Polymer-Free Electrospinning of β-Cyclodextrin–Oligolactide for Magnolol and Honokiol Pharmaceutical Formulations
<b>Background:</b> Magnolol (MG) and honokiol (HK) are bioactive compounds extracted from <i>Magnolia obovata</i> and <i>Magnolia Officinalis</i> trees with significant pharmacological properties, including antioxidant and antibacterial activity. However, their po...
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2025-01-01
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| Online Access: | https://www.mdpi.com/1999-4923/17/1/130 |
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| author | Diana-Andreea Blaj Catalina A. Peptu Mihaela Balan-Porcarasu Cristian Peptu Cristina Gabriela Tuchilus Lacramioara Ochiuz |
| author_facet | Diana-Andreea Blaj Catalina A. Peptu Mihaela Balan-Porcarasu Cristian Peptu Cristina Gabriela Tuchilus Lacramioara Ochiuz |
| author_sort | Diana-Andreea Blaj |
| collection | DOAJ |
| description | <b>Background:</b> Magnolol (MG) and honokiol (HK) are bioactive compounds extracted from <i>Magnolia obovata</i> and <i>Magnolia Officinalis</i> trees with significant pharmacological properties, including antioxidant and antibacterial activity. However, their poor water solubility and low bioavailability limit the therapeutic potential. <b>Methods:</b> To address these limitations, this study aims to develop MG and HK formulations by co-electrospinning using custom-synthesized β-cyclodextrin–oligolactide (β-CDLA) derivatives. MALDI MS and NMR were employed for the structural assessment of the β-CDLA derivatives. This polymer-free electrospinning technique utilizes the high solubility of β-CDLA to incorporate MG and HK into fibrous webs. The morphology of the resulting fibers is established by SEM and further characterized using FTIR and NMR spectroscopy to confirm the successful incorporation of MG and HK. The antioxidant activity was determined using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay, while the antimicrobial activity was evaluated against several standard microorganisms (<i>Staphylococcus aureus</i>, <i>Escherichia coli</i>, <i>Pseudomonas aeruginosa</i>, and <i>Candida albicans</i>). <b>Results:</b> The MG and HK electrospun formulations were prepared using highly concentrated feed solutions in dimethylformamide (180% w/v). The resulting β-CDLA fibers, with diameters above 400 nm and an active compound content of 7% wt., exhibited enhanced long-term antioxidant activity and improved antimicrobial efficacy, including notable activity against <i>Escherichia coli</i>. <b>Conclusions:</b> This study demonstrates the potential of MG and HK-loaded β-CDLA fibrous formulations as delivery systems with prolonged antioxidant activity and notable antibacterial efficacy, providing a promising platform for biomedical applications. |
| format | Article |
| id | doaj-art-e0f48ab6c16f472c9a799c037e91283a |
| institution | Kabale University |
| issn | 1999-4923 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj-art-e0f48ab6c16f472c9a799c037e91283a2025-01-24T13:46:05ZengMDPI AGPharmaceutics1999-49232025-01-0117113010.3390/pharmaceutics17010130Polymer-Free Electrospinning of β-Cyclodextrin–Oligolactide for Magnolol and Honokiol Pharmaceutical FormulationsDiana-Andreea Blaj0Catalina A. Peptu1Mihaela Balan-Porcarasu2Cristian Peptu3Cristina Gabriela Tuchilus4Lacramioara Ochiuz5“Petru Poni” Institute of Macromolecular Chemistry, 700487 Iasi, RomaniaFaculty of Chemical Engineering and Protection of the Environment, “Gheorghe Asachi” Technical University of Iasi, 700050 Iasi, Romania“Petru Poni” Institute of Macromolecular Chemistry, 700487 Iasi, Romania“Petru Poni” Institute of Macromolecular Chemistry, 700487 Iasi, RomaniaFaculty of Medicine, “Grigore. T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaFaculty of Pharmacy, “Grigore. T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania<b>Background:</b> Magnolol (MG) and honokiol (HK) are bioactive compounds extracted from <i>Magnolia obovata</i> and <i>Magnolia Officinalis</i> trees with significant pharmacological properties, including antioxidant and antibacterial activity. However, their poor water solubility and low bioavailability limit the therapeutic potential. <b>Methods:</b> To address these limitations, this study aims to develop MG and HK formulations by co-electrospinning using custom-synthesized β-cyclodextrin–oligolactide (β-CDLA) derivatives. MALDI MS and NMR were employed for the structural assessment of the β-CDLA derivatives. This polymer-free electrospinning technique utilizes the high solubility of β-CDLA to incorporate MG and HK into fibrous webs. The morphology of the resulting fibers is established by SEM and further characterized using FTIR and NMR spectroscopy to confirm the successful incorporation of MG and HK. The antioxidant activity was determined using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay, while the antimicrobial activity was evaluated against several standard microorganisms (<i>Staphylococcus aureus</i>, <i>Escherichia coli</i>, <i>Pseudomonas aeruginosa</i>, and <i>Candida albicans</i>). <b>Results:</b> The MG and HK electrospun formulations were prepared using highly concentrated feed solutions in dimethylformamide (180% w/v). The resulting β-CDLA fibers, with diameters above 400 nm and an active compound content of 7% wt., exhibited enhanced long-term antioxidant activity and improved antimicrobial efficacy, including notable activity against <i>Escherichia coli</i>. <b>Conclusions:</b> This study demonstrates the potential of MG and HK-loaded β-CDLA fibrous formulations as delivery systems with prolonged antioxidant activity and notable antibacterial efficacy, providing a promising platform for biomedical applications.https://www.mdpi.com/1999-4923/17/1/130magnololhonokiolcyclodextrin–oligolactideelectrospinningnanofibersantioxidant activity |
| spellingShingle | Diana-Andreea Blaj Catalina A. Peptu Mihaela Balan-Porcarasu Cristian Peptu Cristina Gabriela Tuchilus Lacramioara Ochiuz Polymer-Free Electrospinning of β-Cyclodextrin–Oligolactide for Magnolol and Honokiol Pharmaceutical Formulations Pharmaceutics magnolol honokiol cyclodextrin–oligolactide electrospinning nanofibers antioxidant activity |
| title | Polymer-Free Electrospinning of β-Cyclodextrin–Oligolactide for Magnolol and Honokiol Pharmaceutical Formulations |
| title_full | Polymer-Free Electrospinning of β-Cyclodextrin–Oligolactide for Magnolol and Honokiol Pharmaceutical Formulations |
| title_fullStr | Polymer-Free Electrospinning of β-Cyclodextrin–Oligolactide for Magnolol and Honokiol Pharmaceutical Formulations |
| title_full_unstemmed | Polymer-Free Electrospinning of β-Cyclodextrin–Oligolactide for Magnolol and Honokiol Pharmaceutical Formulations |
| title_short | Polymer-Free Electrospinning of β-Cyclodextrin–Oligolactide for Magnolol and Honokiol Pharmaceutical Formulations |
| title_sort | polymer free electrospinning of β cyclodextrin oligolactide for magnolol and honokiol pharmaceutical formulations |
| topic | magnolol honokiol cyclodextrin–oligolactide electrospinning nanofibers antioxidant activity |
| url | https://www.mdpi.com/1999-4923/17/1/130 |
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