Associations of lower values of peak oxygen uptake and handgrip strength with a smaller liver volume
Background and aims: The associations between physical fitness markers and liver volume in the general population are unclear. We investigated the associations of peak oxygen uptake (VO2peak)and handgrip strength with liver volume in a general population sample. Methods and results: Data were taken...
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Upsala Medical Society
2025-05-01
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| Series: | Upsala Journal of Medical Sciences |
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| Online Access: | https://ujms.net/index.php/ujms/article/view/11924/19420 |
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| author | Muhammad Naeem Marcello Ricardo Paulista Markus Martin Bahls Mohammed Mousa Marcus Dörr Jens-Peter Kühn Robin Bülow Stephan B. Felix Giovanni Targher Beate Stubbe Ralf Ewert Henry Völzke Till Ittermann |
| author_facet | Muhammad Naeem Marcello Ricardo Paulista Markus Martin Bahls Mohammed Mousa Marcus Dörr Jens-Peter Kühn Robin Bülow Stephan B. Felix Giovanni Targher Beate Stubbe Ralf Ewert Henry Völzke Till Ittermann |
| author_sort | Muhammad Naeem |
| collection | DOAJ |
| description | Background and aims: The associations between physical fitness markers and liver volume in the general population are unclear. We investigated the associations of peak oxygen uptake (VO2peak)and handgrip strength with liver volume in a general population sample. Methods and results: Data were taken from 1,531 German adults (51.3% women), aged 20 to 88 years, from two cohorts of the population-based Study of Health in Pomerania (SHIP-START-2 and SHIP-TREND-0). We analysed cross-sectional associations of VO2peak and handgrip strength with liver volume derived from magnetic resonance imaging (MRI) by using multivariable linear regression models. These models were adjusted for age, sex, body fat mass, pre-existing type 2 diabetes, daily alcohol consumption, smoking status, and use of hypoglycaemic or antihypertensive medications. We observed significant associations of lower VO2peak and handgrip strength with a smaller liver volume in the whole population, as well as in both men and women. In the whole population, a 1 L/min lower VO2peak was associated with a 0.15 cm3 (95% confidence interval [CI]: 0.11 to 0.19; P < 0.0001) smaller liver volume for both sexes together. Similarly, a 1 kg lower handgrip strength was associated with a 7.05 cm3 (95% CI: 4.87 to 9.23; P < 0.001) smaller liver volume in the whole population. Conclusion: Our results derived from a large community-based sample showed that lower values of VO2peak and handgrip strength were associated with a smaller liver volume. These results might explain the possible negative effects of sedentary lifestyle on liver volume – the sedentary liver. |
| format | Article |
| id | doaj-art-e0d94b7b6718423b96ddacb157bc8fa8 |
| institution | OA Journals |
| issn | 0300-9734 2000-1967 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Upsala Medical Society |
| record_format | Article |
| series | Upsala Journal of Medical Sciences |
| spelling | doaj-art-e0d94b7b6718423b96ddacb157bc8fa82025-08-20T02:05:24ZengUpsala Medical SocietyUpsala Journal of Medical Sciences0300-97342000-19672025-05-011301710.48101/ujms.v130.1192411924Associations of lower values of peak oxygen uptake and handgrip strength with a smaller liver volumeMuhammad Naeem0Marcello Ricardo Paulista Markus1Martin Bahls2Mohammed Mousa3Marcus Dörr4Jens-Peter Kühn5Robin Bülow6Stephan B. Felix7Giovanni Targher8Beate Stubbe9Ralf Ewert10Henry Völzke11Till Ittermann12Institute for Community Medicine, SHIP/Department of Clinical Epidemiology, Greifswald, GermanyDepartment of Internal Medicine B – Cardiology, Intensive Care, Pulmonary Medicine and Infectious Diseases, Greifswald, GermanyDepartment of Internal Medicine B – Cardiology, Intensive Care, Pulmonary Medicine and Infectious Diseases, Greifswald, GermanyInstitute for Community