Transcranial magnetic stimulation measures of corticospinal excitability in Black and Hispanic/Latino people with painful peripheral neuropathy
IntroductionThis study aims to provide preliminary descriptive data on transcranial magnetic stimulation (TMS) measures obtained in Black and Hispanic/Latino individuals with chronic painful peripheral neuropathy (PN), including those with chemotherapy-induced peripheral neuropathy (CIPN) and diabet...
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Frontiers Media S.A.
2025-06-01
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| author | Marlon L. Wong Lisa M. McTeague Gabriel Gonzalez Juan P. Gonzalez Jessica L. Bolanos Peter J. Hosein Danylo F. Cabral Peter J. Fried |
| author_facet | Marlon L. Wong Lisa M. McTeague Gabriel Gonzalez Juan P. Gonzalez Jessica L. Bolanos Peter J. Hosein Danylo F. Cabral Peter J. Fried |
| author_sort | Marlon L. Wong |
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| description | IntroductionThis study aims to provide preliminary descriptive data on transcranial magnetic stimulation (TMS) measures obtained in Black and Hispanic/Latino individuals with chronic painful peripheral neuropathy (PN), including those with chemotherapy-induced peripheral neuropathy (CIPN) and diabetic neuropathy (DN). Both CIPN and DN share similar neuropathic symptoms and underlying physiological mechanisms, in particular altered central nervous system processing. TMS is a non-invasive technique that can assess corticospinal excitability and the function of GABAergic and glutamatergic pathways, potentially serving as a diagnostic or prognostic tool for PN.MethodsThis study utilized data from a pilot randomized sham-controlled trial that tested the impact of patient education videos on the effect of transcutaneous auricular vagus nerve stimulation (taVNS) in Black and Hispanic/Latino individuals living with PN. TMS measures, including resting motor threshold (RMT), MEP amplitude following unconditioned single-pulse TMS (spTMS) and paired-pulse TMS measures of short interval intracortical inhibition (SICI), and intracortical facilitation (ICF), were assessed twice on separate visits. Test-retest reliability was evaluated, and changes in TMS measures following transcutaneous auricular vagus nerve stimulation were computed.ResultsPre-intervention TMS measures showed smaller-than-medium sized differences between CIPN and DN groups. The study found good test-retest reliability for TMS measures, with ICC values between 0.69 and 0.95 for all TMS measures of interest.DiscussionOverall, TMS measures demonstrated good reliability in this sample of Black and Hispanic/Latino individuals with PN, and these findings provide valuable preliminary data for future studies aimed at establishing the psychometric properties and diagnostic utility of TMS measures in PN. |
| format | Article |
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| issn | 1662-5161 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Human Neuroscience |
| spelling | doaj-art-e10a870ce10548d5aee604ba3ca10ab62025-08-20T03:20:29ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612025-06-011910.3389/fnhum.2025.15519311551931Transcranial magnetic stimulation measures of corticospinal excitability in Black and Hispanic/Latino people with painful peripheral neuropathyMarlon L. Wong0Lisa M. McTeague1Gabriel Gonzalez2Juan P. Gonzalez3Jessica L. Bolanos4Peter J. Hosein5Danylo F. Cabral6Peter J. Fried7Department of Physical Therapy, University of Miami, Coral Gables, FL, United StatesDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, United StatesDepartment of Physical Therapy, University of Miami, Coral Gables, FL, United StatesDepartment of Physical Therapy, University of Miami, Coral Gables, FL, United StatesDepartment of Physical Therapy, University of Miami, Coral Gables, FL, United StatesDepartment of Physical Therapy, University of Miami, Coral Gables, FL, United StatesHarvard Medical School Department of Neurology, Berenson-Allen Center for Noninvasive Brain Stimulation, Boston, ML, United StatesHarvard Medical School Department of Neurology, Berenson-Allen Center for Noninvasive Brain Stimulation, Boston, ML, United StatesIntroductionThis study aims to provide preliminary descriptive data on transcranial magnetic stimulation (TMS) measures obtained in Black and Hispanic/Latino individuals with chronic painful peripheral neuropathy (PN), including those with chemotherapy-induced peripheral neuropathy (CIPN) and diabetic neuropathy (DN). Both CIPN and DN share similar neuropathic symptoms and underlying physiological mechanisms, in particular altered central nervous system processing. TMS is a non-invasive technique that can assess corticospinal excitability and the function of GABAergic and glutamatergic pathways, potentially serving as a diagnostic or prognostic tool for PN.MethodsThis study utilized data from a pilot randomized sham-controlled trial that tested the impact of patient education videos on the effect of transcutaneous auricular vagus nerve stimulation (taVNS) in Black and Hispanic/Latino individuals living with PN. TMS measures, including resting motor threshold (RMT), MEP amplitude following unconditioned single-pulse TMS (spTMS) and paired-pulse TMS measures of short interval intracortical inhibition (SICI), and intracortical facilitation (ICF), were assessed twice on separate visits. Test-retest reliability was evaluated, and changes in TMS measures following transcutaneous auricular vagus nerve stimulation were computed.ResultsPre-intervention TMS measures showed smaller-than-medium sized differences between CIPN and DN groups. The study found good test-retest reliability for TMS measures, with ICC values between 0.69 and 0.95 for all TMS measures of interest.DiscussionOverall, TMS measures demonstrated good reliability in this sample of Black and Hispanic/Latino individuals with PN, and these findings provide valuable preliminary data for future studies aimed at establishing the psychometric properties and diagnostic utility of TMS measures in PN.https://www.frontiersin.org/articles/10.3389/fnhum.2025.1551931/fulltranscranial magnetic stimulationperipheral neuropathydiabetic neuropathychemotherapy induced peripheral neuropathyhealth disparities |
| spellingShingle | Marlon L. Wong Lisa M. McTeague Gabriel Gonzalez Juan P. Gonzalez Jessica L. Bolanos Peter J. Hosein Danylo F. Cabral Peter J. Fried Transcranial magnetic stimulation measures of corticospinal excitability in Black and Hispanic/Latino people with painful peripheral neuropathy Frontiers in Human Neuroscience transcranial magnetic stimulation peripheral neuropathy diabetic neuropathy chemotherapy induced peripheral neuropathy health disparities |
| title | Transcranial magnetic stimulation measures of corticospinal excitability in Black and Hispanic/Latino people with painful peripheral neuropathy |
| title_full | Transcranial magnetic stimulation measures of corticospinal excitability in Black and Hispanic/Latino people with painful peripheral neuropathy |
| title_fullStr | Transcranial magnetic stimulation measures of corticospinal excitability in Black and Hispanic/Latino people with painful peripheral neuropathy |
| title_full_unstemmed | Transcranial magnetic stimulation measures of corticospinal excitability in Black and Hispanic/Latino people with painful peripheral neuropathy |
| title_short | Transcranial magnetic stimulation measures of corticospinal excitability in Black and Hispanic/Latino people with painful peripheral neuropathy |
| title_sort | transcranial magnetic stimulation measures of corticospinal excitability in black and hispanic latino people with painful peripheral neuropathy |
| topic | transcranial magnetic stimulation peripheral neuropathy diabetic neuropathy chemotherapy induced peripheral neuropathy health disparities |
| url | https://www.frontiersin.org/articles/10.3389/fnhum.2025.1551931/full |
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