Associative memory cells of encoding fear signals and anxiety are recruited by neuroligin-3-mediated synapse formation
Abstract Acute severe stress may induce fear memory and anxiety. Their mechanisms are expectedly revealed to explore therapeutic strategies. We have investigated the recruitment of associative memory cells that encode stress signals to cause fear memory and anxiety by multidisciplinary approaches. I...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-11-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-024-07170-w |
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| author | Bingchen Chen Yun Zhang Huajuan Xiao Lei Wang Jiayi Li Yang Xu Jin-Hui Wang |
| author_facet | Bingchen Chen Yun Zhang Huajuan Xiao Lei Wang Jiayi Li Yang Xu Jin-Hui Wang |
| author_sort | Bingchen Chen |
| collection | DOAJ |
| description | Abstract Acute severe stress may induce fear memory and anxiety. Their mechanisms are expectedly revealed to explore therapeutic strategies. We have investigated the recruitment of associative memory cells that encode stress signals to cause fear memory and anxiety by multidisciplinary approaches. In addition to fear memory and anxiety, the social stress by the resident/intruder paradigm leads to synapse interconnections between somatosensory S1-Tr and auditory cortical neurons in intruder mice. These S1-Tr cortical neurons become to receive convergent synapse innervations newly from the auditory cortex and innately from the thalamus as well as encode the stress signals including battle sound and somatic pain, i.e., associative memory neurons. Neuroligin-3 mRNA knockdown in the S1-Tr cortex precludes the recruitment of associative memory neurons and the onset of fear memory and anxiety. The stress-induced recruitment of associative memory cells in sensory cortices for stress-relevant fear memory and anxiety is based on neuroligin-3-mediated new synapse formation. |
| format | Article |
| id | doaj-art-e0e7d5172a1c4f09b74f5ace0e440de2 |
| institution | Kabale University |
| issn | 2399-3642 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj-art-e0e7d5172a1c4f09b74f5ace0e440de22024-11-10T12:39:16ZengNature PortfolioCommunications Biology2399-36422024-11-017111910.1038/s42003-024-07170-wAssociative memory cells of encoding fear signals and anxiety are recruited by neuroligin-3-mediated synapse formationBingchen Chen0Yun Zhang1Huajuan Xiao2Lei Wang3Jiayi Li4Yang Xu5Jin-Hui Wang6College of Life Science, University of Chinese Academy of SciencesCollege of Life Science, University of Chinese Academy of SciencesCollege of Life Science, University of Chinese Academy of SciencesCollege of Life Science, University of Chinese Academy of SciencesCollege of Life Science, University of Chinese Academy of SciencesCollege of Life Science, University of Chinese Academy of SciencesCollege of Life Science, University of Chinese Academy of SciencesAbstract Acute severe stress may induce fear memory and anxiety. Their mechanisms are expectedly revealed to explore therapeutic strategies. We have investigated the recruitment of associative memory cells that encode stress signals to cause fear memory and anxiety by multidisciplinary approaches. In addition to fear memory and anxiety, the social stress by the resident/intruder paradigm leads to synapse interconnections between somatosensory S1-Tr and auditory cortical neurons in intruder mice. These S1-Tr cortical neurons become to receive convergent synapse innervations newly from the auditory cortex and innately from the thalamus as well as encode the stress signals including battle sound and somatic pain, i.e., associative memory neurons. Neuroligin-3 mRNA knockdown in the S1-Tr cortex precludes the recruitment of associative memory neurons and the onset of fear memory and anxiety. The stress-induced recruitment of associative memory cells in sensory cortices for stress-relevant fear memory and anxiety is based on neuroligin-3-mediated new synapse formation.https://doi.org/10.1038/s42003-024-07170-w |
| spellingShingle | Bingchen Chen Yun Zhang Huajuan Xiao Lei Wang Jiayi Li Yang Xu Jin-Hui Wang Associative memory cells of encoding fear signals and anxiety are recruited by neuroligin-3-mediated synapse formation Communications Biology |
| title | Associative memory cells of encoding fear signals and anxiety are recruited by neuroligin-3-mediated synapse formation |
| title_full | Associative memory cells of encoding fear signals and anxiety are recruited by neuroligin-3-mediated synapse formation |
| title_fullStr | Associative memory cells of encoding fear signals and anxiety are recruited by neuroligin-3-mediated synapse formation |
| title_full_unstemmed | Associative memory cells of encoding fear signals and anxiety are recruited by neuroligin-3-mediated synapse formation |
| title_short | Associative memory cells of encoding fear signals and anxiety are recruited by neuroligin-3-mediated synapse formation |
| title_sort | associative memory cells of encoding fear signals and anxiety are recruited by neuroligin 3 mediated synapse formation |
| url | https://doi.org/10.1038/s42003-024-07170-w |
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