Medicine, SHIP/Department of Clinical Epidemiology, Greifswald, GermanyDepartment of Internal Medicine B – Cardiology, Intensive Care, Pulmonary Medicine and Infectious Diseases, Greifswald, GermanyInstitute and Policlinic for Diagnostic and Interventional Neuroradiology, University Hospital, Carl Gustav Carus University, TU Dresden, Dresden, GermanyInstitute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, GermanyDepartment of Internal Medicine B – Cardiology, Intensive Care, Pulmonary Medicine and Infectious Diseases, Greifswald, GermanyDepartment of Medicine, University of Verona, Verona, ItalyDepartment of Internal Medicine B – Cardiology, Intensive Care, Pulmonary Medicine and Infectious Diseases, Greifswald, GermanyDepartment of Internal Medicine B – Cardiology, Intensive Care, Pulmonary Medicine and Infectious Diseases, Greifswald, GermanyInstitute for Community Medicine, SHIP/Department of Clinical Epidemiology, Greifswald, GermanyInstitute for Community Medicine, SHIP/Department of Clinical Epidemiology, Greifswald, GermanyBackground and aims: The associations between physical fitness markers and liver volume in the general population are unclear. We investigated the associations of peak oxygen uptake (VO2peak)and handgrip strength with liver volume in a general population sample. Methods and results: Data were taken from 1,531 German adults (51.3% women), aged 20 to 88 years, from two cohorts of the population-based Study of Health in Pomerania (SHIP-START-2 and SHIP-TREND-0). We analysed cross-sectional associations of VO2peak and handgrip strength with liver volume derived from magnetic resonance imaging (MRI) by using multivariable linear regression models. These models were adjusted for age, sex, body fat mass, pre-existing type 2 diabetes, daily alcohol consumption, smoking status, and use of hypoglycaemic or antihypertensive medications. We observed significant associations of lower VO2peak and handgrip strength with a smaller liver volume in the whole population, as well as in both men and women. In the whole population, a 1 L/min lower VO2peak was associated with a 0.15 cm3 (95% confidence interval [CI]: 0.11 to 0.19; P < 0.0001) smaller liver volume for both sexes together. Similarly, a 1 kg lower handgrip strength was associated with a 7.05 cm3 (95% CI: 4.87 to 9.23; P < 0.001) smaller liver volume in the whole population. Conclusion: Our results derived from a large community-based sample showed that lower values of VO2peak and handgrip strength were associated with a smaller liver volume. These results might explain the possible negative effects of sedentary lifestyle on liver volume – the sedentary liver.https://ujms.net/index.php/ujms/article/view/11924/19420peak oxygen uptakehandgrip strengthliver volume |
| spellingShingle | Muhammad Naeem Marcello Ricardo Paulista Markus Martin Bahls Mohammed Mousa Marcus Dörr Jens-Peter Kühn Robin Bülow Stephan B. Felix Giovanni Targher Beate Stubbe Ralf Ewert Henry Völzke Till Ittermann Associations of lower values of peak oxygen uptake and handgrip strength with a smaller liver volume Upsala Journal of Medical Sciences peak oxygen uptake handgrip strength liver volume |
| title | Associations of lower values of peak oxygen uptake and handgrip strength with a smaller liver volume |
| title_full | Associations of lower values of peak oxygen uptake and handgrip strength with a smaller liver volume |
| title_fullStr | Associations of lower values of peak oxygen uptake and handgrip strength with a smaller liver volume |
| title_full_unstemmed | Associations of lower values of peak oxygen uptake and handgrip strength with a smaller liver volume |
| title_short | Associations of lower values of peak oxygen uptake and handgrip strength with a smaller liver volume |
| title_sort | associations of lower values of peak oxygen uptake and handgrip strength with a smaller liver volume |
| topic | peak oxygen uptake handgrip strength liver volume |
| url | https://ujms.net/index.php/ujms/article/view/11924/19420 |
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