Age-related changes in the vestibulothalamic pathway: Association with balance ability and subjective visual vertical of vestibular function
Introduction: The thalamus regulates various sensory information to each related brain area. The vestibular nucleus transmits information of motor control to the thalamus regulating coordination function. The vestibulothalamic tract (VTT) is a neural pathway between the vestibular nucleus and thalam...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-02-01
|
| Series: | Brain Research Bulletin |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0361923025000218 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1825206985676554240 |
|---|---|
| author | Sang Seok Yeo Seo Yoon Park In Hee Cho |
| author_facet | Sang Seok Yeo Seo Yoon Park In Hee Cho |
| author_sort | Sang Seok Yeo |
| collection | DOAJ |
| description | Introduction: The thalamus regulates various sensory information to each related brain area. The vestibular nucleus transmits information of motor control to the thalamus regulating coordination function. The vestibulothalamic tract (VTT) is a neural pathway between the vestibular nucleus and thalamus that processes vestibular information for postural balance and spatial perception. Therefore, this study analyzed ipsilateral VTT to compare the neural pathway and the differences in vestibular and balance functions according to aging. Methods: Eleven elderly and 12 young healthy adults were recruited. This study measured subjective visual vertical (SVV) for vestibular function and body sway during one-leg standing. The ipsilateral VTT were reconstructed to investigate changes of neural pathway between two groups using diffusion tensor imaging. Results: Track volume of left and right VTTs was significantly more in the young healthy adults. In eyes-open (EO) condition during one-leg standing, the body sway demonstrated significant differences between two groups. In the eyes-closed (EC) condition, the degree of hip sway was decreased in the young healthy adults. In the EO condition, the body sway except for antero-posterior direction was significantly correlated with VTT. Meanwhile, in the EC condition, hip sway and all values of body sway were negatively correlated with VTT. In addition, the VTT revealed a negative correlation with SVV. Conclusions: The tract volume of VTT and static balance decreased according to aging. The changes of VTT also affected verticality perception and static balance. Therefore, the study could be helpful in providing the data for patients with thalamus or vestibular injury. |
| format | Article |
| id | doaj-art-e10205467a794d4b9880d75b8e1a069e |
| institution | Kabale University |
| issn | 1873-2747 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Research Bulletin |
| spelling | doaj-art-e10205467a794d4b9880d75b8e1a069e2025-02-07T04:46:43ZengElsevierBrain Research Bulletin1873-27472025-02-01221111209Age-related changes in the vestibulothalamic pathway: Association with balance ability and subjective visual vertical of vestibular functionSang Seok Yeo0Seo Yoon Park1In Hee Cho2Department of Physical Therapy, College of Health Sciences, Dankook University, Republic of KoreaDepartment of Physical Therapy, College of Health and Welfare, Woosuk University, 443 Samnye-ro, Samnye-eup, Wanju-gun 55338, Republic of KoreaDepartment of Health, Graduate School, Dankook University, 119, Dandae-ro, Dongnam-gu, Cheonan-si, Chungnam 31116, Republic of Korea; Corresponding author.Introduction: The thalamus regulates various sensory information to each related brain area. The vestibular nucleus transmits information of motor control to the thalamus regulating coordination function. The vestibulothalamic tract (VTT) is a neural pathway between the vestibular nucleus and thalamus that processes vestibular information for postural balance and spatial perception. Therefore, this study analyzed ipsilateral VTT to compare the neural pathway and the differences in vestibular and balance functions according to aging. Methods: Eleven elderly and 12 young healthy adults were recruited. This study measured subjective visual vertical (SVV) for vestibular function and body sway during one-leg standing. The ipsilateral VTT were reconstructed to investigate changes of neural pathway between two groups using diffusion tensor imaging. Results: Track volume of left and right VTTs was significantly more in the young healthy adults. In eyes-open (EO) condition during one-leg standing, the body sway demonstrated significant differences between two groups. In the eyes-closed (EC) condition, the degree of hip sway was decreased in the young healthy adults. In the EO condition, the body sway except for antero-posterior direction was significantly correlated with VTT. Meanwhile, in the EC condition, hip sway and all values of body sway were negatively correlated with VTT. In addition, the VTT revealed a negative correlation with SVV. Conclusions: The tract volume of VTT and static balance decreased according to aging. The changes of VTT also affected verticality perception and static balance. Therefore, the study could be helpful in providing the data for patients with thalamus or vestibular injury.http://www.sciencedirect.com/science/article/pii/S0361923025000218AgingVestibulothalamic tractSubjective visual verticalStatic balanceDiffusion tensor imaging |
| spellingShingle | Sang Seok Yeo Seo Yoon Park In Hee Cho Age-related changes in the vestibulothalamic pathway: Association with balance ability and subjective visual vertical of vestibular function Brain Research Bulletin Aging Vestibulothalamic tract Subjective visual vertical Static balance Diffusion tensor imaging |
| title | Age-related changes in the vestibulothalamic pathway: Association with balance ability and subjective visual vertical of vestibular function |
| title_full | Age-related changes in the vestibulothalamic pathway: Association with balance ability and subjective visual vertical of vestibular function |
| title_fullStr | Age-related changes in the vestibulothalamic pathway: Association with balance ability and subjective visual vertical of vestibular function |
| title_full_unstemmed | Age-related changes in the vestibulothalamic pathway: Association with balance ability and subjective visual vertical of vestibular function |
| title_short | Age-related changes in the vestibulothalamic pathway: Association with balance ability and subjective visual vertical of vestibular function |
| title_sort | age related changes in the vestibulothalamic pathway association with balance ability and subjective visual vertical of vestibular function |
| topic | Aging Vestibulothalamic tract Subjective visual vertical Static balance Diffusion tensor imaging |
| url | http://www.sciencedirect.com/science/article/pii/S0361923025000218 |
| work_keys_str_mv | AT sangseokyeo agerelatedchangesinthevestibulothalamicpathwayassociationwithbalanceabilityandsubjectivevisualverticalofvestibularfunction AT seoyoonpark agerelatedchangesinthevestibulothalamicpathwayassociationwithbalanceabilityandsubjectivevisualverticalofvestibularfunction AT inheecho agerelatedchangesinthevestibulothalamicpathwayassociationwithbalanceabilityandsubjectivevisualverticalofvestibularfunction |