Glaucomatous retinal ganglion cells: death and protection
Glaucoma is a group of diseases characterized by progressive optic nerve degeneration, with the characteristic pathological change being death of retinal ganglion cells (RGCs), which ultimately causes visual field loss and irreversible blindness. Elevated intraocular pressure (IOP) remains the most...
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Press of International Journal of Ophthalmology (IJO PRESS)
2025-01-01
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| Series: | International Journal of Ophthalmology |
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| Online Access: | http://ies.ijo.cn/en_publish/2025/1/20250120.pdf |
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| author | Na Cui Jun Jia Yuan He |
| author_facet | Na Cui Jun Jia Yuan He |
| author_sort | Na Cui |
| collection | DOAJ |
| description | Glaucoma is a group of diseases characterized by progressive optic nerve degeneration, with the characteristic pathological change being death of retinal ganglion cells (RGCs), which ultimately causes visual field loss and irreversible blindness. Elevated intraocular pressure (IOP) remains the most important risk factor for glaucoma, but the exact mechanism responsible for the death of RGCs is currently unknown. Neurotrophic factor deficiency, impaired mitochondrial structure and function, disrupted axonal transport, disturbed Ca2+ homeostasis, and activation of apoptotic and autophagic pathways play important roles in RGC death in glaucoma. This review was conducted using Web of Science, PubMed, Project, and other databases to summarize the relevant mechanisms of death of RGCs in glaucoma, in addition to outlining protective treatments to improve the degradation of RGCs. |
| format | Article |
| id | doaj-art-e110953d1bf945878974840f789cdad3 |
| institution | Kabale University |
| issn | 2222-3959 2227-4898 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | International Journal of Ophthalmology |
| spelling | doaj-art-e110953d1bf945878974840f789cdad32024-12-18T07:46:07ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982025-01-0118116016710.18240/ijo.2025.01.2020250120Glaucomatous retinal ganglion cells: death and protectionNa Cui0Jun Jia1Yuan He2Yuan He. Department of Ophthalmology, the Second Affiliated Hospital of Xi'an Medical University, Xi'an 710038, Shaanxi Province, China. heyuan@xiyi.edu.cnDepartment of Ophthalmology, the Second Affiliated Hospital of Xi'an Medical University, Xi'an 710038, Shaanxi Province, China; Xi'an Key Laboratory for the Prevention and Treatment of Eye and Brain Neurological Related Diseases, Xi'an 710038, Shaanxi Province, ChinaDepartment of Ophthalmology, the Second Affiliated Hospital of Xi'an Medical University, Xi'an 710038, Shaanxi Province, China; Xi'an Key Laboratory for the Prevention and Treatment of Eye and Brain Neurological Related Diseases, Xi'an 710038, Shaanxi Province, ChinaGlaucoma is a group of diseases characterized by progressive optic nerve degeneration, with the characteristic pathological change being death of retinal ganglion cells (RGCs), which ultimately causes visual field loss and irreversible blindness. Elevated intraocular pressure (IOP) remains the most important risk factor for glaucoma, but the exact mechanism responsible for the death of RGCs is currently unknown. Neurotrophic factor deficiency, impaired mitochondrial structure and function, disrupted axonal transport, disturbed Ca2+ homeostasis, and activation of apoptotic and autophagic pathways play important roles in RGC death in glaucoma. This review was conducted using Web of Science, PubMed, Project, and other databases to summarize the relevant mechanisms of death of RGCs in glaucoma, in addition to outlining protective treatments to improve the degradation of RGCs.http://ies.ijo.cn/en_publish/2025/1/20250120.pdfglaucomaretinal ganglion cellsneuroprotectionprogressive deathaxonal deletion |
| spellingShingle | Na Cui Jun Jia Yuan He Glaucomatous retinal ganglion cells: death and protection International Journal of Ophthalmology glaucoma retinal ganglion cells neuroprotection progressive death axonal deletion |
| title | Glaucomatous retinal ganglion cells: death and protection |
| title_full | Glaucomatous retinal ganglion cells: death and protection |
| title_fullStr | Glaucomatous retinal ganglion cells: death and protection |
| title_full_unstemmed | Glaucomatous retinal ganglion cells: death and protection |
| title_short | Glaucomatous retinal ganglion cells: death and protection |
| title_sort | glaucomatous retinal ganglion cells death and protection |
| topic | glaucoma retinal ganglion cells neuroprotection progressive death axonal deletion |
| url | http://ies.ijo.cn/en_publish/2025/1/20250120.pdf |
| work_keys_str_mv | AT nacui glaucomatousretinalganglioncellsdeathandprotection AT junjia glaucomatousretinalganglioncellsdeathandprotection AT yuanhe glaucomatousretinalganglioncellsdeathandprotection |