Non-Invasive Wearables in Inflammation Monitoring: From Biomarkers to Biosensors
Quantifying inflammation plays a critical role in understanding the progression and development of various diseases. Non-invasive or minimally invasive wearable biosensors have garnered significant attention in recent years due to their convenience, comfort, and ability to provide continuous monitor...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-06-01
|
| Series: | Biosensors |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6374/15/6/351 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849432756204863488 |
|---|---|
| author | Tingting Wu Guozhen Liu |
| author_facet | Tingting Wu Guozhen Liu |
| author_sort | Tingting Wu |
| collection | DOAJ |
| description | Quantifying inflammation plays a critical role in understanding the progression and development of various diseases. Non-invasive or minimally invasive wearable biosensors have garnered significant attention in recent years due to their convenience, comfort, and ability to provide continuous monitoring of biomarkers, particularly in infectious diseases and chronic diseases. However, there are still areas for improvement in developing reliable biosensing devices to detect key inflammatory biomarkers in clinically relevant biofluids. This review first introduces common biofluids with a focus on the most clinically significant inflammatory biomarkers. Specifically, it discusses the challenges encountered in extracting and detecting analytes in these biofluids. Subsequently, we review three popular types of non-invasive wearable biosensors for inflammation monitoring (microneedle patches, flexible electronic skins, and textile-based sensors). The design and operational considerations of these devices are analyzed, followed by an exploration of the information processing approaches employed during data processing. Finally, we envision future opportunities by guiding the development and refinement of non-invasive or minimally invasive wearable biosensors for continuous inflammation monitoring in chronic diseases. |
| format | Article |
| id | doaj-art-e1058abc74014914b27f028125dce5c0 |
| institution | Kabale University |
| issn | 2079-6374 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj-art-e1058abc74014914b27f028125dce5c02025-08-20T03:27:17ZengMDPI AGBiosensors2079-63742025-06-0115635110.3390/bios15060351Non-Invasive Wearables in Inflammation Monitoring: From Biomarkers to BiosensorsTingting Wu0Guozhen Liu1Integrated Devices and Intelligent Diagnosis (ID<sup>2</sup>) Laboratory, School of Medicine, The Chinese University of Hong Kong, Shenzhen 518172, ChinaIntegrated Devices and Intelligent Diagnosis (ID<sup>2</sup>) Laboratory, School of Medicine, The Chinese University of Hong Kong, Shenzhen 518172, ChinaQuantifying inflammation plays a critical role in understanding the progression and development of various diseases. Non-invasive or minimally invasive wearable biosensors have garnered significant attention in recent years due to their convenience, comfort, and ability to provide continuous monitoring of biomarkers, particularly in infectious diseases and chronic diseases. However, there are still areas for improvement in developing reliable biosensing devices to detect key inflammatory biomarkers in clinically relevant biofluids. This review first introduces common biofluids with a focus on the most clinically significant inflammatory biomarkers. Specifically, it discusses the challenges encountered in extracting and detecting analytes in these biofluids. Subsequently, we review three popular types of non-invasive wearable biosensors for inflammation monitoring (microneedle patches, flexible electronic skins, and textile-based sensors). The design and operational considerations of these devices are analyzed, followed by an exploration of the information processing approaches employed during data processing. Finally, we envision future opportunities by guiding the development and refinement of non-invasive or minimally invasive wearable biosensors for continuous inflammation monitoring in chronic diseases.https://www.mdpi.com/2079-6374/15/6/351inflammationwearable sensorsnon-invasive diagnosticsbiomarkersbiological fluids |
| spellingShingle | Tingting Wu Guozhen Liu Non-Invasive Wearables in Inflammation Monitoring: From Biomarkers to Biosensors Biosensors inflammation wearable sensors non-invasive diagnostics biomarkers biological fluids |
| title | Non-Invasive Wearables in Inflammation Monitoring: From Biomarkers to Biosensors |
| title_full | Non-Invasive Wearables in Inflammation Monitoring: From Biomarkers to Biosensors |
| title_fullStr | Non-Invasive Wearables in Inflammation Monitoring: From Biomarkers to Biosensors |
| title_full_unstemmed | Non-Invasive Wearables in Inflammation Monitoring: From Biomarkers to Biosensors |
| title_short | Non-Invasive Wearables in Inflammation Monitoring: From Biomarkers to Biosensors |
| title_sort | non invasive wearables in inflammation monitoring from biomarkers to biosensors |
| topic | inflammation wearable sensors non-invasive diagnostics biomarkers biological fluids |
| url | https://www.mdpi.com/2079-6374/15/6/351 |
| work_keys_str_mv | AT tingtingwu noninvasivewearablesininflammationmonitoringfrombiomarkerstobiosensors AT guozhenliu noninvasivewearablesininflammationmonitoringfrombiomarkerstobiosensors |