Detectable 2019-nCoV viral RNA in blood is a strong indicator for the further clinical severity
The novel coronavirus (2019-nCoV) infection caused pneumonia. we retrospectively analyzed the virus presence in the pharyngeal swab, blood, and the anal swab detected by real-time PCR in the clinical lab. Unexpectedly, the 2109-nCoV RNA was readily detected in the blood (6 of 57 patients) and the an...
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-01-01
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| Series: | Emerging Microbes and Infections |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2020.1732837 |
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| author | Weilie Chen Yun Lan Xiaozhen Yuan Xilong Deng Yueping Li Xiaoli Cai Liya Li Ruiying He Yizhou Tan Xizi Deng Ming Gao Guofang Tang Lingzhai Zhao Jinlin Wang Qinghong Fan Chunyan Wen Yuwei Tong Yangbo Tang Fengyu Hu Feng Li Xiaoping Tang |
| author_facet | Weilie Chen Yun Lan Xiaozhen Yuan Xilong Deng Yueping Li Xiaoli Cai Liya Li Ruiying He Yizhou Tan Xizi Deng Ming Gao Guofang Tang Lingzhai Zhao Jinlin Wang Qinghong Fan Chunyan Wen Yuwei Tong Yangbo Tang Fengyu Hu Feng Li Xiaoping Tang |
| author_sort | Weilie Chen |
| collection | DOAJ |
| description | The novel coronavirus (2019-nCoV) infection caused pneumonia. we retrospectively analyzed the virus presence in the pharyngeal swab, blood, and the anal swab detected by real-time PCR in the clinical lab. Unexpectedly, the 2109-nCoV RNA was readily detected in the blood (6 of 57 patients) and the anal swabs (11 of 28 patients). Importantly, all of the 6 patients with detectable viral RNA in the blood cohort progressed to severe symptom stage, indicating a strong correlation of serum viral RNA with the disease severity (p-value = 0.0001). Meanwhile, 8 of the 11 patients with annal swab virus-positive was in severe clinical stage. However, the concentration of viral RNA in the anal swab (Ct value = 24 + 39) was higher than in the blood (Ct value = 34 + 39) from patient 2, suggesting that the virus might replicate in the digestive tract. Altogether, our results confirmed the presence of virus RNA in extra-pulmonary sites. |
| format | Article |
| id | doaj-art-e0d358a2dc51467cbd494835fa76487b |
| institution | OA Journals |
| issn | 2222-1751 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj-art-e0d358a2dc51467cbd494835fa76487b2025-08-20T02:12:20ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512020-01-019146947310.1080/22221751.2020.1732837Detectable 2019-nCoV viral RNA in blood is a strong indicator for the further clinical severityWeilie Chen0Yun Lan1Xiaozhen Yuan2Xilong Deng3Yueping Li4Xiaoli Cai5Liya Li6Ruiying He7Yizhou Tan8Xizi Deng9Ming Gao10Guofang Tang11Lingzhai Zhao12Jinlin Wang13Qinghong Fan14Chunyan Wen15Yuwei Tong16Yangbo Tang17Fengyu Hu18Feng Li19Xiaoping Tang20Guangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, People’s Republic of ChinaGuangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, People’s Republic of ChinaGuangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, People’s Republic of ChinaGuangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, People’s Republic of ChinaGuangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, People’s Republic of ChinaGuangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, People’s Republic of ChinaGuangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, People’s Republic of ChinaGuangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, People’s Republic of ChinaGuangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, People’s Republic of ChinaGuangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, People’s Republic of ChinaGuangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, People’s Republic of ChinaGuangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, People’s Republic of ChinaGuangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, People’s Republic of ChinaGuangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, People’s Republic of ChinaGuangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, People’s Republic of ChinaGuangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, People’s Republic of ChinaGuangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, People’s Republic of ChinaGuangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, People’s Republic of ChinaGuangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, People’s Republic of ChinaGuangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, People’s Republic of ChinaGuangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, People’s Republic of ChinaThe novel coronavirus (2019-nCoV) infection caused pneumonia. we retrospectively analyzed the virus presence in the pharyngeal swab, blood, and the anal swab detected by real-time PCR in the clinical lab. Unexpectedly, the 2109-nCoV RNA was readily detected in the blood (6 of 57 patients) and the anal swabs (11 of 28 patients). Importantly, all of the 6 patients with detectable viral RNA in the blood cohort progressed to severe symptom stage, indicating a strong correlation of serum viral RNA with the disease severity (p-value = 0.0001). Meanwhile, 8 of the 11 patients with annal swab virus-positive was in severe clinical stage. However, the concentration of viral RNA in the anal swab (Ct value = 24 + 39) was higher than in the blood (Ct value = 34 + 39) from patient 2, suggesting that the virus might replicate in the digestive tract. Altogether, our results confirmed the presence of virus RNA in extra-pulmonary sites.https://www.tandfonline.com/doi/10.1080/22221751.2020.17328372019-ncovlaboratory testblood viral RNApharyngeal swabanal swab |
| spellingShingle | Weilie Chen Yun Lan Xiaozhen Yuan Xilong Deng Yueping Li Xiaoli Cai Liya Li Ruiying He Yizhou Tan Xizi Deng Ming Gao Guofang Tang Lingzhai Zhao Jinlin Wang Qinghong Fan Chunyan Wen Yuwei Tong Yangbo Tang Fengyu Hu Feng Li Xiaoping Tang Detectable 2019-nCoV viral RNA in blood is a strong indicator for the further clinical severity Emerging Microbes and Infections 2019-ncov laboratory test blood viral RNA pharyngeal swab anal swab |
| title | Detectable 2019-nCoV viral RNA in blood is a strong indicator for the further clinical severity |
| title_full | Detectable 2019-nCoV viral RNA in blood is a strong indicator for the further clinical severity |
| title_fullStr | Detectable 2019-nCoV viral RNA in blood is a strong indicator for the further clinical severity |
| title_full_unstemmed | Detectable 2019-nCoV viral RNA in blood is a strong indicator for the further clinical severity |
| title_short | Detectable 2019-nCoV viral RNA in blood is a strong indicator for the further clinical severity |
| title_sort | detectable 2019 ncov viral rna in blood is a strong indicator for the further clinical severity |
| topic | 2019-ncov laboratory test blood viral RNA pharyngeal swab anal swab |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2020.1732837 |
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