Spontaneous dynamic modulation of ionic/immune microenvironment on polyetheretherketone for sequential anti-infection and osseointegration
Initial implant-related infection and subsequent poor osseointegration are the main causes of implant placement failure. The extracellular microenvironment is an important mediator of behaviors of cell and bacteria; however, spontaneously dynamically regulating the microenvironment to match tissue i...
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KeAi Communications Co., Ltd.
2025-12-01
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| Series: | Bioactive Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X25003548 |
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| author | Junjie Zhou Yinghao Wu Ji Tan Yisi Liu Jibing He Bowen Zheng Xiaohan Ma Xianming Zhang Jiaxing Wang Shiwei Guan Xin Ma Xiaochun Peng Xuanyong Liu |
| author_facet | Junjie Zhou Yinghao Wu Ji Tan Yisi Liu Jibing He Bowen Zheng Xiaohan Ma Xianming Zhang Jiaxing Wang Shiwei Guan Xin Ma Xiaochun Peng Xuanyong Liu |
| author_sort | Junjie Zhou |
| collection | DOAJ |
| description | Initial implant-related infection and subsequent poor osseointegration are the main causes of implant placement failure. The extracellular microenvironment is an important mediator of behaviors of cell and bacteria; however, spontaneously dynamically regulating the microenvironment to match tissue integration processes remains a challenge. Here, we construct a multilayer film on polyetheretherketone (PEEK) surface with different inner and outer layers of magnesium oxide (MgO) degradation rates. This film can sequentially regulate surface ions and immune microenvironment to achieve sequential antibacteria and bone integration. In the early stage of bone implantation, the outer layer of MgO can rapidly degrade to produce a strong alkaline microenvironment and a large amount of magnesium (Mg) ions, disrupting the energy metabolism of adherent bacteria and inducing M1 polarization of macrophages to enhance their ability to engulf planktonic bacteria. In the later stage, the inner layer MgO can slowly release Mg ion for a long time, synergistically promoting the proliferation and differentiation of osteoblasts by directly stimulating osteoblasts and inducing M2 polarization of macrophages. The rat femoral implantation model confirms the good sequential immune-enhanced antibacteria and bone integration ability of the film in vivo. In addition, the film can control the polarization time of cells by adjusting the thickness of the outer layer to meet the needs of different scenarios. This study demonstrates that the synergistic induction of ion microenvironment and immune microenvironment is a promising and safe surface modification strategy for bone implants. |
| format | Article |
| id | doaj-art-e114d065ca35491db5245670cb26bbb4 |
| institution | Kabale University |
| issn | 2452-199X |
| language | English |
| publishDate | 2025-12-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj-art-e114d065ca35491db5245670cb26bbb42025-08-26T04:14:27ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2025-12-015431132810.1016/j.bioactmat.2025.08.001Spontaneous dynamic modulation of ionic/immune microenvironment on polyetheretherketone for sequential anti-infection and osseointegrationJunjie Zhou0Yinghao Wu1Ji Tan2Yisi Liu3Jibing He4Bowen Zheng5Xiaohan Ma6Xianming Zhang7Jiaxing Wang8Shiwei Guan9Xin Ma10Xiaochun Peng11Xuanyong Liu12State Key Laboratory of High Performance Ceramics, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, China; Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing, 100049, ChinaShanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, ChinaState Key Laboratory of High Performance Ceramics, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, China; Corresponding author.State Key Laboratory of High Performance Ceramics, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, China; Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing, 100049, ChinaShanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, ChinaState Key Laboratory of High Performance Ceramics, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, ChinaState Key Laboratory of High Performance Ceramics, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, ChinaState Key Laboratory of High Performance Ceramics, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, ChinaShanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, ChinaState Key Laboratory of High Performance Ceramics, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, ChinaShanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, ChinaShanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China; Corresponding author.State Key Laboratory of High Performance Ceramics, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, China; School of Chemistry and Materials Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, 310024, China; Corresponding author. State Key Laboratory of High Performance Ceramics, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, China.Initial implant-related infection and subsequent poor osseointegration are the main causes of implant placement failure. The extracellular microenvironment is an important mediator of behaviors of cell and bacteria; however, spontaneously dynamically regulating the microenvironment to match tissue integration processes remains a challenge. Here, we construct a multilayer film on polyetheretherketone (PEEK) surface with different inner and outer layers of magnesium oxide (MgO) degradation rates. This film can sequentially regulate surface ions and immune microenvironment to achieve sequential antibacteria and bone integration. In the early stage of bone implantation, the outer layer of MgO can rapidly degrade to produce a strong alkaline microenvironment and a large amount of magnesium (Mg) ions, disrupting the energy metabolism of adherent bacteria and inducing M1 polarization of macrophages to enhance their ability to engulf planktonic bacteria. In the later stage, the inner layer MgO can slowly release Mg ion for a long time, synergistically promoting the proliferation and differentiation of osteoblasts by directly stimulating osteoblasts and inducing M2 polarization of macrophages. The rat femoral implantation model confirms the good sequential immune-enhanced antibacteria and bone integration ability of the film in vivo. In addition, the film can control the polarization time of cells by adjusting the thickness of the outer layer to meet the needs of different scenarios. This study demonstrates that the synergistic induction of ion microenvironment and immune microenvironment is a promising and safe surface modification strategy for bone implants.http://www.sciencedirect.com/science/article/pii/S2452199X25003548ImmunoregulationAlkaline microenvironmentAntibacteriaOsseointegrationPolyetheretherketone |
| spellingShingle | Junjie Zhou Yinghao Wu Ji Tan Yisi Liu Jibing He Bowen Zheng Xiaohan Ma Xianming Zhang Jiaxing Wang Shiwei Guan Xin Ma Xiaochun Peng Xuanyong Liu Spontaneous dynamic modulation of ionic/immune microenvironment on polyetheretherketone for sequential anti-infection and osseointegration Bioactive Materials Immunoregulation Alkaline microenvironment Antibacteria Osseointegration Polyetheretherketone |
| title | Spontaneous dynamic modulation of ionic/immune microenvironment on polyetheretherketone for sequential anti-infection and osseointegration |
| title_full | Spontaneous dynamic modulation of ionic/immune microenvironment on polyetheretherketone for sequential anti-infection and osseointegration |
| title_fullStr | Spontaneous dynamic modulation of ionic/immune microenvironment on polyetheretherketone for sequential anti-infection and osseointegration |
| title_full_unstemmed | Spontaneous dynamic modulation of ionic/immune microenvironment on polyetheretherketone for sequential anti-infection and osseointegration |
| title_short | Spontaneous dynamic modulation of ionic/immune microenvironment on polyetheretherketone for sequential anti-infection and osseointegration |
| title_sort | spontaneous dynamic modulation of ionic immune microenvironment on polyetheretherketone for sequential anti infection and osseointegration |
| topic | Immunoregulation Alkaline microenvironment Antibacteria Osseointegration Polyetheretherketone |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X25003548 |
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