Anti-allergic potentials of Ceriops decandra leaves in TDI-induced allergic mice: Comprehensive in-vivo and in-silico studies
Background: Ceriops decandra is a mangrove plant, locally known as “Goran”. This plant has been traditionally used to treat hepatitis, liver disorders, ulcers, diarrhea, gastrointestinal disorders, hemorrhage, pain, inflammation etc. Here we investigated the safety and anti-allergic potential of C....
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| Language: | English |
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Elsevier
2025-02-01
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| Series: | Phytomedicine Plus |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667031324001441 |
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| author | Aishwarja Dey Subarna Rani Rabindra Nath Acharyya Apurba Kumar Barman Khondoker Shahin Ahmed Nripendra Nath Biswas Shrabanti Dev Asish Kumar Das |
| author_facet | Aishwarja Dey Subarna Rani Rabindra Nath Acharyya Apurba Kumar Barman Khondoker Shahin Ahmed Nripendra Nath Biswas Shrabanti Dev Asish Kumar Das |
| author_sort | Aishwarja Dey |
| collection | DOAJ |
| description | Background: Ceriops decandra is a mangrove plant, locally known as “Goran”. This plant has been traditionally used to treat hepatitis, liver disorders, ulcers, diarrhea, gastrointestinal disorders, hemorrhage, pain, inflammation etc. Here we investigated the safety and anti-allergic potential of C. decandra leaves. Method: The toxicity was screened by mortality rate, and behavioral changes in mice. Anti-allergic activity test was conducted on TDI induced allergy model mice by assessing the common allergic symptoms such as sneezing, scratching, nasal score as well as total and differential WBC counts. HPLC-DAD analysis was used to determine the polyphenolic compounds in crude extract and performed in-silico molecular docking against four potential receptor molecules (Histamine H1, Histidine decarboxylate, Interleukin- 4 and 5). Results: The toxicity study of the extract on mice showed the innocuous nature of the plant even at the highest dose of 3000 mg/kg. In the anti-allergic assay, the leaf extract significantly (p < 0.05) decreased the allergic symptoms along with the WBC counts in blood in a dose-dependent manner. The HPLC profile revealed the presence of six phenolic compounds (Catechin hydrate, Caffeic acid, Vanillic acid, Syringic acid, Rutin hydrate, p-coumarin). Among those Rutin hydrate, exhibited the best docking scores at all the targeted protein molecules and the highest binding affinity was (-9.8 kcal/mol) against Interleukin-5. Conclusion: C. decandra is safe and rich in several polyphenolic compounds which are effective against allergic syndromes which could be an effective option for the management of allergic symptoms, although clinical studies are required to establish the herbal formulation. |
| format | Article |
| id | doaj-art-e0fe7876d4ba4d94a9bd0f9e892fcdf4 |
| institution | Kabale University |
| issn | 2667-0313 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Phytomedicine Plus |
| spelling | doaj-art-e0fe7876d4ba4d94a9bd0f9e892fcdf42025-02-10T04:35:04ZengElsevierPhytomedicine Plus2667-03132025-02-0151100670Anti-allergic potentials of Ceriops decandra leaves in TDI-induced allergic mice: Comprehensive in-vivo and in-silico studiesAishwarja Dey0Subarna Rani1Rabindra Nath Acharyya2Apurba Kumar Barman3Khondoker Shahin Ahmed4Nripendra Nath Biswas5Shrabanti Dev6Asish Kumar Das7Pharmacy Discipline, Khulna University, Khulan, 9208, BangladeshPharmacy Discipline, Khulna University, Khulan, 9208, BangladeshPharmacy Discipline, Khulna University, Khulan, 9208, BangladeshDepartment of Pharmacy, R. P. Shaha University, Narayanganj, 1400, BangladeshBangladesh Council of Scientific and Industrial Research (BCSIR), Dhaka, 1205, BangladeshPharmacy Discipline, Khulna University, Khulan, 9208, BangladeshPharmacy Discipline, Khulna University, Khulan, 9208, BangladeshPharmacy Discipline, Khulna University, Khulan, 9208, Bangladesh; Corresponding author at: Khulna University, Bangladesh.Background: Ceriops decandra is a mangrove plant, locally known as “Goran”. This plant has been traditionally used to treat hepatitis, liver disorders, ulcers, diarrhea, gastrointestinal disorders, hemorrhage, pain, inflammation etc. Here we investigated the safety and anti-allergic potential of C. decandra leaves. Method: The toxicity was screened by mortality rate, and behavioral changes in mice. Anti-allergic activity test was conducted on TDI induced allergy model mice by assessing the common allergic symptoms such as sneezing, scratching, nasal score as well as total and differential WBC counts. HPLC-DAD analysis was used to determine the polyphenolic compounds in crude extract and performed in-silico molecular docking against four potential receptor molecules (Histamine H1, Histidine decarboxylate, Interleukin- 4 and 5). Results: The toxicity study of the extract on mice showed the innocuous nature of the plant even at the highest dose of 3000 mg/kg. In the anti-allergic assay, the leaf extract significantly (p < 0.05) decreased the allergic symptoms along with the WBC counts in blood in a dose-dependent manner. The HPLC profile revealed the presence of six phenolic compounds (Catechin hydrate, Caffeic acid, Vanillic acid, Syringic acid, Rutin hydrate, p-coumarin). Among those Rutin hydrate, exhibited the best docking scores at all the targeted protein molecules and the highest binding affinity was (-9.8 kcal/mol) against Interleukin-5. Conclusion: C. decandra is safe and rich in several polyphenolic compounds which are effective against allergic syndromes which could be an effective option for the management of allergic symptoms, although clinical studies are required to establish the herbal formulation.http://www.sciencedirect.com/science/article/pii/S2667031324001441Ceriops decandraAllergyPolyphenolsIn-silico molecular docking |
| spellingShingle | Aishwarja Dey Subarna Rani Rabindra Nath Acharyya Apurba Kumar Barman Khondoker Shahin Ahmed Nripendra Nath Biswas Shrabanti Dev Asish Kumar Das Anti-allergic potentials of Ceriops decandra leaves in TDI-induced allergic mice: Comprehensive in-vivo and in-silico studies Phytomedicine Plus Ceriops decandra Allergy Polyphenols In-silico molecular docking |
| title | Anti-allergic potentials of Ceriops decandra leaves in TDI-induced allergic mice: Comprehensive in-vivo and in-silico studies |
| title_full | Anti-allergic potentials of Ceriops decandra leaves in TDI-induced allergic mice: Comprehensive in-vivo and in-silico studies |
| title_fullStr | Anti-allergic potentials of Ceriops decandra leaves in TDI-induced allergic mice: Comprehensive in-vivo and in-silico studies |
| title_full_unstemmed | Anti-allergic potentials of Ceriops decandra leaves in TDI-induced allergic mice: Comprehensive in-vivo and in-silico studies |
| title_short | Anti-allergic potentials of Ceriops decandra leaves in TDI-induced allergic mice: Comprehensive in-vivo and in-silico studies |
| title_sort | anti allergic potentials of ceriops decandra leaves in tdi induced allergic mice comprehensive in vivo and in silico studies |
| topic | Ceriops decandra Allergy Polyphenols In-silico molecular docking |
| url | http://www.sciencedirect.com/science/article/pii/S2667031324001441 |
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