Influence of intravenous ferric carboxymaltose on non-invasive parameters of left ventricular myocardial work in patients with heart failure with reduced ejection fraction
Aim. To assess non-invasive parameters of left ventricular (LV) myocardial work in patients with heart failure with reduced ejection fraction (CHrEF) and iron deficiency (ID) after ferric carboxymaltose (FCM) therapy.Material and methods. There were following inclusion criteria: LV ejection fraction...
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«FIRMA «SILICEA» LLC
2023-02-01
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| Series: | Российский кардиологический журнал |
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| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/5310 |
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| author | Zh. D. Kobalava A. F. Safarova A. A. Lapshin |
| author_facet | Zh. D. Kobalava A. F. Safarova A. A. Lapshin |
| author_sort | Zh. D. Kobalava |
| collection | DOAJ |
| description | Aim. To assess non-invasive parameters of left ventricular (LV) myocardial work in patients with heart failure with reduced ejection fraction (CHrEF) and iron deficiency (ID) after ferric carboxymaltose (FCM) therapy.Material and methods. There were following inclusion criteria: LV ejection fraction (EF) ≤40%; body >70 kg, receiving best medical therapy (BMT) in recommended doses in accordance with the guidelines of the European Society of Cardiology and the Russian Society of Cardiology. Median age was 67±11,7 years (men, 83%), while median LVEF and N-terminal pro-brain natriuretic peptide was 29% and 315 ng/ml, respectively. Patients were randomized by the envelope method. The first group consisted of 19 patients who received therapy with intravenous FCM 1500 mg in 2 injections with an interval of one week between injections in addition to BMT. The control group consisted of 16 patients who received BMT without FCM. All patients underwent a standard echocardiography, and non-invasive LV myocardial work was assessed immediately before inclusion in the study and after 3 months.Results. In the first group of patients receiving FCM therapy, an increase in LVEF (29,1±10,3 vs 35,4±11,1; p=0,001), mitral annular plane systolic excursion (1,2 (1;1,6 ) vs 1,5 (1,3;1,9), p=0,001), LV global longitudinal strain (-7 (-5;-8) vs -8 (-6;-11), p=0,007) and non-invasive indicators of myocardial work (global work index (826±314 vs 1041±354), p=0,0001; global constructive work (1173±388 vs 1435±405), p=0,0001; global work efficiency (85 (82;87) vs 86 (82;88), p=0,017)). There were no significant changes in the studied parameters in the BMT group.Conclusion. Patients with HFrEF and ID treated with FCM showed a significant increase in LV systolic function, including non-invasive myocardial work parameters, compared with the control group. |
| format | Article |
| id | doaj-art-e0de3eba44444b36af3fd9050645675d |
| institution | DOAJ |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| publishDate | 2023-02-01 |
| publisher | «FIRMA «SILICEA» LLC |
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| series | Российский кардиологический журнал |
| spelling | doaj-art-e0de3eba44444b36af3fd9050645675d2025-08-20T03:21:32Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202023-02-0128110.15829/1560-4071-2023-53103743Influence of intravenous ferric carboxymaltose on non-invasive parameters of left ventricular myocardial work in patients with heart failure with reduced ejection fractionZh. D. Kobalava0A. F. Safarova1A. A. Lapshin2Peoples’ Friendship University of RussiaPeoples’ Friendship University of RussiaPeoples’ Friendship University of RussiaAim. To assess non-invasive parameters of left ventricular (LV) myocardial work in patients with heart failure with reduced ejection fraction (CHrEF) and iron deficiency (ID) after ferric carboxymaltose (FCM) therapy.Material and methods. There were following inclusion criteria: LV ejection fraction (EF) ≤40%; body >70 kg, receiving best medical therapy (BMT) in recommended doses in accordance with the guidelines of the European Society of Cardiology and the Russian Society of Cardiology. Median age was 67±11,7 years (men, 83%), while median LVEF and N-terminal pro-brain natriuretic peptide was 29% and 315 ng/ml, respectively. Patients were randomized by the envelope method. The first group consisted of 19 patients who received therapy with intravenous FCM 1500 mg in 2 injections with an interval of one week between injections in addition to BMT. The control group consisted of 16 patients who received BMT without FCM. All patients underwent a standard echocardiography, and non-invasive LV myocardial work was assessed immediately before inclusion in the study and after 3 months.Results. In the first group of patients receiving FCM therapy, an increase in LVEF (29,1±10,3 vs 35,4±11,1; p=0,001), mitral annular plane systolic excursion (1,2 (1;1,6 ) vs 1,5 (1,3;1,9), p=0,001), LV global longitudinal strain (-7 (-5;-8) vs -8 (-6;-11), p=0,007) and non-invasive indicators of myocardial work (global work index (826±314 vs 1041±354), p=0,0001; global constructive work (1173±388 vs 1435±405), p=0,0001; global work efficiency (85 (82;87) vs 86 (82;88), p=0,017)). There were no significant changes in the studied parameters in the BMT group.Conclusion. Patients with HFrEF and ID treated with FCM showed a significant increase in LV systolic function, including non-invasive myocardial work parameters, compared with the control group.https://russjcardiol.elpub.ru/jour/article/view/5310heart failure with reduced ejection fractioniron deficiencymyocardial work |
| spellingShingle | Zh. D. Kobalava A. F. Safarova A. A. Lapshin Influence of intravenous ferric carboxymaltose on non-invasive parameters of left ventricular myocardial work in patients with heart failure with reduced ejection fraction Российский кардиологический журнал heart failure with reduced ejection fraction iron deficiency myocardial work |
| title | Influence of intravenous ferric carboxymaltose on non-invasive parameters of left ventricular myocardial work in patients with heart failure with reduced ejection fraction |
| title_full | Influence of intravenous ferric carboxymaltose on non-invasive parameters of left ventricular myocardial work in patients with heart failure with reduced ejection fraction |
| title_fullStr | Influence of intravenous ferric carboxymaltose on non-invasive parameters of left ventricular myocardial work in patients with heart failure with reduced ejection fraction |
| title_full_unstemmed | Influence of intravenous ferric carboxymaltose on non-invasive parameters of left ventricular myocardial work in patients with heart failure with reduced ejection fraction |
| title_short | Influence of intravenous ferric carboxymaltose on non-invasive parameters of left ventricular myocardial work in patients with heart failure with reduced ejection fraction |
| title_sort | influence of intravenous ferric carboxymaltose on non invasive parameters of left ventricular myocardial work in patients with heart failure with reduced ejection fraction |
| topic | heart failure with reduced ejection fraction iron deficiency myocardial work |
| url | https://russjcardiol.elpub.ru/jour/article/view/5310 |
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