Advancements in Corneal Transplantation: Addressing Rejection Risks, Innovations and Challenges
Introduction and Objective: Corneal transplantation is an increasingly common surgical procedure, with lamellar keratoplasty now favored over penetrating keratoplasty due to its advantages in outcomes and precision. Review methods: A literature review utilizing databases like Scopus, Google Sc...
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Nicolaus Copernicus University in Toruń
2024-12-01
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| Series: | Quality in Sport |
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| Online Access: | https://apcz.umk.pl/QS/article/view/56443 |
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| author | Daria Ziemińska Karina Motolko Rafał Burczyk Konrad Duszyński Elżbieta Tokarczyk |
| author_facet | Daria Ziemińska Karina Motolko Rafał Burczyk Konrad Duszyński Elżbieta Tokarczyk |
| author_sort | Daria Ziemińska |
| collection | DOAJ |
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Introduction and Objective:
Corneal transplantation is an increasingly common surgical procedure, with lamellar keratoplasty now favored over penetrating keratoplasty due to its advantages in outcomes and precision.
Review methods: A literature review utilizing databases like Scopus, Google Scholar, and PubMed, with keywords such as "corneal transplantation rejection" and "high risk of rejection," underscores the need for advancements in understanding and managing graft rejection.
Brief knowledge status: Key insights highlight the importance of deeper exploration into the immunological mechanisms of rejection to refine therapeutic strategies. The development of bioengineered materials like acellular porcine corneal stroma (APCS) offers a promising solution to the global donor shortage, though further validation of their clinical utility is needed. Complementary therapies such as amniotic membrane transplantation show promise in mitigating graft failure and treating corneal surface disorders due to their anti-inflammatory and regenerative properties. Moreover, comparative studies suggest that advanced keratoplasty techniques, such as Descemet Membrane Endothelial Keratoplasty (DMEK), may achieve lower rejection rates compared to alternatives like Descemet Stripping Automated Endothelial Keratoplasty (DSAEK).
Discussion: Future priorities include advancing drug delivery systems, ensuring the feasibility and accessibility of bioengineered materials, and conducting large-scale multicenter trials to validate novel treatments and surgical methods across diverse populations.
Summary: Addressing these challenges is particularly crucial for high-risk and pediatric patients, with the ultimate goal of reducing graft failure rates and the necessity for repeat interventions.
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| format | Article |
| id | doaj-art-e111d540ca034ec695c069f3091df518 |
| institution | DOAJ |
| issn | 2450-3118 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nicolaus Copernicus University in Toruń |
| record_format | Article |
| series | Quality in Sport |
| spelling | doaj-art-e111d540ca034ec695c069f3091df5182025-08-20T02:49:30ZengNicolaus Copernicus University in ToruńQuality in Sport2450-31182024-12-013510.12775/QS.2024.35.56443Advancements in Corneal Transplantation: Addressing Rejection Risks, Innovations and ChallengesDaria Ziemińska0https://orcid.org/0009-0001-8240-2593Karina Motolko1https://orcid.org/0009-0001-9971-6687Rafał Burczyk2https://orcid.org/0000-0002-1650-1534Konrad Duszyński3https://orcid.org/0009-0006-5524-8857Elżbieta Tokarczyk4https://orcid.org/0009-0003-9683-7699Szpital Św. Wincentego a Paulo w Gdyni, ul. Wójta Radtkego 1, 81-348 GdyniaSpecjalistyczny Szpital Miejski im. M. Kopernika w Toruniu, ul. Stefana Batorego 17/19, 87-100 ToruńSzpital Uniwersytecki nr 2 im. dr J. Biziela, ul. Ujejskiego 75, 85-168 BydgoszczStudenckie Koło Naukowe Okulistyki, Gdański Uniwersytet Medyczny, ul. Marii Skłodowskiej-Curie 3a, 80-210 GdańskSzpital św. Wincentego a Paulo w Gdyni, ul. Wójta Radtkego 1, 81-348 Gdynia Introduction and Objective: Corneal transplantation is an increasingly common surgical procedure, with lamellar keratoplasty now favored over penetrating keratoplasty due to its advantages in outcomes and precision. Review methods: A literature review utilizing databases like Scopus, Google Scholar, and PubMed, with keywords such as "corneal transplantation rejection" and "high risk of rejection," underscores the need for advancements in understanding and managing graft rejection. Brief knowledge status: Key insights highlight the importance of deeper exploration into the immunological mechanisms of rejection to refine therapeutic strategies. The development of bioengineered materials like acellular porcine corneal stroma (APCS) offers a promising solution to the global donor shortage, though further validation of their clinical utility is needed. Complementary therapies such as amniotic membrane transplantation show promise in mitigating graft failure and treating corneal surface disorders due to their anti-inflammatory and regenerative properties. Moreover, comparative studies suggest that advanced keratoplasty techniques, such as Descemet Membrane Endothelial Keratoplasty (DMEK), may achieve lower rejection rates compared to alternatives like Descemet Stripping Automated Endothelial Keratoplasty (DSAEK). Discussion: Future priorities include advancing drug delivery systems, ensuring the feasibility and accessibility of bioengineered materials, and conducting large-scale multicenter trials to validate novel treatments and surgical methods across diverse populations. Summary: Addressing these challenges is particularly crucial for high-risk and pediatric patients, with the ultimate goal of reducing graft failure rates and the necessity for repeat interventions. https://apcz.umk.pl/QS/article/view/56443corneal graft rejectioncorneal transplant rejectioncorneal transplantation rejectionpathophysiology of corneal graft rejectionbioengineered corneal materials |
| spellingShingle | Daria Ziemińska Karina Motolko Rafał Burczyk Konrad Duszyński Elżbieta Tokarczyk Advancements in Corneal Transplantation: Addressing Rejection Risks, Innovations and Challenges Quality in Sport corneal graft rejection corneal transplant rejection corneal transplantation rejection pathophysiology of corneal graft rejection bioengineered corneal materials |
| title | Advancements in Corneal Transplantation: Addressing Rejection Risks, Innovations and Challenges |
| title_full | Advancements in Corneal Transplantation: Addressing Rejection Risks, Innovations and Challenges |
| title_fullStr | Advancements in Corneal Transplantation: Addressing Rejection Risks, Innovations and Challenges |
| title_full_unstemmed | Advancements in Corneal Transplantation: Addressing Rejection Risks, Innovations and Challenges |
| title_short | Advancements in Corneal Transplantation: Addressing Rejection Risks, Innovations and Challenges |
| title_sort | advancements in corneal transplantation addressing rejection risks innovations and challenges |
| topic | corneal graft rejection corneal transplant rejection corneal transplantation rejection pathophysiology of corneal graft rejection bioengineered corneal materials |
| url | https://apcz.umk.pl/QS/article/view/56443 |
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