Dedifferentiated chordoma, a case report
Dedifferentiated chordoma is a rare variant of chordoma, exhibiting simultaneous presence of conventional chordoma and component of high grade sarcoma. It occurs either de novo or in the form of high grade transformation of a conventional chordoma in a setting of recurrence or radiotherapy induced...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Association of Clinical Pathologists of Nepal
2022-03-01
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| Series: | Journal of Pathology of Nepal |
| Subjects: | |
| Online Access: | https://www.nepjol.info/index.php/JPN/article/view/42213 |
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| Summary: | Dedifferentiated chordoma is a rare variant of chordoma, exhibiting simultaneous presence of conventional chordoma and component of high grade sarcoma. It occurs either de novo or in the form of high grade transformation of a conventional chordoma in a setting of recurrence or radiotherapy induced changes. Despite similar clinical manifestations, it shows significantly poorer survival among all variants of chordomas, making an accurate diagnosis important. We, herein, report a case of large chordoma in a 65 years old female, arising de novo in sacrum, where dedifferentiated component was present only focally, highlighting the importance of adequate grossing. |
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| ISSN: | 2091-0797 2091-0908 |