Type 1 interferon signature and allograft inflammatory factor-1 contribute to refractoriness to TNF inhibition in ankylosing spondylitis

Type 1 interferon signature and allograft inflammatory factor-1 contribute to refractoriness to TNF inhibition in ankylosing spondylitis

Abstract Ankylosing spondylitis (AS) is a chronic inflammatory arthritis that primarily affects the enthesis and may culminate in bony ankylosis of the spine. Despite TNF inhibitor (TNFi) being foundational in managing active inflammation, 30-40% of patients with AS remain non-responsive. Through lo...

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Main Authors: Woogil Song, Eunyoung Emily Lee, Seongwan Park, Baekgyu Choi, Min-Gang Kim, Seo Yoon Ban, Se Rim Choi, Jeong Yeon Kim, Seon Uk Kim, Jong-Il Kim, Eui-Cheol Shin, Inkyung Jung, Jeong Seok Lee, Eun Young Lee, the Single-Cell Atlas of Immune Diseases Consortium
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60445-6
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https://doi.org/10.1038/s41467-025-60445-6

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