Chaperonin containing TCP1 subunit 5 as a novel pan-cancer prognostic biomarker for tumor stemness and immunotherapy response: insights from multi-omics data, integrated machine learning, and experimental validation

Chaperonin containing TCP1 subunit 5 as a novel pan-cancer prognostic biomarker for tumor stemness and immunotherapy response: insights from multi-omics data, integrated machine learning, and experimental validation

Abstract Background Chaperonin containing TCP1 subunit 5 (CCT5), a vital component of the molecular chaperonin complex, has been implicated in tumorigenesis, cancer stemness maintenance, and therapeutic resistance. Nevertheless, its comprehensive roles in pan-cancer progression, underlying biologica...

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Bibliographic Details
Main Authors: Jiajun Li, Nuo Xu, Leyin Hu, Jiayue Xu, Yifan Huang, Deqi Wang, Feng Chen, Yi Wang, Jiani Jiang, Yanggang Hong, Huajun Ye
Format: Article
Language:English
Published: Springer 2025-05-01
Series:Cancer Immunology, Immunotherapy
Subjects:
CCT5
Pan-cancer
Cancer stemness
Tumor microenvironment
Immune checkpoint blockade
Single-cell analysis
Online Access:https://doi.org/10.1007/s00262-025-04071-7
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