BLASTOCYSTIS HOMINIS INFECTION IN CHILDREN WITH HIV/AIDS DURING COVID-19 RELATED DISRUPTION ERA: A CROSS-SECTIONAL STUDY
Introduction: The coronavirus disease 2019 (COVID-19) epidemic has resulted in significant disruption to health services in multiple nations. In Indonesia, the impact occurred on changes in services for HIV/AIDS patients. As a result, there is a high rate of parasitic co-infection disease, including...
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Universitas Airlangga
2024-11-01
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| Series: | The Indonesian Journal of Public Health |
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| Online Access: | https://e-journal.unair.ac.id/IJPH/article/view/56854 |
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| author | Made Bayu Permasutha Ajib Diptyanusa |
| author_facet | Made Bayu Permasutha Ajib Diptyanusa |
| author_sort | Made Bayu Permasutha |
| collection | DOAJ |
| description | Introduction: The coronavirus disease 2019 (COVID-19) epidemic has resulted in significant disruption to health services in multiple nations. In Indonesia, the impact occurred on changes in services for HIV/AIDS patients. As a result, there is a high rate of parasitic co-infection disease, including Blastocystis hominis. Prior research indicates that the occurrence of this illness varies greatly among individuals with HIV/AIDS, with rates ranging from 3.86% to 72.40%. Aims: The objective of this study is to ascertain the prevalence and molecular epidemiology of infection, develop a predictive model, and examine the correlation between clinical symptoms and the severity of Blastocystis results. Methods: Thirty-eight children with HIV/AIDS in Yogyakarta-Indonesia, from May until August 2021 were examined by direct examination, culture, PCR, and sequencing. In addition, a structured questionnaire was used to obtain additional data regarding baseline information and other factors influencing Blastocystis infection. The results obtained were subjected to phylogenetic, univariate and multivariate data analysis. Results: Out of the 38 samples studied, 26 (68.4%) were positive for Blastocystis. The results of sequencing demonstrated the finding of subtype 3 (ST3) and subtype 4 (ST4). From univariate and multivariate analysis, a longer duration of therapy is a predictor of Blastocystis infection (AOR 6.54, P=0.04). The relationship between clinical manifestations and intensity of Blastocystis findings showed a non-significant association (P>0.99). Conclusion: Children with HIV/AIDS had a significantly high incidence of Blastocystis infection, potentially attributed to the interruption of services resulting from the COVID-19 pandemic. |
| format | Article |
| id | doaj-art-e0fcbc859b474f639fdc50df1765d806 |
| institution | OA Journals |
| issn | 1829-7005 2540-8836 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Universitas Airlangga |
| record_format | Article |
| series | The Indonesian Journal of Public Health |
| spelling | doaj-art-e0fcbc859b474f639fdc50df1765d8062025-08-20T02:26:19ZengUniversitas AirlanggaThe Indonesian Journal of Public Health1829-70052540-88362024-11-0119352053310.20473/ijph.v19i3.2024.520-53355019BLASTOCYSTIS HOMINIS INFECTION IN CHILDREN WITH HIV/AIDS DURING COVID-19 RELATED DISRUPTION ERA: A CROSS-SECTIONAL STUDYMade Bayu Permasutha0https://orcid.org/0000-0003-4788-3114Ajib Diptyanusa1https://orcid.org/0000-0002-1860-0923Parasitology Division, Department of Biomedical Sciences, Faculty of Medicine, Universitas Pendidikan Ganesha, IndonesiaDepartment of Parasitology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, IndonesiaIntroduction: The coronavirus disease 2019 (COVID-19) epidemic has resulted in significant disruption to health services in multiple nations. In Indonesia, the impact occurred on changes in services for HIV/AIDS patients. As a result, there is a high rate of parasitic co-infection disease, including Blastocystis hominis. Prior research indicates that the occurrence of this illness varies greatly among individuals with HIV/AIDS, with rates ranging from 3.86% to 72.40%. Aims: The objective of this study is to ascertain the prevalence and molecular epidemiology of infection, develop a predictive model, and examine the correlation between clinical symptoms and the severity of Blastocystis results. Methods: Thirty-eight children with HIV/AIDS in Yogyakarta-Indonesia, from May until August 2021 were examined by direct examination, culture, PCR, and sequencing. In addition, a structured questionnaire was used to obtain additional data regarding baseline information and other factors influencing Blastocystis infection. The results obtained were subjected to phylogenetic, univariate and multivariate data analysis. Results: Out of the 38 samples studied, 26 (68.4%) were positive for Blastocystis. The results of sequencing demonstrated the finding of subtype 3 (ST3) and subtype 4 (ST4). From univariate and multivariate analysis, a longer duration of therapy is a predictor of Blastocystis infection (AOR 6.54, P=0.04). The relationship between clinical manifestations and intensity of Blastocystis findings showed a non-significant association (P>0.99). Conclusion: Children with HIV/AIDS had a significantly high incidence of Blastocystis infection, potentially attributed to the interruption of services resulting from the COVID-19 pandemic.https://e-journal.unair.ac.id/IJPH/article/view/56854blastocystis hominishiv/aidscovid-19 |
| spellingShingle | Made Bayu Permasutha Ajib Diptyanusa BLASTOCYSTIS HOMINIS INFECTION IN CHILDREN WITH HIV/AIDS DURING COVID-19 RELATED DISRUPTION ERA: A CROSS-SECTIONAL STUDY The Indonesian Journal of Public Health blastocystis hominis hiv/aids covid-19 |
| title | BLASTOCYSTIS HOMINIS INFECTION IN CHILDREN WITH HIV/AIDS DURING COVID-19 RELATED DISRUPTION ERA: A CROSS-SECTIONAL STUDY |
| title_full | BLASTOCYSTIS HOMINIS INFECTION IN CHILDREN WITH HIV/AIDS DURING COVID-19 RELATED DISRUPTION ERA: A CROSS-SECTIONAL STUDY |
| title_fullStr | BLASTOCYSTIS HOMINIS INFECTION IN CHILDREN WITH HIV/AIDS DURING COVID-19 RELATED DISRUPTION ERA: A CROSS-SECTIONAL STUDY |
| title_full_unstemmed | BLASTOCYSTIS HOMINIS INFECTION IN CHILDREN WITH HIV/AIDS DURING COVID-19 RELATED DISRUPTION ERA: A CROSS-SECTIONAL STUDY |
| title_short | BLASTOCYSTIS HOMINIS INFECTION IN CHILDREN WITH HIV/AIDS DURING COVID-19 RELATED DISRUPTION ERA: A CROSS-SECTIONAL STUDY |
| title_sort | blastocystis hominis infection in children with hiv aids during covid 19 related disruption era a cross sectional study |
| topic | blastocystis hominis hiv/aids covid-19 |
| url | https://e-journal.unair.ac.id/IJPH/article/view/56854 |
| work_keys_str_mv | AT madebayupermasutha blastocystishominisinfectioninchildrenwithhivaidsduringcovid19relateddisruptioneraacrosssectionalstudy AT ajibdiptyanusa blastocystishominisinfectioninchildrenwithhivaidsduringcovid19relateddisruptioneraacrosssectionalstudy |