Variant mutation G215C in SARS-CoV-2 nucleocapsid enhances viral infection via altered genomic encapsidation.

Variant mutation G215C in SARS-CoV-2 nucleocapsid enhances viral infection via altered genomic encapsidation.

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The evolution of SARS-CoV-2 variants and their respective phenotypes represents an important set of tools to understand basic coronavirus biology as well as the public health implications of individual mutations in variants of concern. While mutations outside of spike are not well studied, the entir...

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Main Authors: Hannah C Kubinski, Hannah W Despres, Bryan A Johnson, Madaline M Schmidt, Sara A Jaffrani, Allyson H Turner, Conor D Fanuele, Margaret G Mills, Kumari G Lokugamage, Caroline M Dumas, David J Shirley, Leah K Estes, Andrew Pekosz, Jessica W Crothers, Pavitra Roychoudhury, Alexander L Greninger, Keith R Jerome, Bruno Martorelli Di Genova, David H Walker, Bryan A Ballif, Mark S Ladinsky, Pamela J Bjorkman, Vineet D Menachery, Emily A Bruce
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-04-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3003115
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https://doi.org/10.1371/journal.pbio.3003115

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