The Emerging World of JAK Inhibitors
The Janus Kinase inhibitors are a new emerging class of small molecules. These target the Janus Kinase proteins located on the cell membrane. Janus Kinase proteins regulate the cellular transcription of several proteins and act as mediators in several cytokine pathways. Dysregulation in these cytok...
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| Format: | Article |
| Language: | English |
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Society of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON)
2024-10-01
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| Series: | Nepal Journal of Dermatology, Venereology & Leprology |
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| Online Access: | https://www.nepjol.info/index.php/NJDVL/article/view/68527 |
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| _version_ | 1849227538613665792 |
|---|---|
| author | Shraddha Uprety |
| author_facet | Shraddha Uprety |
| author_sort | Shraddha Uprety |
| collection | DOAJ |
| description |
The Janus Kinase inhibitors are a new emerging class of small molecules. These target the Janus Kinase proteins located on the cell membrane. Janus Kinase proteins regulate the cellular transcription of several proteins and act as mediators in several cytokine pathways. Dysregulation in these cytokine pathways is responsible for disorders like alopecia areata, psoriasis, vitiligo, lichen planus, and more in dermatology. Contrary to the injectable biologics, these Janus kinase inhibitors can be taken per oral route and have greater patient acceptability. In this review, we seek to discuss the various indications of Janus Kinase inhibitors and their side effects. We also strive to discuss the monitoring for this class of drugs.
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| format | Article |
| id | doaj-art-e0fc90c6b6ea45ba8719fe006f246317 |
| institution | Kabale University |
| issn | 2091-0231 2091-167X |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Society of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON) |
| record_format | Article |
| series | Nepal Journal of Dermatology, Venereology & Leprology |
| spelling | doaj-art-e0fc90c6b6ea45ba8719fe006f2463172025-08-23T10:03:30ZengSociety of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON)Nepal Journal of Dermatology, Venereology & Leprology2091-02312091-167X2024-10-0122210.3126/njdvl.v22i2.68527The Emerging World of JAK InhibitorsShraddha Uprety0Chitwan Medical College and Teaching Hospital The Janus Kinase inhibitors are a new emerging class of small molecules. These target the Janus Kinase proteins located on the cell membrane. Janus Kinase proteins regulate the cellular transcription of several proteins and act as mediators in several cytokine pathways. Dysregulation in these cytokine pathways is responsible for disorders like alopecia areata, psoriasis, vitiligo, lichen planus, and more in dermatology. Contrary to the injectable biologics, these Janus kinase inhibitors can be taken per oral route and have greater patient acceptability. In this review, we seek to discuss the various indications of Janus Kinase inhibitors and their side effects. We also strive to discuss the monitoring for this class of drugs. https://www.nepjol.info/index.php/NJDVL/article/view/68527Alopecia areataAtopic DermatitisJAK inhibitorsLichen PlanusPruritusPsoriasis |
| spellingShingle | Shraddha Uprety The Emerging World of JAK Inhibitors Nepal Journal of Dermatology, Venereology & Leprology Alopecia areata Atopic Dermatitis JAK inhibitors Lichen Planus Pruritus Psoriasis |
| title | The Emerging World of JAK Inhibitors |
| title_full | The Emerging World of JAK Inhibitors |
| title_fullStr | The Emerging World of JAK Inhibitors |
| title_full_unstemmed | The Emerging World of JAK Inhibitors |
| title_short | The Emerging World of JAK Inhibitors |
| title_sort | emerging world of jak inhibitors |
| topic | Alopecia areata Atopic Dermatitis JAK inhibitors Lichen Planus Pruritus Psoriasis |
| url | https://www.nepjol.info/index.php/NJDVL/article/view/68527 |
| work_keys_str_mv | AT shraddhauprety theemergingworldofjakinhibitors AT shraddhauprety emergingworldofjakinhibitors |