Endoscopic Submucosal Dissection for Gastric Subepithelial Tumors: A Single-Center Experience
Background and Aims. Endoscopic submucosal dissection (ESD) has been accepted as a treatment modality for gastrointestinal epithelial tumors. Recently, ESD has been applied to resect subepithelial tumors (SETs) in the gastrointestinal tract, but clinical evidence on its efficacy and safety is limite...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2015/425469 |
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| author | Jin Sung Lee Gwang Ha Kim Do Youn Park Jong Min Yoon Tae Wook Kim Jong Hun Seo Bong Eun Lee Geun Am Song |
| author_facet | Jin Sung Lee Gwang Ha Kim Do Youn Park Jong Min Yoon Tae Wook Kim Jong Hun Seo Bong Eun Lee Geun Am Song |
| author_sort | Jin Sung Lee |
| collection | DOAJ |
| description | Background and Aims. Endoscopic submucosal dissection (ESD) has been accepted as a treatment modality for gastrointestinal epithelial tumors. Recently, ESD has been applied to resect subepithelial tumors (SETs) in the gastrointestinal tract, but clinical evidence on its efficacy and safety is limited. The aim of this study was to investigate the efficacy and safety of ESD for gastric SETs and to assess possible predictive factors for incomplete resection. Patients and Methods. Between January 2006 and December 2013, a total of 49 patients with gastric SET underwent ESD at our hospital. Clinicopathologic characteristics of patients and SETs, therapeutic outcomes, complications, and follow-up outcomes were evaluated. Results. The overall rates of en bloc resection and complete resection were 88% (43/49) and 84% (43/49), respectively. Complete resection rates in tumors originating from the submucosal layer were significantly higher than those in tumors originating from the muscularis propria layer (90% versus 56%, P=0.028). In multivariate logistic regression analyses, tumor location (upper third: odds ratio [OR] 12.639, 95% confidence interval [CI] 1.087–146.996, P=0.043) and layer of tumor origin (muscularis propria: OR 8.174, 95% CI 1.059–63.091, P=0.044) were independently associated with incomplete resection. Procedure-related bleeding and perforation rates were both 4%. No recurrence was observed in patients with complete resection at a median follow-up period of 29 months (range: 7–83 months). Conclusions. ESD is an effective, safe, and feasible treatment for gastric SETs. The frequency of incomplete resection increases in tumors located in the upper third of the stomach and in those originating from the muscularis propria layer. |
| format | Article |
| id | doaj-art-e10c3ee24b8e42bda84e56e4c6445eda |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-e10c3ee24b8e42bda84e56e4c6445eda2025-02-03T01:25:35ZengWileyGastroenterology Research and Practice1687-61211687-630X2015-01-01201510.1155/2015/425469425469Endoscopic Submucosal Dissection for Gastric Subepithelial Tumors: A Single-Center ExperienceJin Sung Lee0Gwang Ha Kim1Do Youn Park2Jong Min Yoon3Tae Wook Kim4Jong Hun Seo5Bong Eun Lee6Geun Am Song7Department of Internal Medicine, Pusan National University School of Medicine, Busan 602-739, Republic of KoreaDepartment of Internal Medicine, Pusan National University School of Medicine, Busan 602-739, Republic of KoreaBiomedical Research Institute, Pusan National University Hospital, Busan 602-739, Republic of KoreaDepartment of Internal Medicine, Pusan National University School of Medicine, Busan 602-739, Republic of KoreaDepartment of Internal Medicine, Pusan National University School of Medicine, Busan 602-739, Republic of KoreaDepartment of Internal Medicine, Pusan National University School of Medicine, Busan 602-739, Republic of KoreaDepartment of Internal Medicine, Pusan National University School of Medicine, Busan 602-739, Republic of KoreaDepartment of Internal Medicine, Pusan National University School of Medicine, Busan 602-739, Republic of KoreaBackground and Aims. Endoscopic submucosal dissection (ESD) has been accepted as a treatment modality for gastrointestinal epithelial tumors. Recently, ESD has been applied to resect subepithelial tumors (SETs) in the gastrointestinal tract, but clinical evidence on its efficacy and safety is limited. The aim of this study was to investigate the efficacy and safety of ESD for gastric SETs and to assess possible predictive factors for incomplete resection. Patients and Methods. Between January 2006 and December 2013, a total of 49 patients with gastric SET underwent ESD at our hospital. Clinicopathologic characteristics of patients and SETs, therapeutic outcomes, complications, and follow-up outcomes were evaluated. Results. The overall rates of en bloc resection and complete resection were 88% (43/49) and 84% (43/49), respectively. Complete resection rates in tumors originating from the submucosal layer were significantly higher than those in tumors originating from the muscularis propria layer (90% versus 56%, P=0.028). In multivariate logistic regression analyses, tumor location (upper third: odds ratio [OR] 12.639, 95% confidence interval [CI] 1.087–146.996, P=0.043) and layer of tumor origin (muscularis propria: OR 8.174, 95% CI 1.059–63.091, P=0.044) were independently associated with incomplete resection. Procedure-related bleeding and perforation rates were both 4%. No recurrence was observed in patients with complete resection at a median follow-up period of 29 months (range: 7–83 months). Conclusions. ESD is an effective, safe, and feasible treatment for gastric SETs. The frequency of incomplete resection increases in tumors located in the upper third of the stomach and in those originating from the muscularis propria layer.http://dx.doi.org/10.1155/2015/425469 |
| spellingShingle | Jin Sung Lee Gwang Ha Kim Do Youn Park Jong Min Yoon Tae Wook Kim Jong Hun Seo Bong Eun Lee Geun Am Song Endoscopic Submucosal Dissection for Gastric Subepithelial Tumors: A Single-Center Experience Gastroenterology Research and Practice |
| title | Endoscopic Submucosal Dissection for Gastric Subepithelial Tumors: A Single-Center Experience |
| title_full | Endoscopic Submucosal Dissection for Gastric Subepithelial Tumors: A Single-Center Experience |
| title_fullStr | Endoscopic Submucosal Dissection for Gastric Subepithelial Tumors: A Single-Center Experience |
| title_full_unstemmed | Endoscopic Submucosal Dissection for Gastric Subepithelial Tumors: A Single-Center Experience |
| title_short | Endoscopic Submucosal Dissection for Gastric Subepithelial Tumors: A Single-Center Experience |
| title_sort | endoscopic submucosal dissection for gastric subepithelial tumors a single center experience |
| url | http://dx.doi.org/10.1155/2015/425469 |
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