Large-scale CRISPRi screens link metabolic stress to glioblastoma chemoresistance

Large-scale CRISPRi screens link metabolic stress to glioblastoma chemoresistance

Abstract Background Glioblastoma (GBM) patients frequently develop resistance to temozolomide (TMZ), the standard chemotherapy. While targeting cancer metabolism shows promise, the relationship between metabolic perturbation and drug resistance remains poorly understood. Methods We performed high-th...

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Bibliographic Details
Main Authors: Xing Li, Wansong Zhang, Yitong Fang, Tianhu Sun, Jian Chen, Ruilin Tian
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Journal of Translational Medicine
Subjects:
Glioblastoma
Temozolomide resistance
PGK1
Metabolic stress
CRISPR screening
DNA damage repair
Online Access:https://doi.org/10.1186/s12967-025-06261-4
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