Case report: FGF4L1 retrogene insertion is lacking in the tall dachshund phenotype
Two retrogene insertions, FGF4L1 (formerly 18-FGF4, colloquially CDPA) and FGF4L2 (formerly 12-FGF4, colloquially CDDY), have recently been discovered as determinants of short leg phenotype in dogs. This case study is comprised of a family of standard wirehaired dachshunds in which the dogs lacking...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Veterinary Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2024.1522745/full |
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| author | Stacey Sullivan Katarzyna Julia Szeremeta Michelle Kutzler |
| author_facet | Stacey Sullivan Katarzyna Julia Szeremeta Michelle Kutzler |
| author_sort | Stacey Sullivan |
| collection | DOAJ |
| description | Two retrogene insertions, FGF4L1 (formerly 18-FGF4, colloquially CDPA) and FGF4L2 (formerly 12-FGF4, colloquially CDDY), have recently been discovered as determinants of short leg phenotype in dogs. This case study is comprised of a family of standard wirehaired dachshunds in which the dogs lacking the FGF4L1 gene exhibit a tall phenotype. The tall phenotype in the dachshunds of this report precludes the dog’s working function of den work. The data presented in this report provide information as to how FGF4L1 status could be used in making breeding decisions in dachshunds to maintain working ability without compromising animal health. |
| format | Article |
| id | doaj-art-e0fe081ad106457b927c81b60b73da7a |
| institution | Kabale University |
| issn | 2297-1769 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj-art-e0fe081ad106457b927c81b60b73da7a2025-01-03T06:47:22ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692025-01-011110.3389/fvets.2024.15227451522745Case report: FGF4L1 retrogene insertion is lacking in the tall dachshund phenotypeStacey Sullivan0Katarzyna Julia Szeremeta1Michelle Kutzler2College of Veterinary Medicine, Auburn University, Auburn, AL, United StatesThe International Working Teckel, Mannheim, GermanyDepartment of Animal and Rangeland Sciences, Oregon State University, Corvallis, OR, United StatesTwo retrogene insertions, FGF4L1 (formerly 18-FGF4, colloquially CDPA) and FGF4L2 (formerly 12-FGF4, colloquially CDDY), have recently been discovered as determinants of short leg phenotype in dogs. This case study is comprised of a family of standard wirehaired dachshunds in which the dogs lacking the FGF4L1 gene exhibit a tall phenotype. The tall phenotype in the dachshunds of this report precludes the dog’s working function of den work. The data presented in this report provide information as to how FGF4L1 status could be used in making breeding decisions in dachshunds to maintain working ability without compromising animal health.https://www.frontiersin.org/articles/10.3389/fvets.2024.1522745/fullcase reportCDDYCDPAchondrodystrophychondrodysplasiaFGF4L1 |
| spellingShingle | Stacey Sullivan Katarzyna Julia Szeremeta Michelle Kutzler Case report: FGF4L1 retrogene insertion is lacking in the tall dachshund phenotype Frontiers in Veterinary Science case report CDDY CDPA chondrodystrophy chondrodysplasia FGF4L1 |
| title | Case report: FGF4L1 retrogene insertion is lacking in the tall dachshund phenotype |
| title_full | Case report: FGF4L1 retrogene insertion is lacking in the tall dachshund phenotype |
| title_fullStr | Case report: FGF4L1 retrogene insertion is lacking in the tall dachshund phenotype |
| title_full_unstemmed | Case report: FGF4L1 retrogene insertion is lacking in the tall dachshund phenotype |
| title_short | Case report: FGF4L1 retrogene insertion is lacking in the tall dachshund phenotype |
| title_sort | case report fgf4l1 retrogene insertion is lacking in the tall dachshund phenotype |
| topic | case report CDDY CDPA chondrodystrophy chondrodysplasia FGF4L1 |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2024.1522745/full |
| work_keys_str_mv | AT staceysullivan casereportfgf4l1retrogeneinsertionislackinginthetalldachshundphenotype AT katarzynajuliaszeremeta casereportfgf4l1retrogeneinsertionislackinginthetalldachshundphenotype AT michellekutzler casereportfgf4l1retrogeneinsertionislackinginthetalldachshundphenotype |