15-Lipoxygenase-2 deficiency induces foam cell formation that can be restored by salidroside through the inhibition of arachidonic acid effects

15-Lipoxygenase-2 deficiency induces foam cell formation that can be restored by salidroside through the inhibition of arachidonic acid effects

15-Lipoxygenase-2 (15-Lox-2) is one of the key enzymes in arachidonic acid (AA) metabolic pathway, which belongs to the unsaturated fatty acid metabolic pathway. This pathway is involved in the foam cell transformation of macrophages during the progression of atherosclerosis (AS). The role of salidr...

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Bibliographic Details
Main Authors: Huang Rong, Yong Xi, Li Tingting, Wen Huling, Zhou Xing, Liao Yichen, You Jun, Yu Chunlei, Xu Peng, Wang Yuquan, Wen Dan, Xia Tianqin, Yang Hao, Chen Yanqin, Xu Lei, Zhong Xiaorong, Li Xianfu, Xu Zhengmin, Zhou Chunyang
Format: Article
Language:English
Published: De Gruyter 2025-04-01
Series:Open Life Sciences
Subjects:
15-lipoxygenase-2
foam cell formation
macrophages
arachidonic acid
salidroside
Online Access:https://doi.org/10.1515/biol-2025-1091
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