MORPHOFUNCTIONAL FEATURES OF THE PLACENTA OF NEWBORNS IN BIRTH-INDUCED CRITICAL CONDITIONS: THE RESULTS OF A RETROSPECTIVE COHORT STUDY
Background. The placenta condition is the health marker of newborns and it can be considered in the early diagnosis of the development of severe pathological conditions in a child. Objective: Our aim was to study the relationship between the placenta characteristics and the risk of a birth-indu...
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Union of pediatricians of Russia
2017-08-01
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| Series: | Педиатрическая фармакология |
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| Online Access: | https://www.pedpharma.ru/jour/article/view/1520 |
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| author | Olga A. Senkevich Klaudia E. Popova Olga V. Kozharskaia Denis V. Musatov |
| author_facet | Olga A. Senkevich Klaudia E. Popova Olga V. Kozharskaia Denis V. Musatov |
| author_sort | Olga A. Senkevich |
| collection | DOAJ |
| description | Background. The placenta condition is the health marker of newborns and it can be considered in the early diagnosis of the development of severe pathological conditions in a child. Objective: Our aim was to study the relationship between the placenta characteristics and the risk of a birth-induced critical condition in a child and the risk of having children with the APGAR score of < 4 points.Methods. The data of macro- and microscopic studies of the placenta of newborns who have experienced birth-induced critical conditions was retrospectively analyzed. Birth-induced critical conditions were the APGAR score at 1 min after birth < 4 points and/or the presence of severe perinatal hypoxia, cerebral ischemia requiring respiratory support and intensive care in the intensive care unit.Results. We examined 92 placentas of mothers who gave birth to children in a critical condition. Depending on the APGAR score at 1 min after birth, the main group (n = 56, < 4 points) and the comparison group (n = 36, > 4 points) were singled out. In multivariate analysis, it was established that the appearance of a birth-induced critical condition with the APGAR score < 4 points was associated with pathological attachment of the umbilical cord (odds ratio, OR, 2.8, 95% confidence interval, CI, 1.1–7.0), placenta weight (OR 5.4, 95% CI 1.9–14.9), signs of chronic fetoplacental insufficiency (OR 7.3, 95% CI 2.9–18.8), impaired blood circulation in the placenta (OR 13.7, 95% CI 4.7–39.3), placental hypoplasia (OR 8.9, 95% CI 2.4–32.4), fetal-placental ratio (OR 8.9, 95% CI 2.4–32.4) as well as low birth weight of a newborn (OR 2.9, 95% CI 1.2–6.9). Conclusion. Morphological characteristics of the placenta are prognostic markers for the development of critical conditions with the APGAR score at birth < 4 points. |
| format | Article |
| id | doaj-art-e0fa2eba25944313b02aa8d712ede51e |
| institution | DOAJ |
| issn | 1727-5776 2500-3089 |
| language | Russian |
| publishDate | 2017-08-01 |
| publisher | Union of pediatricians of Russia |
| record_format | Article |
| series | Педиатрическая фармакология |
| spelling | doaj-art-e0fa2eba25944313b02aa8d712ede51e2025-08-20T03:19:39ZrusUnion of pediatricians of RussiaПедиатрическая фармакология1727-57762500-30892017-08-0114317918510.15690/pf.v14i3.17421492MORPHOFUNCTIONAL FEATURES OF THE PLACENTA OF NEWBORNS IN BIRTH-INDUCED CRITICAL CONDITIONS: THE RESULTS OF A RETROSPECTIVE COHORT STUDYOlga A. Senkevich0Klaudia E. Popova1Olga V. Kozharskaia2Denis V. Musatov3Far Eastern State Medical UniversityFar Eastern State Medical UniversityPerinatal CenterPerinatal CenterBackground. The placenta condition is the health marker of newborns and it can be considered in the early diagnosis of the development of severe pathological conditions in a child. Objective: Our aim was to study the relationship between the placenta characteristics and the risk of a birth-induced critical condition in a child and the risk of having children with the APGAR score of < 4 points.Methods. The data of macro- and microscopic studies of the placenta of newborns who have experienced birth-induced critical conditions was retrospectively analyzed. Birth-induced critical conditions were the APGAR score at 1 min after birth < 4 points and/or the presence of severe perinatal hypoxia, cerebral ischemia requiring respiratory support and intensive care in the intensive care unit.Results. We examined 92 placentas of mothers who gave birth to children in a critical condition. Depending on the APGAR score at 1 min after birth, the main group (n = 56, < 4 points) and the comparison group (n = 36, > 4 points) were singled out. In multivariate analysis, it was established that the appearance of a birth-induced critical condition with the APGAR score < 4 points was associated with pathological attachment of the umbilical cord (odds ratio, OR, 2.8, 95% confidence interval, CI, 1.1–7.0), placenta weight (OR 5.4, 95% CI 1.9–14.9), signs of chronic fetoplacental insufficiency (OR 7.3, 95% CI 2.9–18.8), impaired blood circulation in the placenta (OR 13.7, 95% CI 4.7–39.3), placental hypoplasia (OR 8.9, 95% CI 2.4–32.4), fetal-placental ratio (OR 8.9, 95% CI 2.4–32.4) as well as low birth weight of a newborn (OR 2.9, 95% CI 1.2–6.9). Conclusion. Morphological characteristics of the placenta are prognostic markers for the development of critical conditions with the APGAR score at birth < 4 points.https://www.pedpharma.ru/jour/article/view/1520newbornscritical conditionsplacentaplacental insufficiencyrisk factors |
| spellingShingle | Olga A. Senkevich Klaudia E. Popova Olga V. Kozharskaia Denis V. Musatov MORPHOFUNCTIONAL FEATURES OF THE PLACENTA OF NEWBORNS IN BIRTH-INDUCED CRITICAL CONDITIONS: THE RESULTS OF A RETROSPECTIVE COHORT STUDY Педиатрическая фармакология newborns critical conditions placenta placental insufficiency risk factors |
| title | MORPHOFUNCTIONAL FEATURES OF THE PLACENTA OF NEWBORNS IN BIRTH-INDUCED CRITICAL CONDITIONS: THE RESULTS OF A RETROSPECTIVE COHORT STUDY |
| title_full | MORPHOFUNCTIONAL FEATURES OF THE PLACENTA OF NEWBORNS IN BIRTH-INDUCED CRITICAL CONDITIONS: THE RESULTS OF A RETROSPECTIVE COHORT STUDY |
| title_fullStr | MORPHOFUNCTIONAL FEATURES OF THE PLACENTA OF NEWBORNS IN BIRTH-INDUCED CRITICAL CONDITIONS: THE RESULTS OF A RETROSPECTIVE COHORT STUDY |
| title_full_unstemmed | MORPHOFUNCTIONAL FEATURES OF THE PLACENTA OF NEWBORNS IN BIRTH-INDUCED CRITICAL CONDITIONS: THE RESULTS OF A RETROSPECTIVE COHORT STUDY |
| title_short | MORPHOFUNCTIONAL FEATURES OF THE PLACENTA OF NEWBORNS IN BIRTH-INDUCED CRITICAL CONDITIONS: THE RESULTS OF A RETROSPECTIVE COHORT STUDY |
| title_sort | morphofunctional features of the placenta of newborns in birth induced critical conditions the results of a retrospective cohort study |
| topic | newborns critical conditions placenta placental insufficiency risk factors |
| url | https://www.pedpharma.ru/jour/article/view/1520 |
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