Performance of Clinical Criteria for Screening of Possible Antiretroviral Related Mitochondrial Toxicity in HIV-Infected Children in Accra
Mitochondrial damage is implicated in highly active antiretroviral therapy (HAART) toxicity. HIV infection also causes mitochondrial toxicity (MT). Differentiating between the two is critical for HIV management. Our objective was to test the utility of the Mitochondrial Disease Criteria (MDC) and th...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | AIDS Research and Treatment |
| Online Access: | http://dx.doi.org/10.1155/2013/249171 |
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| _version_ | 1849467920452681728 |
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| author | Allison Langs-Barlow Lorna Renner Karol Katz Veronika Northrup Elijah Paintsil |
| author_facet | Allison Langs-Barlow Lorna Renner Karol Katz Veronika Northrup Elijah Paintsil |
| author_sort | Allison Langs-Barlow |
| collection | DOAJ |
| description | Mitochondrial damage is implicated in highly active antiretroviral therapy (HAART) toxicity. HIV infection also causes mitochondrial toxicity (MT). Differentiating between the two is critical for HIV management. Our objective was to test the utility of the Mitochondrial Disease Criteria (MDC) and the Enquête Périnatale Française (EPF) to screen for possible HAART related MT in HIV-infected children in Ghana. The EPF and MDC are compilations of clinical symptoms, or criteria, of MT: a (+) score indicates possible MT. We applied these criteria retrospectively to 403 charts of HIV-infected children. Of those studied, 331/403 received HAART. Comparing HAART exposed and HAART naïve children, the difference in EPF score, but not MDC, approached significance (). Young age at HIV diagnosis or at HAART initiation was associated with (+) EPF (). Adherence to HAART trended toward an association with (+) EPF (). Exposure to nevirapine, abacavir, or didanosine increased risk of (+) EPF (OR = 3.55 (CI = 1.99–6.33), 4.76 (2.39–9.43), 4.93 (1.29–18.87)). Neither EPF nor MDC identified a significant difference between HAART exposed or naïve children regarding possible MT. However, as indicators of HAART exposure are associated with (+) EPF, it may be a candidate for prospective study of possible HAART related MT in resource-poor settings. |
| format | Article |
| id | doaj-art-e0e65a53789143f5be746d2332ea4013 |
| institution | Kabale University |
| issn | 2090-1240 2090-1259 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | AIDS Research and Treatment |
| spelling | doaj-art-e0e65a53789143f5be746d2332ea40132025-08-20T03:25:59ZengWileyAIDS Research and Treatment2090-12402090-12592013-01-01201310.1155/2013/249171249171Performance of Clinical Criteria for Screening of Possible Antiretroviral Related Mitochondrial Toxicity in HIV-Infected Children in AccraAllison Langs-Barlow0Lorna Renner1Karol Katz2Veronika Northrup3Elijah Paintsil4Department of Pediatrics, Yale School of Medicine, New Haven, CT 06520, USADepartment of Child Health, Korle Bu Teaching Hospital, University of Ghana Medical School, P.O. Box kb77, Accra, GhanaYale Center for Analytical Sciences, Yale School of Public Health, New Haven, CT 06520, USAYale Center for Analytical Sciences, Yale School of Public Health, New Haven, CT 06520, USADepartment of Pediatrics, Yale School of Medicine, New Haven, CT 06520, USAMitochondrial damage is implicated in highly active antiretroviral therapy (HAART) toxicity. HIV infection also causes mitochondrial toxicity (MT). Differentiating between the two is critical for HIV management. Our objective was to test the utility of the Mitochondrial Disease Criteria (MDC) and the Enquête Périnatale Française (EPF) to screen for possible HAART related MT in HIV-infected children in Ghana. The EPF and MDC are compilations of clinical symptoms, or criteria, of MT: a (+) score indicates possible MT. We applied these criteria retrospectively to 403 charts of HIV-infected children. Of those studied, 331/403 received HAART. Comparing HAART exposed and HAART naïve children, the difference in EPF score, but not MDC, approached significance (). Young age at HIV diagnosis or at HAART initiation was associated with (+) EPF (). Adherence to HAART trended toward an association with (+) EPF (). Exposure to nevirapine, abacavir, or didanosine increased risk of (+) EPF (OR = 3.55 (CI = 1.99–6.33), 4.76 (2.39–9.43), 4.93 (1.29–18.87)). Neither EPF nor MDC identified a significant difference between HAART exposed or naïve children regarding possible MT. However, as indicators of HAART exposure are associated with (+) EPF, it may be a candidate for prospective study of possible HAART related MT in resource-poor settings.http://dx.doi.org/10.1155/2013/249171 |
| spellingShingle | Allison Langs-Barlow Lorna Renner Karol Katz Veronika Northrup Elijah Paintsil Performance of Clinical Criteria for Screening of Possible Antiretroviral Related Mitochondrial Toxicity in HIV-Infected Children in Accra AIDS Research and Treatment |
| title | Performance of Clinical Criteria for Screening of Possible Antiretroviral Related Mitochondrial Toxicity in HIV-Infected Children in Accra |
| title_full | Performance of Clinical Criteria for Screening of Possible Antiretroviral Related Mitochondrial Toxicity in HIV-Infected Children in Accra |
| title_fullStr | Performance of Clinical Criteria for Screening of Possible Antiretroviral Related Mitochondrial Toxicity in HIV-Infected Children in Accra |
| title_full_unstemmed | Performance of Clinical Criteria for Screening of Possible Antiretroviral Related Mitochondrial Toxicity in HIV-Infected Children in Accra |
| title_short | Performance of Clinical Criteria for Screening of Possible Antiretroviral Related Mitochondrial Toxicity in HIV-Infected Children in Accra |
| title_sort | performance of clinical criteria for screening of possible antiretroviral related mitochondrial toxicity in hiv infected children in accra |
| url | http://dx.doi.org/10.1155/2013/249171 |
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