Calcium overload via PVT1 reprograms neutrophil fate and constrains gastric cancer progression

Calcium overload via PVT1 reprograms neutrophil fate and constrains gastric cancer progression

Abstract Background The aberrant upregulation of PVT1 in gastric cancer (GC) has emerged as a critical molecular marker, while its mechanism of remodeling the tumor microenvironment (TME) through metabolic regulation remains unclear. This study aims to unveil the novel mechanism by which PVT1 regula...

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Bibliographic Details
Main Authors: Dong Wang, Yunlong Li, Xiaoyu Peng, Lulu Zhang, Ying Zhang, Xue Guan, Xiao Liang, Songbin Fu, Jingcui Yu
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Journal of Translational Medicine
Subjects:
Gastric cancer
PVT1
Tumor-associated neutrophils
Calcium signaling pathway
Replicative senescence
Online Access:https://doi.org/10.1186/s12967-025-06912-6
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