Diagnosis of infantile subglottic hemangioma: a 10-year experience of 25 cases
ObjectivesThis study aims to explore the clinical appearances of infantile subglottic hemangioma (SGH) and the diagnostic value of flexible fiberoptic laryngoscopy (FFL) combined with contrast-enhanced CT (CECT).MethodsWe retrospectively analyzed the data of 25 children diagnosed with SGH from Janua...
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2025.1499656/full |
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| author | Xiaoben Liang Rong Xu Hongming Xu Jiarui Chen Xiaoyan Li |
| author_facet | Xiaoben Liang Rong Xu Hongming Xu Jiarui Chen Xiaoyan Li |
| author_sort | Xiaoben Liang |
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| description | ObjectivesThis study aims to explore the clinical appearances of infantile subglottic hemangioma (SGH) and the diagnostic value of flexible fiberoptic laryngoscopy (FFL) combined with contrast-enhanced CT (CECT).MethodsWe retrospectively analyzed the data of 25 children diagnosed with SGH from January 2012 to January 2022.ResultsFFL showed a smooth, rounded, vascular-appearing submucosal lesion in the subglottic wall, while CECT revealed an enhancing lesion, obscuring the airway lumen. Among the 25 cases (8 males and 17 females; 10 left-sided, 11 right-sided, and 4 middle), the clinical appearances contained stridor (25), respiratory distress (13), three-concave sign (10), barking cough (9), feeding difficulty (8), cyanosis (2), and hoarseness (2). SGH with cutaneous hemangiomas accounted for 24% (6/25). The age at presentation ranged from 1 day to 8 months (median, 33 days), including 96% (24/25) of cases aged <6 months. Moreover, 92% (23/25) of cases had a history of misdiagnosis, 22 respiratory infections, 5 laryngomalacia, 1 laryngeal cyst, and 1 asthma, individually or in combination. Except for one case that died of polygenic abnormality and another case lost to follow-up, the remaining 23 cases were cured after oral propranolol.ConclusionsFor an infant with respiratory symptoms, who has repeated condition or poor effect after routine treatment, SGH should be considered, especially in infants under 6 months old. FFL combined with CECT is recommended to make a definite diagnosis of SGH. |
| format | Article |
| id | doaj-art-e10033adffe844b787ef6a74486176e5 |
| institution | DOAJ |
| issn | 2296-2360 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Pediatrics |
| spelling | doaj-art-e10033adffe844b787ef6a74486176e52025-08-20T03:05:46ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602025-05-011310.3389/fped.2025.14996561499656Diagnosis of infantile subglottic hemangioma: a 10-year experience of 25 casesXiaoben Liang0Rong Xu1Hongming Xu2Jiarui Chen3Xiaoyan Li4Department of Otolaryngology-Head and Neck Surgery, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaDepartment of Radiology, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaObjectivesThis study aims to explore the clinical appearances of infantile subglottic hemangioma (SGH) and the diagnostic value of flexible fiberoptic laryngoscopy (FFL) combined with contrast-enhanced CT (CECT).MethodsWe retrospectively analyzed the data of 25 children diagnosed with SGH from January 2012 to January 2022.ResultsFFL showed a smooth, rounded, vascular-appearing submucosal lesion in the subglottic wall, while CECT revealed an enhancing lesion, obscuring the airway lumen. Among the 25 cases (8 males and 17 females; 10 left-sided, 11 right-sided, and 4 middle), the clinical appearances contained stridor (25), respiratory distress (13), three-concave sign (10), barking cough (9), feeding difficulty (8), cyanosis (2), and hoarseness (2). SGH with cutaneous hemangiomas accounted for 24% (6/25). The age at presentation ranged from 1 day to 8 months (median, 33 days), including 96% (24/25) of cases aged <6 months. Moreover, 92% (23/25) of cases had a history of misdiagnosis, 22 respiratory infections, 5 laryngomalacia, 1 laryngeal cyst, and 1 asthma, individually or in combination. Except for one case that died of polygenic abnormality and another case lost to follow-up, the remaining 23 cases were cured after oral propranolol.ConclusionsFor an infant with respiratory symptoms, who has repeated condition or poor effect after routine treatment, SGH should be considered, especially in infants under 6 months old. FFL combined with CECT is recommended to make a definite diagnosis of SGH.https://www.frontiersin.org/articles/10.3389/fped.2025.1499656/fullsubglottic hemangiomaflexible fiberoptic laryngoscopycontrast-enhanced computed tomographyinfantdiagnosis |
| spellingShingle | Xiaoben Liang Rong Xu Hongming Xu Jiarui Chen Xiaoyan Li Diagnosis of infantile subglottic hemangioma: a 10-year experience of 25 cases Frontiers in Pediatrics subglottic hemangioma flexible fiberoptic laryngoscopy contrast-enhanced computed tomography infant diagnosis |
| title | Diagnosis of infantile subglottic hemangioma: a 10-year experience of 25 cases |
| title_full | Diagnosis of infantile subglottic hemangioma: a 10-year experience of 25 cases |
| title_fullStr | Diagnosis of infantile subglottic hemangioma: a 10-year experience of 25 cases |
| title_full_unstemmed | Diagnosis of infantile subglottic hemangioma: a 10-year experience of 25 cases |
| title_short | Diagnosis of infantile subglottic hemangioma: a 10-year experience of 25 cases |
| title_sort | diagnosis of infantile subglottic hemangioma a 10 year experience of 25 cases |
| topic | subglottic hemangioma flexible fiberoptic laryngoscopy contrast-enhanced computed tomography infant diagnosis |
| url | https://www.frontiersin.org/articles/10.3389/fped.2025.1499656/full |
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