Wnt/β-catenin signaling pathway role in the endometriosis pathogenesis
Endometriosis is a chronic estrogen-dependent disease characterized by the ectopic growth of endometrium-like tissue outside the uterus. In recent years, increasing attention has been paid to the role of the Wnt/β-catenin signaling pathway in endometriosis pathogenesis, wherein it regulates cell pro...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
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IRBIS LLC
2020-04-01
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| Series: | Акушерство, гинекология и репродукция |
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| Online Access: | https://www.gynecology.su/jour/article/view/2509 |
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| author | E. V. Virivskaya I. V. Ignatko I. A. Snimshchikova K. R. Bakhtiyarov A. S. Zueva T. D. Kapyrina |
| author_facet | E. V. Virivskaya I. V. Ignatko I. A. Snimshchikova K. R. Bakhtiyarov A. S. Zueva T. D. Kapyrina |
| author_sort | E. V. Virivskaya |
| collection | DOAJ |
| description | Endometriosis is a chronic estrogen-dependent disease characterized by the ectopic growth of endometrium-like tissue outside the uterus. In recent years, increasing attention has been paid to the role of the Wnt/β-catenin signaling pathway in endometriosis pathogenesis, wherein it regulates cell proliferation, migration, invasion, and fibrosis. Hyperactivation of the Wnt/β-catenin cascade promotes disease progression, chronic inflammation, and adhesion formation. MicroRNAs modulating this signaling pathway are of particular interest, offering potential for endometriosis diagnostics and targeted therapy. Further research may lead to new treatment approaches and improved quality of patients’ life. |
| format | Article |
| id | doaj-art-e115e1ad7e6b456b815b26faa37a73f4 |
| institution | Kabale University |
| issn | 2313-7347 2500-3194 |
| language | Russian |
| publishDate | 2020-04-01 |
| publisher | IRBIS LLC |
| record_format | Article |
| series | Акушерство, гинекология и репродукция |
| spelling | doaj-art-e115e1ad7e6b456b815b26faa37a73f42025-08-20T03:57:39ZrusIRBIS LLCАкушерство, гинекология и репродукция2313-73472500-31942020-04-010010.17749/2313-7347/ob.gyn.rep.2025.640993Wnt/β-catenin signaling pathway role in the endometriosis pathogenesisE. V. Virivskaya0I. V. Ignatko1I. A. Snimshchikova2K. R. Bakhtiyarov3A. S. Zueva4T. D. Kapyrina5Turgenev Orеl State University; Klinika Semeynaya LLCSechenov UniversityTurgenev Orеl State UniversitySechenov UniversitySechenov UniversitySechenov UniversityEndometriosis is a chronic estrogen-dependent disease characterized by the ectopic growth of endometrium-like tissue outside the uterus. In recent years, increasing attention has been paid to the role of the Wnt/β-catenin signaling pathway in endometriosis pathogenesis, wherein it regulates cell proliferation, migration, invasion, and fibrosis. Hyperactivation of the Wnt/β-catenin cascade promotes disease progression, chronic inflammation, and adhesion formation. MicroRNAs modulating this signaling pathway are of particular interest, offering potential for endometriosis diagnostics and targeted therapy. Further research may lead to new treatment approaches and improved quality of patients’ life.https://www.gynecology.su/jour/article/view/2509endometriosiswnt/β-catenin signaling pathwaycell proliferationfibrosismicrornasadhesion formationtargeted therapy |
| spellingShingle | E. V. Virivskaya I. V. Ignatko I. A. Snimshchikova K. R. Bakhtiyarov A. S. Zueva T. D. Kapyrina Wnt/β-catenin signaling pathway role in the endometriosis pathogenesis Акушерство, гинекология и репродукция endometriosis wnt/β-catenin signaling pathway cell proliferation fibrosis micrornas adhesion formation targeted therapy |
| title | Wnt/β-catenin signaling pathway role in the endometriosis pathogenesis |
| title_full | Wnt/β-catenin signaling pathway role in the endometriosis pathogenesis |
| title_fullStr | Wnt/β-catenin signaling pathway role in the endometriosis pathogenesis |
| title_full_unstemmed | Wnt/β-catenin signaling pathway role in the endometriosis pathogenesis |
| title_short | Wnt/β-catenin signaling pathway role in the endometriosis pathogenesis |
| title_sort | wnt β catenin signaling pathway role in the endometriosis pathogenesis |
| topic | endometriosis wnt/β-catenin signaling pathway cell proliferation fibrosis micrornas adhesion formation targeted therapy |
| url | https://www.gynecology.su/jour/article/view/2509 |
| work_keys_str_mv | AT evvirivskaya wntbcateninsignalingpathwayroleintheendometriosispathogenesis AT ivignatko wntbcateninsignalingpathwayroleintheendometriosispathogenesis AT iasnimshchikova wntbcateninsignalingpathwayroleintheendometriosispathogenesis AT krbakhtiyarov wntbcateninsignalingpathwayroleintheendometriosispathogenesis AT aszueva wntbcateninsignalingpathwayroleintheendometriosispathogenesis AT tdkapyrina wntbcateninsignalingpathwayroleintheendometriosispathogenesis |