Insecticidal potential of five medicinal plants: An In Vitro evaluation and molecular docking analysis of Artemisia absinthium.
The Kashmir range of North-Western Himalayas harbours a large number of medicinal plants that have insecticidal, antifeedent or insect repellent properties. Herein, we evaluated the insecticidal activity of five medicinal plants including Artemisia absinthium, Acorus calamus, Digitalis purpurea, Ple...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2025-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0325959 |
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| author | Mohd Yaseen Mudasir Gani Shabir Ahmad Ganai Baseerat Ul Ann Fehim Jeelani Wani Mohd Ayoub Mantoo Khalid Rasool Rashid Mumtaz Khan |
| author_facet | Mohd Yaseen Mudasir Gani Shabir Ahmad Ganai Baseerat Ul Ann Fehim Jeelani Wani Mohd Ayoub Mantoo Khalid Rasool Rashid Mumtaz Khan |
| author_sort | Mohd Yaseen |
| collection | DOAJ |
| description | The Kashmir range of North-Western Himalayas harbours a large number of medicinal plants that have insecticidal, antifeedent or insect repellent properties. Herein, we evaluated the insecticidal activity of five medicinal plants including Artemisia absinthium, Acorus calamus, Digitalis purpurea, Plectranthus rugosus and Achiella millefolium against Corcyra cephalonica, Sitophilus oryzae and Helicoverpa armigera. The highest in vitro insecticidal activity was observed with the A. absinthium plant extract against the test insects. Following this, A. absinthium extract was assessed through high resolution liquid chromatography mass spectrometry (HR-LCMS). The small molecules thus identified from the A. absinthium extract were flexibly docked against the active site of acetylcholinesterase (Helicoverpa armigera) keeping the known inhibitor malaoxon as the reference. Four molecules encompassing kaempferol, diosmetin, 1,7-Bis(4-hydroxyphenyl) heptan-3-one and NP-021018 explored from the defined extract manifested the highest binding affinity than malaoxon. As kaempferol evinced the maximum binding activity towards acetylcholinesterase thus, the insecticidal activity of A. absinthium extract may be attributed to this molecule. |
| format | Article |
| id | doaj-art-e0e69a5d00b14ec3872fee42e8c71026 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-e0e69a5d00b14ec3872fee42e8c710262025-08-20T03:50:26ZengPublic Library of Science (PLoS)PLoS ONE1932-62032025-01-01207e032595910.1371/journal.pone.0325959Insecticidal potential of five medicinal plants: An In Vitro evaluation and molecular docking analysis of Artemisia absinthium.Mohd YaseenMudasir GaniShabir Ahmad GanaiBaseerat Ul AnnFehim Jeelani WaniMohd Ayoub MantooKhalid RasoolRashid Mumtaz KhanThe Kashmir range of North-Western Himalayas harbours a large number of medicinal plants that have insecticidal, antifeedent or insect repellent properties. Herein, we evaluated the insecticidal activity of five medicinal plants including Artemisia absinthium, Acorus calamus, Digitalis purpurea, Plectranthus rugosus and Achiella millefolium against Corcyra cephalonica, Sitophilus oryzae and Helicoverpa armigera. The highest in vitro insecticidal activity was observed with the A. absinthium plant extract against the test insects. Following this, A. absinthium extract was assessed through high resolution liquid chromatography mass spectrometry (HR-LCMS). The small molecules thus identified from the A. absinthium extract were flexibly docked against the active site of acetylcholinesterase (Helicoverpa armigera) keeping the known inhibitor malaoxon as the reference. Four molecules encompassing kaempferol, diosmetin, 1,7-Bis(4-hydroxyphenyl) heptan-3-one and NP-021018 explored from the defined extract manifested the highest binding affinity than malaoxon. As kaempferol evinced the maximum binding activity towards acetylcholinesterase thus, the insecticidal activity of A. absinthium extract may be attributed to this molecule.https://doi.org/10.1371/journal.pone.0325959 |
| spellingShingle | Mohd Yaseen Mudasir Gani Shabir Ahmad Ganai Baseerat Ul Ann Fehim Jeelani Wani Mohd Ayoub Mantoo Khalid Rasool Rashid Mumtaz Khan Insecticidal potential of five medicinal plants: An In Vitro evaluation and molecular docking analysis of Artemisia absinthium. PLoS ONE |
| title | Insecticidal potential of five medicinal plants: An In Vitro evaluation and molecular docking analysis of Artemisia absinthium. |
| title_full | Insecticidal potential of five medicinal plants: An In Vitro evaluation and molecular docking analysis of Artemisia absinthium. |
| title_fullStr | Insecticidal potential of five medicinal plants: An In Vitro evaluation and molecular docking analysis of Artemisia absinthium. |
| title_full_unstemmed | Insecticidal potential of five medicinal plants: An In Vitro evaluation and molecular docking analysis of Artemisia absinthium. |
| title_short | Insecticidal potential of five medicinal plants: An In Vitro evaluation and molecular docking analysis of Artemisia absinthium. |
| title_sort | insecticidal potential of five medicinal plants an in vitro evaluation and molecular docking analysis of artemisia absinthium |
| url | https://doi.org/10.1371/journal.pone.0325959 |
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