Analysis of antibody and cytokine markers for leprosy nerve damage and reactions in the INFIR cohort in India.
<h4>Background</h4>The ILEP Nerve Function Impairment in Reaction (INFIR) is a cohort study designed to identify predictors of reactions and nerve function impairment (NFI) in leprosy.<h4>Aim of the study</h4>Antibodies to mycobacteria, nerve components and serum cytokine wer...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2011-03-01
|
| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0000977&type=printable |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850128646987055104 |
|---|---|
| author | Rupendra Jadhav Lavanya Suneetha Ravindra Kamble Vidyagouri Shinde Karuna Devi Meher Vani Chaduvula Renuka Raju Sujai Suneetha Peter G Nicholls Wim H van Brakel Diana N J Lockwood |
| author_facet | Rupendra Jadhav Lavanya Suneetha Ravindra Kamble Vidyagouri Shinde Karuna Devi Meher Vani Chaduvula Renuka Raju Sujai Suneetha Peter G Nicholls Wim H van Brakel Diana N J Lockwood |
| author_sort | Rupendra Jadhav |
| collection | DOAJ |
| description | <h4>Background</h4>The ILEP Nerve Function Impairment in Reaction (INFIR) is a cohort study designed to identify predictors of reactions and nerve function impairment (NFI) in leprosy.<h4>Aim of the study</h4>Antibodies to mycobacteria, nerve components and serum cytokine were measured as potential markers for their possible association with reactions and NFI.<h4>Patients and methods</h4>303 newly diagnosed leprosy patients from two centres in North India were enrolled. Antibodies to PGL-1, LAM (IgG1 and IgG3), ceramide, S100 and TNFα levels were measured using ELISA techniques.<h4>Results</h4>S-100, PGL IgG and IgM antibody levels were lowest in patients with BT leprosy and highest in patients with lepromatous leprosy. LAM IgG1 and LAM IgG3 antibody levels were highest in patients with BL leprosy. Ceramide antibody levels were not correlated with type of leprosy. Levels of all the antibodies tested and TNF α were lowest in patients with only skin reaction. PGL IgM antibody levels were elevated in patients with skin reactions and NFI. Old sensory NFI is associated with significant elevation of PGL IgG, LAM IgG and S100 antibody levels.<h4>Conclusion</h4>These results reveal that the antibody response to mycobacterial antigens, nerve antigens and cytokines are in a dynamic flux and could collectively contribute to NFI in leprosy. The association of multiple markers with old NFI may indicate the contribution of different pathological processes. |
| format | Article |
| id | doaj-art-e0e5157db4f84d4a95be01d03e7b1542 |
| institution | OA Journals |
| issn | 1935-2727 1935-2735 |
| language | English |
| publishDate | 2011-03-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj-art-e0e5157db4f84d4a95be01d03e7b15422025-08-20T02:33:12ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352011-03-0153e97710.1371/journal.pntd.0000977Analysis of antibody and cytokine markers for leprosy nerve damage and reactions in the INFIR cohort in India.Rupendra JadhavLavanya SuneethaRavindra KambleVidyagouri ShindeKaruna DeviMeher Vani ChaduvulaRenuka RajuSujai SuneethaPeter G NichollsWim H van BrakelDiana N J Lockwood<h4>Background</h4>The ILEP Nerve Function Impairment in Reaction (INFIR) is a cohort study designed to identify predictors of reactions and nerve function impairment (NFI) in leprosy.<h4>Aim of the study</h4>Antibodies to mycobacteria, nerve components and serum cytokine were measured as potential markers for their possible association with reactions and NFI.<h4>Patients and methods</h4>303 newly diagnosed leprosy patients from two centres in North India were enrolled. Antibodies to PGL-1, LAM (IgG1 and IgG3), ceramide, S100 and TNFα levels were measured using ELISA techniques.<h4>Results</h4>S-100, PGL IgG and IgM antibody levels were lowest in patients with BT leprosy and highest in patients with lepromatous leprosy. LAM IgG1 and LAM IgG3 antibody levels were highest in patients with BL leprosy. Ceramide antibody levels were not correlated with type of leprosy. Levels of all the antibodies tested and TNF α were lowest in patients with only skin reaction. PGL IgM antibody levels were elevated in patients with skin reactions and NFI. Old sensory NFI is associated with significant elevation of PGL IgG, LAM IgG and S100 antibody levels.<h4>Conclusion</h4>These results reveal that the antibody response to mycobacterial antigens, nerve antigens and cytokines are in a dynamic flux and could collectively contribute to NFI in leprosy. The association of multiple markers with old NFI may indicate the contribution of different pathological processes.https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0000977&type=printable |
| spellingShingle | Rupendra Jadhav Lavanya Suneetha Ravindra Kamble Vidyagouri Shinde Karuna Devi Meher Vani Chaduvula Renuka Raju Sujai Suneetha Peter G Nicholls Wim H van Brakel Diana N J Lockwood Analysis of antibody and cytokine markers for leprosy nerve damage and reactions in the INFIR cohort in India. PLoS Neglected Tropical Diseases |
| title | Analysis of antibody and cytokine markers for leprosy nerve damage and reactions in the INFIR cohort in India. |
| title_full | Analysis of antibody and cytokine markers for leprosy nerve damage and reactions in the INFIR cohort in India. |
| title_fullStr | Analysis of antibody and cytokine markers for leprosy nerve damage and reactions in the INFIR cohort in India. |
| title_full_unstemmed | Analysis of antibody and cytokine markers for leprosy nerve damage and reactions in the INFIR cohort in India. |
| title_short | Analysis of antibody and cytokine markers for leprosy nerve damage and reactions in the INFIR cohort in India. |
| title_sort | analysis of antibody and cytokine markers for leprosy nerve damage and reactions in the infir cohort in india |
| url | https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0000977&type=printable |
| work_keys_str_mv | AT rupendrajadhav analysisofantibodyandcytokinemarkersforleprosynervedamageandreactionsintheinfircohortinindia AT lavanyasuneetha analysisofantibodyandcytokinemarkersforleprosynervedamageandreactionsintheinfircohortinindia AT ravindrakamble analysisofantibodyandcytokinemarkersforleprosynervedamageandreactionsintheinfircohortinindia AT vidyagourishinde analysisofantibodyandcytokinemarkersforleprosynervedamageandreactionsintheinfircohortinindia AT karunadevi analysisofantibodyandcytokinemarkersforleprosynervedamageandreactionsintheinfircohortinindia AT mehervanichaduvula analysisofantibodyandcytokinemarkersforleprosynervedamageandreactionsintheinfircohortinindia AT renukaraju analysisofantibodyandcytokinemarkersforleprosynervedamageandreactionsintheinfircohortinindia AT sujaisuneetha analysisofantibodyandcytokinemarkersforleprosynervedamageandreactionsintheinfircohortinindia AT petergnicholls analysisofantibodyandcytokinemarkersforleprosynervedamageandreactionsintheinfircohortinindia AT wimhvanbrakel analysisofantibodyandcytokinemarkersforleprosynervedamageandreactionsintheinfircohortinindia AT diananjlockwood analysisofantibodyandcytokinemarkersforleprosynervedamageandreactionsintheinfircohortinindia |