Cost‐Effectiveness of Radiofrequency Renal Denervation in Taiwan Based on Clinical Evidence and Regional Event Rates
ABSTRACT Radiofrequency renal denervation (RF RDN) is recognized as an adjunct therapy for hypertension. This study evaluated the cost‐effectiveness of RF RDN for the Taiwanese healthcare system using results from the SPYRAL HTN‐ON MED randomized, sham‐controlled trial. A decision‐analytic Markov mo...
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| Format: | Article |
| Language: | English |
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Wiley
2025-06-01
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| Series: | The Journal of Clinical Hypertension |
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| Online Access: | https://doi.org/10.1111/jch.70090 |
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| author | Hui‐Chun Huang Khoa N. Cao Anne M. Ryschon Kee‐Wong Phay Tzung‐Dau Wang Jan B. Pietzsch |
| author_facet | Hui‐Chun Huang Khoa N. Cao Anne M. Ryschon Kee‐Wong Phay Tzung‐Dau Wang Jan B. Pietzsch |
| author_sort | Hui‐Chun Huang |
| collection | DOAJ |
| description | ABSTRACT Radiofrequency renal denervation (RF RDN) is recognized as an adjunct therapy for hypertension. This study evaluated the cost‐effectiveness of RF RDN for the Taiwanese healthcare system using results from the SPYRAL HTN‐ON MED randomized, sham‐controlled trial. A decision‐analytic Markov model projected clinical events, costs, and quality‐adjusted life‐years (QALYs) for RF RDN versus standard‐of‐care (SoC) in an Asian population context. Clinical event risk reductions from treatment effects on office‐based systolic blood pressure (oSBP) were derived from a meta‐regression study of 47 hypertension trials. SPYRAL HTN‐ON MED demographics and results (oSBP reduction of 4.9 mmHg against sham) were used in the base case analysis. The incremental cost‐effectiveness ratio (ICER) was assessed against a willingness‐to‐pay (WTP) threshold of three million Taiwan dollars (TWD) per QALY gained. Compared to SoC, RF RDN was projected to reduce clinical events, with relative risks of 0.80, 0.88, and 0.74 for stroke, myocardial infarction (MI), and heart failure (HF), respectively. The incremental costs and QALYs were 216 381 TWD and 0.25, respectively, resulting in an ICER of 850 932 TWD per QALY gained. The ICER was cost‐effective across a broad range of uncertainty analyses. Model‐based projections adjusted for East Asian event rates suggest RF RDN may significantly reduce events, making it a cost‐effective intervention in the Taiwanese healthcare system for treating uncontrolled hypertension. |
| format | Article |
| id | doaj-art-e0dbc2b3b08d452482d87fa4c3785820 |
| institution | Kabale University |
| issn | 1524-6175 1751-7176 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Journal of Clinical Hypertension |
| spelling | doaj-art-e0dbc2b3b08d452482d87fa4c37858202025-08-20T03:56:10ZengWileyThe Journal of Clinical Hypertension1524-61751751-71762025-06-01276n/an/a10.1111/jch.70090Cost‐Effectiveness of Radiofrequency Renal Denervation in Taiwan Based on Clinical Evidence and Regional Event RatesHui‐Chun Huang0Khoa N. Cao1Anne M. Ryschon2Kee‐Wong Phay3Tzung‐Dau Wang4Jan B. Pietzsch5Cardiovascular Center and Division of Cardiology Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of Medicine Taipei City TaiwanWing Tech Inc. Menlo Park California USAWing Tech Inc. Menlo Park California USAMedtronic Taiwan Ltd. Taipei City TaiwanCardiovascular Center and Division of Cardiology Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of Medicine Taipei City TaiwanWing Tech Inc. Menlo Park California USAABSTRACT Radiofrequency renal denervation (RF RDN) is recognized as an adjunct therapy for hypertension. This study evaluated the cost‐effectiveness of RF RDN for the Taiwanese healthcare system using results from the SPYRAL HTN‐ON MED randomized, sham‐controlled trial. A decision‐analytic Markov model projected clinical events, costs, and quality‐adjusted life‐years (QALYs) for RF RDN versus standard‐of‐care (SoC) in an Asian population context. Clinical event risk reductions from treatment effects on office‐based systolic blood pressure (oSBP) were derived from a meta‐regression study of 47 hypertension trials. SPYRAL HTN‐ON MED demographics and results (oSBP reduction of 4.9 mmHg against sham) were used in the base case analysis. The incremental cost‐effectiveness ratio (ICER) was assessed against a willingness‐to‐pay (WTP) threshold of three million Taiwan dollars (TWD) per QALY gained. Compared to SoC, RF RDN was projected to reduce clinical events, with relative risks of 0.80, 0.88, and 0.74 for stroke, myocardial infarction (MI), and heart failure (HF), respectively. The incremental costs and QALYs were 216 381 TWD and 0.25, respectively, resulting in an ICER of 850 932 TWD per QALY gained. The ICER was cost‐effective across a broad range of uncertainty analyses. Model‐based projections adjusted for East Asian event rates suggest RF RDN may significantly reduce events, making it a cost‐effective intervention in the Taiwanese healthcare system for treating uncontrolled hypertension.https://doi.org/10.1111/jch.70090cost‐effectiveness analysishypertensionrenal denervationTaiwan |
| spellingShingle | Hui‐Chun Huang Khoa N. Cao Anne M. Ryschon Kee‐Wong Phay Tzung‐Dau Wang Jan B. Pietzsch Cost‐Effectiveness of Radiofrequency Renal Denervation in Taiwan Based on Clinical Evidence and Regional Event Rates The Journal of Clinical Hypertension cost‐effectiveness analysis hypertension renal denervation Taiwan |
| title | Cost‐Effectiveness of Radiofrequency Renal Denervation in Taiwan Based on Clinical Evidence and Regional Event Rates |
| title_full | Cost‐Effectiveness of Radiofrequency Renal Denervation in Taiwan Based on Clinical Evidence and Regional Event Rates |
| title_fullStr | Cost‐Effectiveness of Radiofrequency Renal Denervation in Taiwan Based on Clinical Evidence and Regional Event Rates |
| title_full_unstemmed | Cost‐Effectiveness of Radiofrequency Renal Denervation in Taiwan Based on Clinical Evidence and Regional Event Rates |
| title_short | Cost‐Effectiveness of Radiofrequency Renal Denervation in Taiwan Based on Clinical Evidence and Regional Event Rates |
| title_sort | cost effectiveness of radiofrequency renal denervation in taiwan based on clinical evidence and regional event rates |
| topic | cost‐effectiveness analysis hypertension renal denervation Taiwan |
| url | https://doi.org/10.1111/jch.70090 |
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