Evaluating the impact of testosterone replacement therapy on carotid atherosclerosis: a systematic review and meta-analysis
Aim: This meta-analysis investigates the association between testosterone replacement therapy [TRT] and carotid artery atherosclerosis. Methods: 3 databases were searched for studies up to June 2023 per the PRISMA guidelines. The eligibility criteria comprised RCTs and observational studies involvin...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Future Science OA |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/20565623.2024.2365125 |
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| author | Syed Hamza Haider Areeka Irfan Samir Mustafa Sheikh Muhammad Taha Abid Turba Naz Mudassir Abbas Alishba Raza |
| author_facet | Syed Hamza Haider Areeka Irfan Samir Mustafa Sheikh Muhammad Taha Abid Turba Naz Mudassir Abbas Alishba Raza |
| author_sort | Syed Hamza Haider |
| collection | DOAJ |
| description | Aim: This meta-analysis investigates the association between testosterone replacement therapy [TRT] and carotid artery atherosclerosis. Methods: 3 databases were searched for studies up to June 2023 per the PRISMA guidelines. The eligibility criteria comprised RCTs and observational studies involving hypogonadal males receiving exogenous testosterone, in which CIMT was assessed. CAA was the primary outcome, whereas secondary outcomes included HDL, LDL, CRP, total cholesterol and total testosterone. The statistical analysis was performed using Review Manager. Results: Statistical analysis revealed no association between TRT and assessed outcomes. There was a significant increase in total testosterone levels, depicting indirect anti-atherosclerotic effects of TRT. Conclusion: Meta-analysis shows no relation between TRT and CIMT or other markers, allowing its safe usage for hypogonadal males. |
| format | Article |
| id | doaj-art-e1035802a70841a9bdf9e9867c67c288 |
| institution | Kabale University |
| issn | 2056-5623 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Future Science OA |
| spelling | doaj-art-e1035802a70841a9bdf9e9867c67c2882025-08-20T03:27:48ZengTaylor & Francis GroupFuture Science OA2056-56232024-12-0110110.1080/20565623.2024.2365125Evaluating the impact of testosterone replacement therapy on carotid atherosclerosis: a systematic review and meta-analysisSyed Hamza Haider0Areeka Irfan1Samir Mustafa Sheikh2Muhammad Taha Abid3Turba Naz4Mudassir Abbas5Alishba Raza6MBBS, Department of Internal Medicine, Dow Medical College, Dow University of Health Sciences, V246+X8C, Mission Rd, Nanakwara, 74200, Karachi, PakistanMBBS, Department of Internal Medicine, Dow Medical College, Dow University of Health Sciences, V246+X8C, Mission Rd, Nanakwara, 74200, Karachi, PakistanMBBS, Department of Internal Medicine, Dow Medical College, Dow University of Health Sciences, V246+X8C, Mission Rd, Nanakwara, 74200, Karachi, PakistanMBBS, Department of Internal Medicine, Dow Medical College, Dow University of Health Sciences, V246+X8C, Mission Rd, Nanakwara, 74200, Karachi, PakistanMBBS, Department of Internal Medicine, Dow Medical College, Dow University of Health Sciences, V246+X8C, Mission Rd, Nanakwara, 74200, Karachi, PakistanMBBS, Department of Internal Medicine, Dow Medical College, Dow University of Health Sciences, V246+X8C, Mission Rd, Nanakwara, 74200, Karachi, PakistanMBBS, Department of Internal Medicine, Dow Medical College, Dow University of Health Sciences, V246+X8C, Mission Rd, Nanakwara, 74200, Karachi, PakistanAim: This meta-analysis investigates the association between testosterone replacement therapy [TRT] and carotid artery atherosclerosis. Methods: 3 databases were searched for studies up to June 2023 per the PRISMA guidelines. The eligibility criteria comprised RCTs and observational studies involving hypogonadal males receiving exogenous testosterone, in which CIMT was assessed. CAA was the primary outcome, whereas secondary outcomes included HDL, LDL, CRP, total cholesterol and total testosterone. The statistical analysis was performed using Review Manager. Results: Statistical analysis revealed no association between TRT and assessed outcomes. There was a significant increase in total testosterone levels, depicting indirect anti-atherosclerotic effects of TRT. Conclusion: Meta-analysis shows no relation between TRT and CIMT or other markers, allowing its safe usage for hypogonadal males.https://www.tandfonline.com/doi/10.1080/20565623.2024.2365125atherosclerosiscarotid arterycarotid intima media thicknessexogenous testosteronehormone replacement therapyhypogonadal males |
| spellingShingle | Syed Hamza Haider Areeka Irfan Samir Mustafa Sheikh Muhammad Taha Abid Turba Naz Mudassir Abbas Alishba Raza Evaluating the impact of testosterone replacement therapy on carotid atherosclerosis: a systematic review and meta-analysis Future Science OA atherosclerosis carotid artery carotid intima media thickness exogenous testosterone hormone replacement therapy hypogonadal males |
| title | Evaluating the impact of testosterone replacement therapy on carotid atherosclerosis: a systematic review and meta-analysis |
| title_full | Evaluating the impact of testosterone replacement therapy on carotid atherosclerosis: a systematic review and meta-analysis |
| title_fullStr | Evaluating the impact of testosterone replacement therapy on carotid atherosclerosis: a systematic review and meta-analysis |
| title_full_unstemmed | Evaluating the impact of testosterone replacement therapy on carotid atherosclerosis: a systematic review and meta-analysis |
| title_short | Evaluating the impact of testosterone replacement therapy on carotid atherosclerosis: a systematic review and meta-analysis |
| title_sort | evaluating the impact of testosterone replacement therapy on carotid atherosclerosis a systematic review and meta analysis |
| topic | atherosclerosis carotid artery carotid intima media thickness exogenous testosterone hormone replacement therapy hypogonadal males |
| url | https://www.tandfonline.com/doi/10.1080/20565623.2024.2365125 |
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