough to be approved for clinical use in humans would be one of, if not the most important, advance in vaccines to date. This paper highlights the literature relating to gene-based vaccines, specifically DNA vaccines, and suggests possible approaches to boost their performance. In addition, we explore the idea that combining RNA and nanomaterials may hold the key to successful gene-based vaccines for prevention and treatment of disease.http://dx.doi.org/10.1155/2012/843170 |
| spellingShingle | Kristin J. Flores Michael Craig Adam Wanekaya Lifeng Dong Kartik Ghosh Joshua J. Smith Robert K. DeLong Tipping the Proteome with Gene-Based Vaccines: Weighing in on the Role of Nanomaterials Journal of Nanotechnology |
| title | Tipping the Proteome with Gene-Based Vaccines: Weighing in on the Role of Nanomaterials |
| title_full | Tipping the Proteome with Gene-Based Vaccines: Weighing in on the Role of Nanomaterials |
| title_fullStr | Tipping the Proteome with Gene-Based Vaccines: Weighing in on the Role of Nanomaterials |
| title_full_unstemmed | Tipping the Proteome with Gene-Based Vaccines: Weighing in on the Role of Nanomaterials |
| title_short | Tipping the Proteome with Gene-Based Vaccines: Weighing in on the Role of Nanomaterials |
| title_sort | tipping the proteome with gene based vaccines weighing in on the role of nanomaterials |
| url | http://dx.doi.org/10.1155/2012/843170 |
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