Association of systemic immune-inflammation index (SII) with epigenetic age acceleration in adults: insights from NHANES
The Systemic Immune-Inflammation Index (SII), a marker of systemic inflammation, has been linked to various age-related diseases, but its association with Epigenetic Age Acceleration (EAA) remains underexplored. This study aimed to investigate the SII and EAA relationship. We analysed data from 1,91...
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Taylor & Francis Group
2025-12-01
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| Series: | Epigenetics |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/15592294.2025.2541248 |
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| author | Rundong Liu Mingjie Liu Chendong Wang Zhen Tao Guangyuan Hu |
| author_facet | Rundong Liu Mingjie Liu Chendong Wang Zhen Tao Guangyuan Hu |
| author_sort | Rundong Liu |
| collection | DOAJ |
| description | The Systemic Immune-Inflammation Index (SII), a marker of systemic inflammation, has been linked to various age-related diseases, but its association with Epigenetic Age Acceleration (EAA) remains underexplored. This study aimed to investigate the SII and EAA relationship. We analysed data from 1,915 participants from the National Health and Nutrition Examination Survey (NHANES). SII was calculated as platelet count × (neutrophil count/lymphocyte count). EAA was defined as HorvathAccel, HannumAccel, Skin&BloodAccel, PhenoAgeAccel, GrimAge2Accel, and DunedinPoAm. These metrics were derived utilizing the residual method. Multivariate linear regression, smooth curve fitting, threshold effect analyses, and subgroup analyses were employed to assess the relationship between the SII and EAA. Higher SII levels were significantly associated with HannumAccel, PhenoAgeAccel, GrimAge2Accel, and DunedinPoAm. Threshold effect analyses revealed non-linear relationships, with inflection points at SII values of 24.200, 12.553, 7.766, and 10.133, respectively. Subgroup analyses identified sex, age, poverty-to-income ratio, and marital status as significant effect modifiers. The elevated SII was associated with accelerated epigenetic ageing. |
| format | Article |
| id | doaj-art-e0f8217c51ff49d49390f8749fb024a0 |
| institution | Kabale University |
| issn | 1559-2294 1559-2308 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Epigenetics |
| spelling | doaj-art-e0f8217c51ff49d49390f8749fb024a02025-08-20T03:59:30ZengTaylor & Francis GroupEpigenetics1559-22941559-23082025-12-0120110.1080/15592294.2025.2541248Association of systemic immune-inflammation index (SII) with epigenetic age acceleration in adults: insights from NHANESRundong Liu0Mingjie Liu1Chendong Wang2Zhen Tao3Guangyuan Hu4Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, P.R. ChinaDepartment of Oncology, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, P.R. ChinaHepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, P.R. ChinaDepartment of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, P.R. ChinaDepartment of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, P.R. ChinaThe Systemic Immune-Inflammation Index (SII), a marker of systemic inflammation, has been linked to various age-related diseases, but its association with Epigenetic Age Acceleration (EAA) remains underexplored. This study aimed to investigate the SII and EAA relationship. We analysed data from 1,915 participants from the National Health and Nutrition Examination Survey (NHANES). SII was calculated as platelet count × (neutrophil count/lymphocyte count). EAA was defined as HorvathAccel, HannumAccel, Skin&BloodAccel, PhenoAgeAccel, GrimAge2Accel, and DunedinPoAm. These metrics were derived utilizing the residual method. Multivariate linear regression, smooth curve fitting, threshold effect analyses, and subgroup analyses were employed to assess the relationship between the SII and EAA. Higher SII levels were significantly associated with HannumAccel, PhenoAgeAccel, GrimAge2Accel, and DunedinPoAm. Threshold effect analyses revealed non-linear relationships, with inflection points at SII values of 24.200, 12.553, 7.766, and 10.133, respectively. Subgroup analyses identified sex, age, poverty-to-income ratio, and marital status as significant effect modifiers. The elevated SII was associated with accelerated epigenetic ageing.https://www.tandfonline.com/doi/10.1080/15592294.2025.2541248Systemic immune-inflammation index (SII)epigenetic age acceleration (EAA)NHANESbiological agingDNA methylation |
| spellingShingle | Rundong Liu Mingjie Liu Chendong Wang Zhen Tao Guangyuan Hu Association of systemic immune-inflammation index (SII) with epigenetic age acceleration in adults: insights from NHANES Epigenetics Systemic immune-inflammation index (SII) epigenetic age acceleration (EAA) NHANES biological aging DNA methylation |
| title | Association of systemic immune-inflammation index (SII) with epigenetic age acceleration in adults: insights from NHANES |
| title_full | Association of systemic immune-inflammation index (SII) with epigenetic age acceleration in adults: insights from NHANES |
| title_fullStr | Association of systemic immune-inflammation index (SII) with epigenetic age acceleration in adults: insights from NHANES |
| title_full_unstemmed | Association of systemic immune-inflammation index (SII) with epigenetic age acceleration in adults: insights from NHANES |
| title_short | Association of systemic immune-inflammation index (SII) with epigenetic age acceleration in adults: insights from NHANES |
| title_sort | association of systemic immune inflammation index sii with epigenetic age acceleration in adults insights from nhanes |
| topic | Systemic immune-inflammation index (SII) epigenetic age acceleration (EAA) NHANES biological aging DNA methylation |
| url | https://www.tandfonline.com/doi/10.1080/15592294.2025.2541248 |
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