CRRT Is More Than Just Continuous Renal Replacement Therapy
The physiology of the kidney has long been understood, and its mechanisms are well described. The pathology of renal failure is also a deeply researched area. It seems logical, therefore, to create devices that can replace the lost normal function of the kidney. Using the physical processes that tak...
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MDPI AG
2024-11-01
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| Online Access: | https://www.mdpi.com/1424-8247/17/12/1571 |
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| author | Lóránd Erdélyi Domonkos Trásy |
| author_facet | Lóránd Erdélyi Domonkos Trásy |
| author_sort | Lóránd Erdélyi |
| collection | DOAJ |
| description | The physiology of the kidney has long been understood, and its mechanisms are well described. The pathology of renal failure is also a deeply researched area. It seems logical, therefore, to create devices that can replace the lost normal function of the kidney. Using the physical processes that take place in the kidney, such as diffusion or convection across a membrane, various renal replacement therapies (RRT) have been created. There are those that are used intermittently and those that are used for longer periods. What they have in common is that all RRTs have the same purpose; to replace the excretory function of the kidney that has been lost. CRRT is an extracorporeal renal replacement therapy that effectively replicates the excretory function of the kidneys in cases of acute renal failure. However, it has become increasingly evident that this rapidly advancing treatment modality offers benefits beyond merely substituting kidney function, with its applications continuing to expand significantly with non-renal and other indications. The use of these devices has raised new questions, many of which are still not clearly answered. When should this start? Who should receive it? How long should it last? What indication should it be for? What modality should it be with? How does it change the pharmacokinetics of the medicines? To answer these questions, it is first worth understanding the mechanisms behind the processes and the factors that influence them. This should not only focus on the procedures used in RRT therapies, but also consider the patient’s condition and the physicochemical properties of the drugs. In this review, we aim to provide a literature summary to highlight the factors that may influence the success of RRT therapies. |
| format | Article |
| id | doaj-art-e0e5f26d98354bc4a4bd28bb783dbc48 |
| institution | DOAJ |
| issn | 1424-8247 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
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| spelling | doaj-art-e0e5f26d98354bc4a4bd28bb783dbc482025-08-20T02:43:49ZengMDPI AGPharmaceuticals1424-82472024-11-011712157110.3390/ph17121571CRRT Is More Than Just Continuous Renal Replacement TherapyLóránd Erdélyi0Domonkos Trásy1Faculty of Helath and Sport Science, Széchenyi István University, 9026 Győr, HungaryCentre for Translational Medicine, Semmelweis University, 1085 Budapest, HungaryThe physiology of the kidney has long been understood, and its mechanisms are well described. The pathology of renal failure is also a deeply researched area. It seems logical, therefore, to create devices that can replace the lost normal function of the kidney. Using the physical processes that take place in the kidney, such as diffusion or convection across a membrane, various renal replacement therapies (RRT) have been created. There are those that are used intermittently and those that are used for longer periods. What they have in common is that all RRTs have the same purpose; to replace the excretory function of the kidney that has been lost. CRRT is an extracorporeal renal replacement therapy that effectively replicates the excretory function of the kidneys in cases of acute renal failure. However, it has become increasingly evident that this rapidly advancing treatment modality offers benefits beyond merely substituting kidney function, with its applications continuing to expand significantly with non-renal and other indications. The use of these devices has raised new questions, many of which are still not clearly answered. When should this start? Who should receive it? How long should it last? What indication should it be for? What modality should it be with? How does it change the pharmacokinetics of the medicines? To answer these questions, it is first worth understanding the mechanisms behind the processes and the factors that influence them. This should not only focus on the procedures used in RRT therapies, but also consider the patient’s condition and the physicochemical properties of the drugs. In this review, we aim to provide a literature summary to highlight the factors that may influence the success of RRT therapies.https://www.mdpi.com/1424-8247/17/12/1571continuous renal replacement therapyCRRTadsorptionpharmacokinetics |
| spellingShingle | Lóránd Erdélyi Domonkos Trásy CRRT Is More Than Just Continuous Renal Replacement Therapy Pharmaceuticals continuous renal replacement therapy CRRT adsorption pharmacokinetics |
| title | CRRT Is More Than Just Continuous Renal Replacement Therapy |
| title_full | CRRT Is More Than Just Continuous Renal Replacement Therapy |
| title_fullStr | CRRT Is More Than Just Continuous Renal Replacement Therapy |
| title_full_unstemmed | CRRT Is More Than Just Continuous Renal Replacement Therapy |
| title_short | CRRT Is More Than Just Continuous Renal Replacement Therapy |
| title_sort | crrt is more than just continuous renal replacement therapy |
| topic | continuous renal replacement therapy CRRT adsorption pharmacokinetics |
| url | https://www.mdpi.com/1424-8247/17/12/1571 |
| work_keys_str_mv | AT loranderdelyi crrtismorethanjustcontinuousrenalreplacementtherapy AT domonkostrasy crrtismorethanjustcontinuousrenalreplacementtherapy |